Product Details
| Product Name:
Aminaftone |
CAS No.:
14748-94-8 |
| Purity:
99.39% |
Supply Ability:
10g |
| Release date:
2024/11/19 |
Product Introduction
Bioactivity
| Name | Aminaftone |
| Description | Aminaftone, a derivative of 4-aminobenzoic acid, inhibits endothelin-1 (ET-1) production and is used to study hypertension and systemic sclerosis. |
| In vitro | In cell cultures, Aminaftone inhibits the production of Endothelin-1 (ET-1) by interfering with the transcription of the pre-pro-endothelin-1 (PPET-1) gene. Concentrations of ET-1 and PPET-1 relative gene expression increase upon incubation with IL-1beta. Aminaftone, when incubated in a concentration-dependent manner, significantly reduces the production of ET-1. A strong direct correlation is observed between ET-1 concentrations and PPET-1 relative gene expression. It is noteworthy that Aminaftone does not influence the activity of endothelin-converting enzyme (ECE)[2]. |
| In vivo | After 5 weeks, rats are randomly assigned to the following experimental groups: Control; Monocrotaline; Aminaftone 30 mg/kg/day; Aminaftone 150 mg/kg/day. In animals treated with Aminaftone at both doses, mortality is significantly lower compared to those treated with Monocrotaline alone. Aminaftone, especially at the highest dose, reduces the plasma concentration of ET-1 and appears to decrease right heart hypertrophy and the wall thickness of the pulmonary arteries. At the end of the experiment, no rats die in the control and Aminaftone 150 groups, while mortality is 38% in the Monocrotaline group and 13% in the Aminaftone 30 group. Overall, rats treated with Aminaftone show a significantly lower mortality compared to rats in the Monocrotaline group (P=0.044)[1]. |
| Storage | store at low temperature,keep away from direct sunlight | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice. |
| Solubility Information | DMSO : 60 mg/mL (193.97 mM)
|
| Keywords | Aminaftone |
| Inhibitors Related | Macitentan | BMS 182874 | Bosentan | BMS 182874 hydrochloride | Sitaxsentan sodium | Edonentan | Sulfisoxazole | Ambrisentan | Sparsentan | Aprocitentan | Nebentan potassium | Clazosentan |
| Related Compound Libraries | Pain-Related Compound Library | Bioactive Compound Library | Membrane Protein-targeted Compound Library | Bioactive Compounds Library Max | GPCR Compound Library |
Company Profile Introduction
Target Molecule Corp. (TargetMol) is a global high-tech enterprise, headquartered in Boston, MA, specializing in chemical and biological research product and service to meet the research needs of global customers.
TargetMol has evolved into one of the biggest global compound library and small molecule suppliers and a customer based on 40+ countries. TargetMol offers over 80 types of compound libraries and a wide range of high-quality research chemicals including inhibitors, activator, natural compounds, peptides, inhibitory antibodies, and novel life-science kits, for laboratory and scientific use. Besides, virtual screening service is also available for customers who would like to conduct the computer-aided drug discovery.
You may like
-
CAS:2089314-64-5
$60.00 / 1mg
-
CAS:14154-42-8
$53.00 / 10mg
-
CAS:103475-41-8
$51.00 / 1mg
Recommended supplier
| Product name |
Price |
|
Suppliers |
Update time |
|
|
$350.00/1mg |
VIP3Y
|
TargetMol Chemicals Inc.
|
2024-11-19 |
United States