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Postion:Product Catalog >AMG 837 calcium hydrate
AMG 837 calcium hydrate
  • AMG 837 calcium hydrate

AMG 837 calcium hydrate NEW

Price $48 $73 $153
Package 5mg 10mg 25mg
Min. Order:
Supply Ability: 10g
Update Time: 2024-11-19

Product Details

Product Name: AMG 837 calcium hydrate CAS No.: 1259389-38-2
Purity: 98.07% Supply Ability: 10g
Release date: 2024/11/19

Product Introduction

Bioactivity

NameAMG 837 calcium hydrate
DescriptionAMG 837 calcium hydrate, a potent GPR40 agonist with an EC50 of 13 nM, exhibits high selectivity over GPR41, GPR43, and GPR120 (EC50 > 10,000 nM).
In vitroGPR40 agonist AMG 837 displayed the expected two-fold increase in potency on GPR4 (EC50: 13 nM) compared to the racemic compound and its activity crossed over to the rat and mouse forms of GPR40 (EC50s: 23/13 nM). AMG 837 was a partial agonist on GPR40 with maximal activity 85% of that shown by DHA. An external panel of 64 receptors also revealed no significant activity with the exception of weak inhibition (IC50: 3 μM) on the α2-adrenergic receptor [1].
In vivoIn rats, AMG 837 increases insulin release when glucose levels are elevated [2].
StoragePowder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice.
Solubility InformationDMSO : 40 mg/mL (87.83 mM)
Keywordsinsulin | Inhibitor | inhibit | GPR40 | glucose | Free Fatty Acid Receptor | FFAR | FFA1 | AMG 837 calcium Hydrate | AMG 837 calcium hydrate | AMG 837 calcium
Inhibitors RelatedVincamine | Monomethyl fumarate | Questiomycin A | Azathioprine | CRTh2 antagonist 2 | Fezagepras sodium | Benzyl nicotinate | 1-methoxycyclopropanecarboxylic acid | TUG-1375 | CAY10595 | Timapiprant | NF-56-EJ40
Related Compound LibrariesBioactive Compound Library | Membrane Protein-targeted Compound Library | Endocrinology-Hormone Compound Library | Orally Active Compound Library | Bioactive Compounds Library Max | Fluorochemical Library | GPCR Compound Library | Anti-Cancer Compound Library

Company Profile Introduction

Target Molecule Corp. (TargetMol) is a global high-tech enterprise, headquartered in Boston, MA, specializing in chemical and biological research product and service to meet the research needs of global customers. TargetMol has evolved into one of the biggest global compound library and small molecule suppliers and a customer based on 40+ countries. TargetMol offers over 80 types of compound libraries and a wide range of high-quality research chemicals including inhibitors, activator, natural compounds, peptides, inhibitory antibodies, and novel life-science kits, for laboratory and scientific use. Besides, virtual screening service is also available for customers who would like to conduct the computer-aided drug discovery.

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