AMG 510 NEW
Price | Get Latest Price | ||
Package | 1KG | 10KG | 25KG |
Min. Order: | 1KG |
Supply Ability: | 5000 |
Update Time: | 2024-12-06 |
Product Details
Product Name: AMG 510 | CAS No.: 2252403-56-6 |
Min. Order: 1KG | Purity: 99% |
Supply Ability: 5000 | Release date: 2024/12/06 |
AMG 510 CAS:2252403-56-6 Pharmaceutical Raw Materials
Product Name:AMG 510
Synonyms:6-FLUORO-7-(2-FLUORO-6-HYDROXYPHENYL)-1-[4-METHYL-2-(PROPAN-2-YL)PYRIDIN-3-YL]-4-[(2S)-2-METHYL-4-(P;6-fluoro-7-(2-fluoro-6-hydroxyphenyl)-1-[4-methyl-2-(propan-2-yl)pyridin-3-yl]-4-[(2S)-2-methyl-4-(prop-2-enoyl)piperazin-1-yl]-1H,2H-pyrido[2,3-d]pyrimidin-2-one;AMG-510;AMG 510;AMG510;AMG 510;4-((S)-4-acryloyl-2-methylpiperazin-1-yl)-6-fluoro-7-(2-fluoro-6-hydroxyphenyl)-1-(2-isopropyl-4-methylpyridin-3-yl)pyrido[2,3-d]pyrimidin-2(1H)-one;chiral AMG 510, single isomer;CPD2809;AMG-510,AMG510
CAS:2252403-56-6
MF:C30H30F2N6O3
MW:560.59
Boiling point:730.5±70.0 °C(Predicted)
density:1.36±0.1 g/cm3(Predicted)
storage temp.:Store at -20°C, stored under nitrogen
solubility:DMSO:75.0(Max Conc. mg/mL);133.78(Max Conc. mM)
Water:33.33(Max Conc. mg/mL);59.45(Max Conc. mM)
Ethanol:8.0(Max Conc. mg/mL);14.27(Max Conc. mM)
Storage:-20°C, stored under nitrogen
Uses:AMG-510 is a KRAS G12C inhibitor thus leading to the regression of KRAS G12C tumors as it interrupts protein signaling.
Description
AMG-510 is a first-in-class, orally bioavailable, and selective KRAS G12C covalent inhibitor. AMG-510 irreversibly inhibits KRAS G12C by locking it in an inactive GDP-bound state. AMG-510 is the first KRAS G12C inhibitor in clinical development and leads to the regression of KRAS G12C tumors.
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