ADU-S100 ammonium salt NEW
| Price | $159 | Get Latest Price |
| Package | 1mg | 5mg |
| Min. Order: | |
| Supply Ability: | 10g |
| Update Time: | 2024-11-18 |
Product Details
| Product Name: ADU-S100 ammonium salt | CAS No.: 1638750-96-5 |
| Purity: 98% | Supply Ability: 10g |
| Release date: 2024/11/18 |
Product Introduction
Bioactivity
| Name | ADU-S100 ammonium salt |
| Description | ADU-S100 ammonium salt is an activator of stimulator of interferon genes (STING). ADU-S100 ammonium salt leads to potent and systemic tumor regression and immunity. |
| In vitro | METHODS: BMDCs were treated with free ADU-S100 (0.5 μg/mL) or liposomal ADU-S100 (0.1 μg/mL) for 24 hours, and IFNβ (A) and TNFα (B) levels in the cell culture medium were measured using ELISA. RESULTS ADU-S100 enhanced the production of TNFα and IFNβ in BMDCs. [1] METHODS: Mouse cDC2 and human cDC2 were cultured in 12.5-200 μM ADU-S100 for 24 hours, and the effects of ADU-S100 on cDC2 were observed. RESULTS 25 μM ADU-S100 increased the expression of Tim-3 on DC, showing a significant upregulation of Tim-3. [3] |
| In vivo | METHODS: After a 50 μg bolus injection of ADU-S100 on day 14 after intracranial implantation of GL261 mice, brain infiltrating leukocytes (BILs) were analyzed in detail by flow cytometry using a panel of 13 immune markers. RESULTS Three days after treatment of ADU-S100, suppression of microglia, CD4+ and CD8+ T cell populations, and infiltration of NK and CD11b/Gr1 inflammatory immune cells were observed, and 7 days after treatment, the proportion of T cells recovered and increased compared to baseline levels. CD45-negative cells decreased shortly after treatment. [2] METHODS: B16F1-OVA cells/100 μL PBS were injected into the right groin of C57BL/6 mice, and tumor-bearing mice were treated intratumorally with saline and 50 μg ADU-S100 every 2 days during the first week. Then, the dose of S100 was reduced to 30 μg, while the frequency of administration remained unchanged. RESULTS Mice treated with ADU-S100 lost weight and had smaller tumors. [3] |
| Storage | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice. |
| Solubility Information | H2O : 5 mg/mL (6.90 mM), Sonication is recommended. DMSO : 12 mg/mL (16.58 mM), Sonication and heating are recommended. |
| Keywords | inhibit | ADU S100 ammonium salt | TMEM173 | STING | MIW815 | Inhibitor | MIW-815 | ML RR-S2 CDA ammonium | MIW815 ammonium | Stimulator of Interferon Genes | MITA | MPYS | ERIS | ADU-S100 | ML RR-S2 CDA | MIW 815 | ADU-S100 ammonium | ADUS100 ammonium salt |
| Inhibitors Related | SR-717 | ChX710 | SN-008 | Vadimezan | Dazostinag disodium | C-176 | Cridanimod | CCCP | diABZI STING agonist-1 trihydrochloride | MSA-2 | STING activator Compound 53 | C-178 |
Company Profile Introduction
Target Molecule Corp. (TargetMol) is a global high-tech enterprise, headquartered in Boston, MA, specializing in chemical and biological research product and service to meet the research needs of global customers.
TargetMol has evolved into one of the biggest global compound library and small molecule suppliers and a customer based on 40+ countries. TargetMol offers over 80 types of compound libraries and a wide range of high-quality research chemicals including inhibitors, activator, natural compounds, peptides, inhibitory antibodies, and novel life-science kits, for laboratory and scientific use. Besides, virtual screening service is also available for customers who would like to conduct the computer-aided drug discovery.
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United States- Since: 2011-01-07
- Address: 36?Washington?Street, Wellesley?Hills
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