AdipoRon NEW
Price | $30 | $48 | $109 |
Package | 5mg | 10mg | 25mg |
Min. Order: | |
Supply Ability: | 10g |
Update Time: | 2024-11-19 |
Product Details
Product Name: AdipoRon | CAS No.: 924416-43-3 |
Purity: 99.86% | Supply Ability: 10g |
Release date: 2024/11/19 |
Product Introduction
Bioactivity
Name | AdipoRon |
Description | AdipoRon (SC-396658) is an orally bioavailable adiponectin receptor agonist. It can combine with AdipoR1/2 (KD: 1.8/3.1 μM). |
Cell Research | The effects of AdipoRon on the proliferation of parenchymal and non-parenchymal hepatocytes are evaluated in vitro via L02 and RAW264.7, by MTT assay as described with slight modification: 100 μL cells suspension (6×104/mL) are seeded in a 96-well plate and incubated for 18 h. Fresh media with AdipoRon are added at specified concentrations, and the incubations continue for a further 24 h. Then cells are incubated for 4 h with 0.5 mg/mL of MTT, and analyzed in a microplate reader at 490 nm. Each group is performed in six replications. The mean absorbance values corrected for a blank (medium only) are calculated as percentages of survival. |
In vitro | In wild-type mice, AdipoRon administered orally (50 mg/kg) activates the AdipoR2–PPAR-α pathway in the liver or the AdipoR1–AMPK–PGC-1α pathway in skeletal muscle, thereby improving insulin resistance, lipid abnormalities, and glucose tolerance. In the skeletal muscle and liver of WT mice, AdipoRon (50 mg/kg, intravenously) significantly induces phosphorylation of AMPK via AdipoR1/2. Furthermore, AdipoRon ameliorates diabetic symptoms in the genetic obesity murine model db/db mice and extends the shortened lifespan of db/db mice on a high-fat diet. |
In vivo | AdipoRon, through its interaction with AdipoR1/2 in C2C12 myotubes, enhances the activation of AMPK and promotes the expression of PGC-1α as well as mitochondrial biogenesis. |
Storage | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice. |
Solubility Information | H2O : < 1 mg/mL (insoluble or slightly soluble) Ethanol : 47 mg/mL (109.7 mM) DMSO : 35 mg/mL (81.68 mM), Sonication is recommended. |
Keywords | AdipoRon | Adiponectin Receptor | AdipoRs | SC 396658 | Inhibitor | SC396658 | inhibit |
Inhibitors Related | Ticlopidine | Arctiin | Gramine |
Related Compound Libraries | Bioactive Compound Library | Membrane Protein-targeted Compound Library | Anti-Obesity Compound Library | NO PAINS Compound Library | Orally Active Compound Library | Bioactive Compounds Library Max | GPCR Compound Library | Anti-Metabolism Disease Compound Library | Human Metabolite Library |
Company Profile Introduction
Target Molecule Corp. (TargetMol) is a global high-tech enterprise, headquartered in Boston, MA, specializing in chemical and biological research product and service to meet the research needs of global customers.
TargetMol has evolved into one of the biggest global compound library and small molecule suppliers and a customer based on 40+ countries. TargetMol offers over 80 types of compound libraries and a wide range of high-quality research chemicals including inhibitors, activator, natural compounds, peptides, inhibitory antibodies, and novel life-science kits, for laboratory and scientific use. Besides, virtual screening service is also available for customers who would like to conduct the computer-aided drug discovery.
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