AC-73 NEW
| Price | $45 | $98 | $183 |
| Package | 1mg | 5mg | 10mg |
| Min. Order: | |
| Supply Ability: | 10g |
| Update Time: | 2024-11-16 |
Product Details
| Product Name: AC-73 | CAS No.: 775294-71-8 |
| Purity: 98.95% | Supply Ability: 10g |
| Release date: 2024/11/16 |
Product Introduction
Bioactivity
| 名稱 | AC-73 |
| 描述 | AC-73 is an orally available Cluster of Differentiation 147 (CD147) inhibitor with high bioavailability that selectively disrupts the dimerization of CD147 (the binding site is in the N-terminal IgC2 domain of CD147 including Glu64 and Glu73), resulting in inhibition of the CD147/ERK1/2/STAT3/MMP-2 pathway and inhibition of liver cancer cell motility and invasion. AC-73 has antiproliferative activity and induces autophagy in leukemia cells. |
| 體外活性 | AC-73 (5-10 μM; 24 hours; SMMC-7721 and Huh-7 cells) treatment results in a dose-dependent reduction in the migration and invasion of these HCC cell lines, with no significant effect on cell viability at 20 μM. AC-73 potentially binds to CD147 at Glu64 and Glu73 in the N-terminal IgC2 domain, which are located within the CD147 dimer interface. AC-73 (5-10 μM; 24 hours; SMMC-7721 cells), at 10 μM, significantly inhibits the mRNA expression of MMP-2 and MMP-9, especially MMP-2, without affecting MMP-1, MMP-3, MMP-7, MMP-11, or MMP-13, and reduces MMP-2 mRNA levels and protein secretion as confirmed by RT-qPCR and gelatin zymography. AC-73 (5-20 μM; 6 hours; SMMC-7721 cells) also dose-dependently attenuates ERK1/2 and STAT3 phosphorylation. |
| 體內(nèi)活性 | AC-73 (25-50 mg/kg; Injected; daily; for 3 weeks; Male BALB/c nu/nu mice with SMMC-7721 cells) treatment significantly decreases the incidence of metastatic foci in nude mice, inhibits the phosphorylation of ERK1/2 and STAT3 in a dose-dependent manner, and reduces MMP-2, but does not inhibit tumor cell proliferation in vivo.[1] |
| 存儲(chǔ)條件 | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice. |
| 溶解度 | DMSO : 100 mg/mL (313.09 mM) |
| 關(guān)鍵字 | AC 73 | AC73 | AC-73 |
| 相關(guān)產(chǎn)品 | Stavudine | Xylitol | Myricetin | Sodium 4-phenylbutyrate | Hydroxychloroquine | Guanidine hydrochloride | Taurine | Curcumin | Oxyresveratrol | Paeonol | Naringin | Gefitinib |
| 相關(guān)庫 | 經(jīng)典已知活性庫 | 自噬庫 | 抑制劑庫 | 已知活性化合物庫 |
Company Profile Introduction
Target Molecule Corp. (TargetMol) is a global high-tech enterprise, headquartered in Boston, MA, specializing in chemical and biological research product and service to meet the research needs of global customers.
TargetMol has evolved into one of the biggest global compound library and small molecule suppliers and a customer based on 40+ countries. TargetMol offers over 80 types of compound libraries and a wide range of high-quality research chemicals including inhibitors, activator, natural compounds, peptides, inhibitory antibodies, and novel life-science kits, for laboratory and scientific use. Besides, virtual screening service is also available for customers who would like to conduct the computer-aided drug discovery.
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United States- Since: 2011-01-07
- Address: 36?Washington?Street, Wellesley?Hills
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