Abietic Acid NEW
| Price | $45 | $68 | $98 |
| Package | 10mg | 25mg | 50mg |
| Min. Order: | |
| Supply Ability: | 10g |
| Update Time: | 2024-11-19 |
Product Details
| Product Name: Abietic Acid | CAS No.: 514-10-3 |
| Purity: 92.6% | Supply Ability: 10g |
| Release date: 2024/11/19 |
Product Introduction
Bioactivity
| Name | Abietic Acid |
| Description | Abietic Acid (Sylvic acid) is a diterpene extracted from Pimenta racemosavar. grissea with antimicrobial, antiproliferative and anti-obesity activities. It inhibits lipoxygenase activity and may be studied in allergic diseases. |
| In vitro | METHODS: Different concentrations of Abietic Acid (Sylvic acid) (20, 40, 80, 160 and 320 μmol/l) were added to the cell culture medium of RAW264.7 cells and then incubation was continued for 26 hours. In order for Abietic Acid (Sylvic acid) treatment to have an effect on inflammatory mediator secretion, different concentrations of Abietic Acid (Sylvic acid) (20, 40 and 80 μmol/l) were added to the cell culture medium of RAW264.7 cells and incubated for 2 h. Then 1 μg/ml LPS was added to the cell culture medium of RAW264.7 cells and incubation was continued for 24 h. The cell culture medium of RAW264.7 cells was then incubated for 2 h. The cell culture medium of RAW264.7 cells was then incubated for 24 h. RESULTS Low concentrations (20, 40 and 80 μmol/l) of Abietic Acid (Sylvic acid) did not affect the viability of RAW264.7 cells, while high concentrations (160 and 320 μmol/l) of Abietic Acid (Sylvic acid) decreased the viability of RAW264.7 cells. Low concentrations of Abietic Acid (Sylvic acid) significantly reduced the concentrations of IL-1β, TNF-α, IL-6 and MIP-2 induced by LPS in the cell culture medium of RAW264.7 cells. [2] |
| In vivo | METHODS: Swiss mice (Mus musculus) were treated orally in 50, 100, and 200 mg/kg of Abietic Acid (Sylvic acid) central nervous system (CNS) effects were assessed using open-field and rotational assays, and anti-oedema activity was investigated by measuring carrageenan, dextran, histamine, arachidonic acid, and prostaglandin-induced paw edema. RESULTS Oral administration of Abietic Acid (Sylvic acid) (200 mg/kg) showed no evidence of CNS effects, and the compound also exhibited significant anti-edema and anti-inflammatory activity in carrageenan and dextrose models. [1] |
| Storage | store at low temperature | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice. |
| Solubility Information | DMSO : 60 mg/mL (198.37 mM) |
| Keywords | inhibit | Abietic Acid | Inhibitor | Bacterial |
| Inhibitors Related | Neomycin sulfate | Dehydroacetic acid sodium | Ampicillin sodium | Methyl anthranilate | Kanamycin sulfate | Sulfamethoxazole sodium | Daidzein | Doxycycline | Dimethyl sulfoxide |
| Related Compound Libraries | Anti-Tumor Natural Product Library | Terpene Natural Product Library | Bioactive Compound Library | Selected Plant-Sourced Compound Library | Natural Product Library | Anti-Inflammatory Traditional Chinese Medicine Compound Library | Natural Product Library for HTS | Anti-infective Natural Product Library | Bioactive Compounds Library Max | Ancient Chinese Classical Formulas Compound Library |
Company Profile Introduction
Target Molecule Corp. (TargetMol) is a global high-tech enterprise, headquartered in Boston, MA, specializing in chemical and biological research product and service to meet the research needs of global customers.
TargetMol has evolved into one of the biggest global compound library and small molecule suppliers and a customer based on 40+ countries. TargetMol offers over 80 types of compound libraries and a wide range of high-quality research chemicals including inhibitors, activator, natural compounds, peptides, inhibitory antibodies, and novel life-science kits, for laboratory and scientific use. Besides, virtual screening service is also available for customers who would like to conduct the computer-aided drug discovery.
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