Ribociclib
Price | $228 |
Package | 200mg |
Min. Order: | 1g |
Supply Ability: | 100g |
Update Time: | 2020-05-17 |
Product Details
Product Name: Ribociclib | CAS No.: 1211441-98-3 |
Min. Order: 1g | Purity: ≥95% |
Supply Ability: 100g | Release date: 2020/05/17 |
Ribociclib, also known as LEE011, is an orally available cyclin-dependent kinase (CDK) inhibitor targeting cyclin D1/CDK4 and cyclin D3/CDK6 cell cycle pathway, with potential antineoplastic activity. CDK4/6 inhibitor LEE011 specifically inhibits CDK4 and 6, thereby inhibiting retinoblastoma (Rb) protein phosphorylation. Inhibition of Rb phosphorylation prevents CDK-mediated G1-S phase transition, thereby arresting the cell cycle in the G1 phase, suppressing DNA synthesis and inhibiting cancer cell growth. Overexpression of CDK4/6, as seen in certain types of cancer, causes cell cycle deregulation.
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- Since: 2005-05-19
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