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Postion:Product Catalog >Biochemical Engineering>Inhibitors>Apoptosis>PERK activator>SALUBRINAL
SALUBRINAL
  • SALUBRINAL
  • SALUBRINAL
  • SALUBRINAL

SALUBRINAL

Price $1
Package 1KG
Min. Order: 1KG
Supply Ability: 100kgs
Update Time: 2019-12-20

Product Details

Product Name: SALUBRINAL CAS No.: 405060-95-9
Min. Order: 1KG Purity: 99%
Supply Ability: 100kgs Release date: 2019/12/20

 

Mary 0010

Product Name:
SALUBRINAL
Synonyms:
(2E)-3-Phenyl-N-[2,2,2-trichloro-1-[[(8-quinolinylamino)thioxomethyl]amino]ethyl]-2-propenamide;2-Propenamide, 3-phenyl-N-[2,2,2-trichloro-1-[[(8-quinolinylamino)thioxomethyl]amino]ethyl]-, (2E)-;(2E)-3-Phenyl-N-[2,2,2-trichloro-1-[[(8-quinolinylamino)thioxomethyl]amino]ethyl]-2-propenamide Salubrinal;Salubrinal (2E)-3-Phenyl-N-[2,2,2-trichloro-1-[[(8-quinolinylamino)thioxomethyl]amino]ethyl]-2-propenamide;(E)-3-phenyl-N-[2,2,2-trichloro-1-(quinolin-8-ylcarbamothioylamino)ethyl]prop-2-enamide;N-(2,2,2-Trichloro-1-(3-(quinolin-8-yl)thioureido)ethyl)cinnAmamide;3-PHENYL-N-[2,2,2-TRICHLORO-1-[[(8-QUINOLINYLAMINO)THIOXOMETHYL]AMINO]ETHYL]-2-PROPENAMIDE;(E)-1-(quinolin-8-yl)-3-(2,2,2-trichloro-1-cinnamamidoethyl)thiourea
CAS:
405060-95-9
MF:
C21H17Cl3N4OS
MW:
479.81
EINECS:
 
Product Categories:
Inhibitors;Apoptosis Inhibitors;-
Mol File:
405060-95-9.mol
Article illustration
 
SALUBRINAL Chemical Properties
density 
1.474±0.06 g/cm3(Predicted)
storage temp. 
Store at +4°C
solubility 
DMSO: soluble20mg/mL, clear
form 
powder
pka
10.70±0.70(Predicted)
color 
, white to light yellow to light gray
Water Solubility 
Insoluble in water.
Sensitive 
Light Sensitive
 
Safety Information
Hazard Codes 
Xi
Risk Statements 
36/37/38
Safety Statements 
26
WGK Germany 
3
MSDS Information
 
 
SALUBRINAL Usage And Synthesis
Description
Selective eukaryotic translation initiation factor 2 subunit α (elF2α) dephosphorylation inhibitor. Salubrinal is a selective Inhibitor of eIF2α (eukaryotic translation initiation factor 2 α-subunit) dephosphorylation, and is primarily used experimentally, to study stress responses in eukaryotic cells associated with the action of eIF2. Salubrinal indirectly inhibits eIF2 as a result of reduced dephosphorylation of its α-subunit resulting in activation of stress response pathways usually triggered by events such as oxidative stress or buildup of unfolded protein in the endoplasmic reticulum. Salubrinal can protect PC12 cells from endoplasmic reticulum stress-mediated apoptosis (EC50 = 15 μM) and prevent replication of herpes virus (IC50 = 3 μM), by inhibiting dephosphorylation of eIF2α. As eIF2α has a role in bone formation, salubrinal is also being studied for its effects in osteoporosis. Besides, it also shows potential neuroprotective actions. Although salubrinal has putative therapeutic value due to its function, it is as yet only used experimentally.
References
1. https://en.wikipedia.org/wiki/Salubrinal
2. http://www.sigmaaldrich.com/catalog/product/sigma/sml0951?lang=en&region=CA
3. https://www.tocris.com/dispprod.php?ItemId=143907#.WQfadeyECP0
4. http://www.selleckchem.com/products/salubrinal.html
5. https://www.caymanchem.com/product/14735
6. https://www.hellobio.com/salubrinal.html
Uses
Salubrinal is an endoplasmic reticulum stress blocker that modulates sleep homeostasis and activation of sleep- and wake-regulatory neurons
Definition
ChEBI: A member of the class of quinolines that is a mixed aminal resulting from the formal condensation oftrichloroacetaldehyde with the amide nitrogen of trans-cinnamamide and the primary amino group of 1-quinolin-8-ylthiourea. It is a selective in ibitor of cellular complexes that dephosphorylate eukaryotic translation initiation factor 2 subunit alpha (eIF2alpha).
Biological Activity
Cell-permeable, selective inhibitor of cellular phosphatase complexes that dephosphorylate eukaryotic translation initiation factor 2 subunit α (eIF2 α ). Protects cells from endoplasmic reticulum stress-induced apoptosis (EC 50 ~ 15 μ M).
 
SALUBRINAL Preparation Products And Raw materials

Company Profile Introduction

Established in 2014,Career Henan Chemical Co. is a manufacturerspecializing in the sale of fine chemicals. Mainly deals in the sales of: Pharmaceutical intermediates OLED intermediates: Pharmaceutical intermediates; OLED intermediates;

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