7α-Hydroxy-4-cholesten-3-one NEW
| Price | $289 | $698 | $968 |
| Package | 1mg | 5mg | 10mg |
| Min. Order: | |
| Supply Ability: | 10g |
| Update Time: | 2024-11-07 |
Product Details
| Product Name: 7α-Hydroxy-4-cholesten-3-one | CAS No.: 3862-25-7 |
| Purity: 99.14% | Supply Ability: 10g |
| Release date: 2024/11/07 |
Product Introduction
Bioactivity
| 名稱 | 7α-Hydroxy-4-cholesten-3-one |
| 描述 | 7α-Hydroxy-4-cholesten-3-one is an intermediate in bile acid synthesis from cholesterol, a PXR agonist, and a biomarker for bile acid loss and diseases related to defective bile acid biosynthesis. It is also the physiological substrate for [CYP8B1]. |
| 體外活性 | 7α-Hydroxy-4-cholesten-3-one is a key intermediate in the bile acid synthesis pathway. Cytochrome P450 7A1 introduces a 7α-hydroxy group to cholesterol, and 3β-hydroxysteroid dehydrogenase then oxidizes and isomerizes the 3-hydroxy group and the Δ5,6-double bond, forming 7α-Hydroxy-4-cholesten-3-one. The absence of P450 27A1 downstream increases its concentration [1]. |
| 體內(nèi)活性 | 7α-Hydroxy-4-cholesten-3-one significantly influences the hepatic enzyme CYP7A1 activity under steady-state conditions and during rapid diurnal fluctuations in rats. Moreover, its serum levels exhibit a marked diurnal rhythm. |
| 存儲(chǔ)條件 | store at low temperature | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice. |
| 溶解度 | DMSO : 80 mg/mL (199.68 mM), Sonication is recommended. |
| 關(guān)鍵字 | 7αHydroxy4cholesten3one | 7α Hydroxy 4 cholesten 3 one | 7alpha-Hydroxy-4-cholesten-3-one | 7a-Hydroxy-4-cholesten-3-one | 7α-Hydroxy-4-cholesten-3-one |
Company Profile Introduction
TargetMol Chemicals Inc. is headquartered in Boston, MA, and specializes in products and services that serve the research needs of chemical and biological scientists worldwide. With a client base in 40+ countries, TargetMol has evolved into one of the biggest global research suppliers for compound libraries and small molecule compounds.
170+ Compound Libraries， 10000+ Noval Small Molecucles，16000+ Nature Compounds
TargetMol diligently updates and offers over 170 types of compound libraries and a wide range of high-quality research chemicals, including inhibitors, activators, natural products, peptides, antibodies , and novel life-science kits for laboratory and scientific use. In addition, our lab allows us to conduct CADD (computer-aided drug design) and chemical synthesis to meet the customization needs of our clients.
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United States- Since: 2011-01-07
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