Product Details
Product Name:
6RK73 |
CAS No.:
1895050-66-4 |
Purity:
100% |
Supply Ability:
10g |
Release date:
2024/11/19 |
Product Introduction
Bioactivity
Name | 6RK73 |
Description | 6RK73 is a covalent, irreversible, and specific UCHL1 inhibitor (IC50: 0.23 μM) with almost no inhibition of UCHL3 (IC50: 236 μM). |
Cell Research | Cell Line: MDA-MB-436 cells
Concentration: 5 μM
Incubation Time: 24, 48 hours |
In vitro | 6RK73 (5 μM; 1-3 hours) treatment displays strong inhibition of the TGFβ-induced pSMAD2 and pSMAD3, and a decrease of TβRI and total SMAD protein levels in MDA-MB-436 cells. 6RK73 (5 μM; 24-48 hours) results in migration significantly slower than the DMSO control group in MDA-MB-436 cells[1]. |
In vivo | 6RK73 displays a potent inhibition of breast cancer extravasation in zebrafish[1]. |
Storage | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice. |
Solubility Information | DMSO : 112.5 mg/mL (366 mM), Sonication is recommended.
|
Keywords | 6RK-73 | 6RK73 |
Related Compound Libraries | Bioactive Compound Library | Anti-Breast Cancer Compound Library | Inhibitor Library | Bioactive Compounds Library Max | Anti-Cancer Compound Library | Anti-Cancer Active Compound Library |
Company Profile Introduction
Target Molecule Corp. (TargetMol) is a global high-tech enterprise, headquartered in Boston, MA, specializing in chemical and biological research product and service to meet the research needs of global customers.
TargetMol has evolved into one of the biggest global compound library and small molecule suppliers and a customer based on 40+ countries. TargetMol offers over 80 types of compound libraries and a wide range of high-quality research chemicals including inhibitors, activator, natural compounds, peptides, inhibitory antibodies, and novel life-science kits, for laboratory and scientific use. Besides, virtual screening service is also available for customers who would like to conduct the computer-aided drug discovery.
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Recommended supplier
Product name |
Price |
|
Suppliers |
Update time |
|
$147.00/1mg |
VIP1Y
|
TargetMol Chemicals Inc.
|
2024-11-19 |