Bicalutamide
Price | Get Latest Price |
Package | 1Kg/Bag |
Min. Order: | 5g |
Supply Ability: | 800 kg |
Update Time: | 2019-09-23 |
Product Details
Product Name: Bicalutamide | CAS No.: 90357-06-5 |
Min. Order: 5g | Purity: 99% |
Supply Ability: 800 kg | Release date: 2019/09/23 |
Bicalutamide
(+-)--2-hydroxy-2-methyl;propanamide,n-(4-cyano-3-(trifluoromethyl)phenyl)-3-((4-fluorophenyl)sulfonyl);ICI-176334;CASODEX;BICALUTAMIDE;N-[(4-CYANO-3-TRIFLUOROMETHYL)PHENYL]-3-[(4-FLUOROPHENYL)SULFONYL]-2-HYDROXY-2-METHYLPROPANAMIDE;N-[4-CYANO-3-(TRIFLUOROMETHYL)PHENYL]-3-[(4-FLUOROPHENYL)SULFONYL]-2-HYDROXY-2-METHYLPROPIONANILIDE;Bicalutamide
90357-06-5
C18H14F4N2O4S
430.37
191-193°C
White Powder
USP
Pharma grade
Objective To evaluate the efficacy of bicalutamid (casodex) in the treatment of hormone-refractory prostate cancer
10g
Description
Bicalutamide is a member of the nonsteroidal antiandrogen (NSAA) group of medications. It works by blocking the androgen receptor (AR), the biological target of the androgen sex hormones testosterone and dihydrotestosterone (DHT). It does not lower androgen levels.[6] The medication can have some estrogen-like effects in men. Bicalutamide is well-absorbed, and its absorption is not affected by food. The terminal half-life of the medication is around one week. It is believed to cross the blood-brain barrier and affect both the body and brain.
Bicalutamid has a molecular weight of 430.37. The pKa' is approximately 12. Bicalutamid is a fine white to off white powder which is practically insoluble in water at 37°C (5 mg per 1000 mL), slightly soluble in chloroform and absolute ethanol, sparingly soluble in methanol, and soluble in acetone and tetrahydrofuran.CASODEX (bicalutamid) is a racemate with its antiandrogenic activity being almost exclusively exhibited by the R-enantiomer of bicalutamid; the S-enantiomer is essentially inactive.
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