GSK2982772
Price | $1 |
Package | 1KG |
Min. Order: | 1KG |
Supply Ability: | 1lg; 2kg; 5kg; 10kg; 100kg |
Update Time: | 2019-09-02 |
Product Details
Product Name: GSK2982772 | CAS No.: 1622848-92-3 |
Min. Order: 1KG | Purity: 98% |
Supply Ability: 1lg; 2kg; 5kg; 10kg; 100kg | Release date: 2019/09/02 |
Product number: Crystal-Liu |
▼
▲
Product Name:
GSK2982772
Synonyms:
1622848-92-3;(S)-5-benzyl-N-(5-methyl-4-oxo-2,3,4,5-tetrahydrobenzo[b][1,4]oxazepin-3-yl)-4H-1,2,4-triazole-3-carboxamide;GSK2982772
CAS:
1622848-92-3
MF:
C20H19N5O3
MW:
377.39656
EINECS:
Product Categories:
Mol File:
1622848-92-3.mol
▼
▲
GSK2982772 Chemical Properties
▼
▲
▼
▲
Safety Information
▼
▲
▼
▲
MSDS Information
▼
▲
GSK2982772 Usage And Synthesis
▼
▲
Description
(S)-5-benzyl-N-(5-methyl-4-oxo-2,3,4,5-tetrahydrobenzo[b][1,4]oxazepin-3-yl)-4H-1,2,4-triazole-3-carboxamide, also known as GSK2982772, is a first-in-class receptor interacting protein 1(RIP1)-kinase specific clinical candidate for the treatment of inflammatory disease. It is an inhibitor of RIP1 that regulates necroptosis and inflammation and may play an important role in contributing to a variety of human pathologies, including immune-mediated inflammatory diseases. It has excellent activity in blocking many TNF-dependent cellular responses. Highlighting its potential as a novel anti-inflammatory agent, the inhibitor was also able to reduce spontaneous production of cytokines from human ulcerative colitis explants.
References
Harris, P. A., et al. "Discovery of a First-in-Class Receptor Interacting Protein 1 (RIP1) Kinase Specific Clinical Candidate (GSK2982772) for the Treatment of Inflammatory Diseases." Journal of Medicinal Chemistry 60.4(2017):1247-1261.
Jeong, Jae Uk, et al. "Synthesis of ( S )-3-amino-benzo[ b ][1,4]oxazepin-4-one via Mitsunobu and S N Ar reaction for a first-in-class RIP1 kinase inhibitor GSK2982772 in clinical trials." Tetrahedron Letters 58.23(2017):2306-2308.
Jeong, Jae Uk, et al. "Synthesis of ( S )-3-amino-benzo[ b ][1,4]oxazepin-4-one via Mitsunobu and S N Ar reaction for a first-in-class RIP1 kinase inhibitor GSK2982772 in clinical trials." Tetrahedron Letters 58.23(2017):2306-2308.
Company Profile Introduction
Established in 2014,Career Henan Chemical Co. is a manufacturerspecializing in the sale of fine chemicals.
Mainly deals in the sales of:
Pharmaceutical intermediates
OLED intermediates:
Pharmaceutical intermediates;
OLED intermediates;
You may like
Recommended supplier
Product name | Price | Suppliers | Update time | |
---|---|---|---|---|
$68.00/1mg |
VIP5Y
|
TargetMol Chemicals Inc.
|
2024-11-19 |
- Since: 2014-12-17
- Address: No.967,15th Floor,Unit 7, Building 1, No.70 of DianChang Road, High-tech Development Zone, Zhengzho
INQUIRY
楊俊青
sales@coreychem.com
sales@coreychem.com