1,2,4-Benzenetricarboxylic anhydride  552-30-7 in stock factory  

Trimellitic anhydride

Trimellitic Anhydride is a low-molecular-weight chemical known to cause occupational asthma. It induces airway obstruction and eosinophilia after a latency period of sensitization.
Basic Info
Chemical Name     trimellitic anhydride
Synonyms     

1,2,4-Benzenetricarboxylic anhydride; Anhydrosepedonin; 1,3-dihydro-1,3-dioxo-5-isobenzofurancarboxylic acid; 1,3-dioxo-1,3-dihydro-isobenzofuran-5-carboxylic acid; 5-Isobenzofurancarboxylic acid, 1,3-dihydro-1,3-dioxo-; Expand
CAS No.     552-30-7
Molecular Formula     C9H4O5
Molecular Weight     192.12500
PSA     80.67000
LogP     0.69540
Properties
Appearance & Physical State     white to off-white flakes
Density     1.54
Boiling Point     390ºC
Melting Point     164-169ºC
Flash Point     227ºC
Refractive Index     1.662
Water Solubility     DECOMPOSES
Stability     Stable. Moisture sensitive.
Storage Condition     Store in a cool, dry place. Store in a tightly closed container.
Vapor Density     6.6 (vs air)
Vapor Pressure     <0.01 mm Hg ( 20 °C)
Safety Info
RTECS     DC2050000
Safety Statements     S22-S26-S36/37/39
HS Code     29173980
WGK Germany     1
Risk Statements     R37; R41; R42/43
Hazard Codes     Xn
Symbol     GHS05, GHS07, GHS08
Hazard Declaration     H317; H318; H334; H335
Signal Word     Danger
Caution Statement     P261; P280; P305 + P351 + P338; P342 + P311
Synthesis Route
Total 10 Documents >>

Section 1 - Chemical Product   MSDS Name:1 2 4-Benzenetricarboxylic anhydride 97% Material Safety Data Sheet
Synonym:Trimellitic anhydride; Androtrimellitic Acid; 1,3-Dihydro-1,3-dioxo-5-isobenzofurancarboxylic acid; TMA; TMA

Section 2 - COMPOSITION, INFORMATION ON INGREDIENTS

Hazard Symbols: XN XI
Risk Phrases: 36/37/38 42

Hazard identification
2.1 Classification of the substance or mixture

Serious eye damage, Category 1

Skin sensitization, Category 1

Specific target organ toxicity – single exposure, Category 3

Respiratory sensitization, Category 1
2.2 GHS label elements, including precautionary statements
Pictogram(s)     
Signal word     

Danger
Hazard statement(s)     

H318 Causes serious eye damage

H317 May cause an allergic skin reaction

H335 May cause respiratory irritation

H334 May cause allergy or asthma symptoms or breathing difficulties if inhaled
Precautionary statement(s)     
Prevention     

P280 Wear protective gloves/protective clothing/eye protection/face protection.

P261 Avoid breathing dust/fume/gas/mist/vapours/spray.

P272 Contaminated work clothing should not be allowed out of the workplace.

P271 Use only outdoors or in a well-ventilated area.

P284 [In case of inadequate ventilation] wear respiratory protection.
Response     

P305+P351+P338 IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continue rinsing.

P310 Immediately call a POISON CENTER/doctor/…

P302+P352 IF ON SKIN: Wash with plenty of water/...

P333+P313 If skin irritation or rash occurs: Get medical advice/attention.

P321 Specific treatment (see ... on this label).

P362+P364 Take off contaminated clothing and wash it before reuse.

P304+P340 IF INHALED: Remove person to fresh air and keep comfortable for breathing.

P312 Call a POISON CENTER/doctor/…if you feel unwell.

P342+P311 If experiencing respiratory symptoms: Call a POISON CENTER/doctor/...
Storage     

P403+P233 Store in a well-ventilated place. Keep container tightly closed.

P405 Store locked up.
Disposal     

P501 Dispose of contents/container to ...
2.3 Other hazards which do not result in classification

none
3.Composition/information on ingredients
3.1 Substances
Chemical name     Common names and synonyms     CAS number     EC number     Concentration
trimellitic anhydride     trimellitic anhydride     552-30-7     none     100%
4.First-aid measures
4.1 Description of necessary first-aid measures
General advice

Consult a physician. Show this safety data sheet to the doctor in attendance.
If inhaled

Fresh air, rest. Refer for medical attention.
In case of skin contact

Remove contaminated clothes. Rinse skin with plenty of water or shower.
In case of eye contact

First rinse with plenty of water for several minutes (remove contact lenses if easily possible), then refer for medical attention.
If swallowed

Rinse mouth. Give one or two glasses of water to drink. Refer for medical attention .
4.2 Most important symptoms/effects, acute and delayed

Exposure Routes: inhalation, ingestion, skin and/or eye contact Symptoms: Irritation eyes, skin, nose, respiratory system; pulmonary edema, respiratory sensitization; rhinitis, asthma, cough, wheezing, dyspnea (breathing difficulty), malaise (vague feeling of discomfort), fever, muscle aches, sneezing Target Organs: Eyes, skin, respiratory system (NIOSH, 2016)
4.3 Indication of immediate medical attention and special treatment needed, if necessary

/SRP:/ Basic treatment: Establish a patent airway (oropharyngeal or nasopharyngeal airway, if needed). Suction if necessary. Watch for signs of respiratory insufficiency and assist ventilations if needed. Administer oxygen by nonrebreather mask at 10 to 15 L/min. Monitor for pulmonary edema and treat if necessary ... . Monitor for shock and treat if necessary ... . Anticipate seizures and treat if necessary ... . For eye contamination, flush eyes immediately with water. Irrigate each eye continuously with 0.9% saline (NS) during transport ... . Do not use emetics. For ingestion, rinse mouth and administer 5 ml/kg up to 200 ml of water for dilution if the patient can swallow, has a strong gag reflex, and does not drool ... . Cover skin burns with dry sterile dressings after decontamination ... . /Poisons A and B/
5.Fire-fighting measures
5.1 Extinguishing media
Suitable extinguishing media

Water spray, powder.
5.2 Specific hazards arising from the chemical

This chemical is combustible.
5.3 Special protective actions for fire-fighters

Wear self-contained breathing apparatus for firefighting if necessary.
6.Accidental release measures
6.1 Personal precautions, protective equipment and emergency procedures

Use personal protective equipment. Avoid dust formation. Avoid breathing vapours, mist or gas. Ensure adequate ventilation. Evacuate personnel to safe areas. Avoid breathing dust. For personal protection see section 8.
6.2 Environmental precautions

Personal protection: particulate filter respirator adapted to the airborne concentration of the substance. Sweep spilled substance into covered containers. If appropriate, moisten first to prevent dusting. Carefully collect remainder.
6.3 Methods and materials for containment and cleaning up

Personal protection: P3 filter respirator for toxic particles. Sweep spilled substance into containers; if appropriate, moisten first to prevent dusting. Carefully collect remainder.
7.Handling and storage
7.1 Precautions for safe handling

Avoid contact with skin and eyes. Avoid formation of dust and aerosols. Avoid exposure - obtain special instructions before use.Provide appropriate exhaust ventilation at places where dust is formed. For precautions see section 2.2.
7.2 Conditions for safe storage, including any incompatibilities

Dry. Separated from bases and strong oxidants. Ventilation along the floor.Dry. Separated from bases and strong oxidants. Ventilation along the floor.
8.Exposure controls/personal protection
8.1 Control parameters
Occupational Exposure limit values

Recommended Exposure Limit: 10 Hr Time-Weighted Avg: 0.005 ppm (0.04 mg/cu m). Should be handled in the workplace as an extremely toxic substance.
Biological limit values

no data available
8.2 Appropriate engineering controls

Handle in accordance with good industrial hygiene and safety practice. Wash hands before breaks and at the end of workday.
8.3 Individual protection measures, such as personal protective equipment (PPE)
Eye/face protection

Safety glasses with side-shields conforming to EN166. Use equipment for eye protection tested and approved under appropriate government standards such as NIOSH (US) or EN 166(EU).
Skin protection

Wear impervious clothing. The type of protective equipment must be selected according to the concentration and amount of the dangerous substance at the specific workplace. Handle with gloves. Gloves must be inspected prior to use. Use proper glove removal technique(without touching glove's outer surface) to avoid skin contact with this product. Dispose of contaminated gloves after use in accordance with applicable laws and good laboratory practices. Wash and dry hands. The selected protective gloves have to satisfy the specifications of EU Directive 89/686/EEC and the standard EN 374 derived from it.
Respiratory protection

Wear dust mask when handling large quantities.
Thermal hazards

no data available
9.Physical and chemical properties
Physical state     white to off-white flakes
Colour     Crystals
Odour     no data available
Melting point/ freezing point     6°C(lit.)
Boiling point or initial boiling point and boiling range     88°C
Flammability     Combustible SolidCombustible.
Lower and upper explosion limit / flammability limit     no data available
Flash point     227°C
Auto-ignition temperature     no data available
Decomposition temperature     no data available
pH     no data available
Kinematic viscosity     no data available
Solubility     In water:DECOMPOSES
Partition coefficient n-octanol/water (log value)     no data available
Vapour pressure     <0.01 mm Hg ( 20 °C)
Density and/or relative density     1.54
Relative vapour density     6.6 (vs air)
Particle characteristics     no data available
10.Stability and reactivity
10.1 Reactivity

no data available
10.2 Chemical stability

Stable under recommended storage conditions.
10.3 Possibility of hazardous reactions

Combustible.Dust explosion possible if in powder or granular form, mixed with air. If dry, it can be charged electrostatically by swirling, pneumatic transport, pouring, etc.TRIMELLITIC ANHYDRIDE reacts exothermically with water. This reaction is expected to be slow, but can become vigorous if local heating accelerates it. Reaction with water is accelerated by acids. Incompatible with acids, strong oxidizing agents, alcohols, amines, and bases. Incompatible with strong oxidizing agents, strong acids or strong bases. .
10.4 Conditions to avoid

no data available
10.5 Incompatible materials

Reacts violently with bases and oxidants. Reacts slowly with water to form trimellitic acid.
10.6 Hazardous decomposition products

When heated to decomposition it emits acrid smoke and irritating fumes.
11.Toxicological information
Acute toxicity

    Oral: LD50 Mouse oral 1900 mg/kg
    Inhalation: LC50 Rat inhalation >2330 mg/cu m/4 hr
    Dermal: no data available

Skin corrosion/irritation

no data available
Serious eye damage/irritation

no data available
Respiratory or skin sensitization

no data available
Germ cell mutagenicity

no data available
Carcinogenicity

no data available
Reproductive toxicity

no data available
STOT-single exposure

no data available
STOT-repeated exposure

no data available
Aspiration hazard

no data available
12.Ecological information
12.1 Toxicity

    Toxicity to fish: no data available
    Toxicity to daphnia and other aquatic invertebrates: no data available
    Toxicity to algae: no data available
    Toxicity to microorganisms: no data available

12.2 Persistence and degradability

AEROBIC: Based upon the hydrolysis of trimellitic anhydride in aqueous environments(1), biodegradation is not expected to be a primary removal process in aquatic systems(SRC). A biodegradation study based on BOD measurements, using an activated sludge seed, and an initial chemical concentration of 100 ppm, reported an 89-101% degree of biodegradation over a period of four weeks(2); however this was probably for trimellitic acid since the anhydride hydrolyzes so rapidly(SRC).
12.3 Bioaccumulative potential

Based on the structural similarities to phthalic anhydride, trimellitic anhydride is expected to have a similar hydrolysis rate(SRC). Phthalic anhydride has been reported to hydrolyze rapidly in water(1) and estimated half-lives of approximately 1.5 minutes and 2.7 minutes were calculated(SRC) using reported observed rate constants of 7.9X10-3/sec(2) and 4.3X10-3/sec(3), respectively. Based upon this hydrolysis rate, trimellitic anhydride bioconcentration is not expected to be an important environmental fate process(SRC).
12.4 Mobility in soil

Based on the structural similarities to phthalic anhydride, trimellitic anhydride is expected to have a similar hydrolysis rate(SRC). Phthalic anhydride has been reported to hydrolyze rapidly in water(1) and estimated half-lives of approximately 1.5 minutes and 2.7 minutes were calculated(SRC) using reported observed rate constants of 7.9X10-3/sec(2) and 4.3X10-3/sec(3), respectively. Based upon this hydrolysis rate, trimellitic anhydride adsorption to soil and leaching are not expected to be important processes(SRC).
12.5 Other adverse effects

no data available
13.Disposal considerations
13.1 Disposal methods
Product

The material can be disposed of by removal to a licensed chemical destruction plant or by controlled incineration with flue gas scrubbing. Do not contaminate water, foodstuffs, feed or seed by storage or disposal. Do not discharge to sewer systems.
Contaminated packaging

Containers can be triply rinsed (or equivalent) and offered for recycling or reconditioning. Alternatively, the packaging can be punctured to make it unusable for other purposes and then be disposed of in a sanitary landfill. Controlled incineration with flue gas scrubbing is possible for combustible packaging materials.
14.Transport information
14.1 UN Number
ADR/RID: Not dangerous goods.     IMDG: Not dangerous goods.     IATA: Not dangerous goods.
14.2 UN Proper Shipping Name
ADR/RID: unknown
IMDG: unknown
IATA: unknown
14.3 Transport hazard class(es)
ADR/RID: Not dangerous goods.     IMDG: Not dangerous goods.     IATA: Not dangerous goods.
14.4 Packing group, if applicable
ADR/RID: Not dangerous goods.     IMDG: Not dangerous goods.     IATA: Not dangerous goods.
14.5 Environmental hazards
ADR/RID: no     IMDG: no     IATA: no
14.6 Special precautions for user

no data available
14.7 Transport in bulk according to Annex II of MARPOL 73/78 and the IBC Code

no data available
15.Regulatory information
15.1 Safety, health and environmental regulations specific for the product in question
Chemical name     Common names and synonyms     CAS number     EC number
trimellitic anhydride     trimellitic anhydride     552-30-7     none
European Inventory of Existing Commercial Chemical Substances (EINECS)     Listed.
EC Inventory     Listed.
United States Toxic Substances Control Act (TSCA) Inventory     Listed.
China Catalog of Hazardous chemicals 2015     Not Listed.
New Zealand Inventory of Chemicals (NZIoC)     Listed.
Philippines Inventory of Chemicals and Chemical Substances (PICCS)     Listed.
Vietnam National Chemical Inventory     Listed.
Chinese Chemical Inventory of Existing Chemical Substances (China IECSC)     Listed.