2-(3-hydroxypropoxy)-1,25-dihydroxyvitamin D3
| Price | $1 |
| Package | 1KG |
| Min. Order: | 1KG |
| Supply Ability: | Customized |
| Update Time: | 2019-07-06 |
Product Details
| Product Name: 2-(3-hydroxypropoxy)-1,25-dihydroxyvitamin D3 | CAS No.: 104121-92-8 |
| Min. Order: 1KG | Purity: 99% |
| Supply Ability: Customized | Release date: 2019/07/06 |
SP752
| 2-(3-hydroxypropoxy)-1,25-dihydroxyvitamin D3 Basic information |
| Product Name: | 2-(3-hydroxypropoxy)-1,25-dihydroxyvitamin D3 |
| Synonyms: | 2-(3-hydroxypropoxy)-1,25-dihydroxyvitamin D3;Eldecalcitol;ED-71;Eldecalcitol(ED-71);2.beta.-(3-Hydroxypropoxy)-1.alpha.,25-dihydroxyvitaMin D3;(1R,Z)-5-((E)-2-((1R,7aR)-1-((R)-6-hydroxy-6-methylheptan-2-yl)-7a-methylhexahydro-1H-inden-4(2H)-ylidene)ethylidene)-2-(3-hydroxypropoxy)-4-methylenecyclohexane-1,3-diol;1alpha,25-dihydroxy-2beta-(3-hydroxypropoxy)vitamin D3 |
| CAS: | 104121-92-8 |
| MF: | C30H50O5 |
| MW: | 0 |
| EINECS: | |
| Product Categories: | |
| Mol File: | 104121-92-8.mol |
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| 2-(3-hydroxypropoxy)-1,25-dihydroxyvitamin D3 Chemical Properties |
| Melting point | 126-128℃ |
| density | 1.10 |
| Safety Information |
| MSDS Information |
| 2-(3-hydroxypropoxy)-1,25-dihydroxyvitamin D3 Usage And Synthesis |
| Description | Eldecalcitol (Edirol) was approved in January 2011 by the Japanese Ministry of Health, Labor, and Welfare for the treatment of osteoporosis. Because of vitamin D’s central role in the bone health, vitamin D and analogs of vitamin D have been used to treat patients diagnosed with osteoporosis. Eldecalcitol is an analog of the active form of vitamin D, calcitriol, in which the lower cyclohexane ring contains a hydroxypropyl group. The synthesis of eldecalcitol involves the assembly of two units, a fully protected (3S,4S,5R)-oct-1-en-7-yne-3,4,5-triol and a fused bicyclic system, (R)-6- ((1R,3aR,7aR,E)-4-(bromomethylene)-7a-methyloctahydro-1H-inden-1- yl)-2-methylheptan-2-ol, through a Diels-Alder reaction to give fully protected eldecalcitol. The hydroxyl groups are then deprotected to give the parent molecule. Eldecalcitol binds to the vitaminDreceptor 2.7-fold more potently than calcitriol, while only weakly inhibiting serum parathyroid hormone. |
| Originator | Chugai Pharmaceutical/Roche (Japan) |
| Definition | ChEBI: A hydroxycalciol that is calcitriol with a 3-hydroxypropoxy group at position 2 |
Company Profile Introduction
Established in 2014,Career Henan Chemical Co. is a manufacturerspecializing in the sale of fine chemicals.
Mainly deals in the sales of:
Pharmaceutical intermediates
OLED intermediates：
Pharmaceutical intermediates;
OLED intermediates;
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China- Since: 2014-12-17
- Address: No.967,15th Floor,Unit 7, Building 1, No.70 of DianChang Road, High-tech Development Zone, Zhengzho
INQUIRY
楊俊青
sales@coreychem.com
sales@coreychem.com