Product Details
| Product Name:
Satraplatin |
CAS No.:
129580-63-8 |
| Min. Order:
1KG |
Purity:
99% |
| Supply Ability:
200KG |
Release date:
2019/07/06 |
JD607
| Product Name: |
Satraplatin |
| Synonyms: |
bis(acetato-o)amminedichloro(cyclohexanamine)-pt;platinum (lv) cis-dichloro-trans-bis(acetato-o)ammine(cyclohexanamine);SATRAPLATIN;JM 216;Bis-acetatoamminedichlorocyclohexylamine platinum(iv);C081294;Platinum, bis(acetato-o)amminedichloro(cyclohexanamine)-, (oc-6-43)-;Satraplatin(JM216) |
| CAS: |
129580-63-8 |
| MF: |
C10H22Cl2N2O4Pt |
| MW: |
500.28 |
| EINECS: |
|
| Product Categories: |
Anticancer |
| Mol File: |
129580-63-8.mol |
 |
| |
| Satraplatin Chemical Properties |
| Toxicity |
LD50 in mice (mg/kg): 30 i.p.; 330 orally (Kelland) |
| |
| Satraplatin Usage And Synthesis |
| Uses |
Antineoplastic. |
| Definition |
ChEBI: A platinum coordination entity that consists of a central platunum atom bound to chloro (x2), acetate (x2), amino, and cyclohexylamino groups. Used for treatment of advanced prostate cancer. |
| Pharmaceutical Applications |
Satraplatin (JM216, cis,trans,cis-[PtCl2(OAc)2(NH3)(C6H5NH2)]) is a Pt(IV) or Pt4+ complex, which is active by oral administration, as it is more hydrophobic than cisplatin. This form of administration is very attractive because of the convenience and freedom it provides to the patient. Satraplatin also has a milder toxicity profile and is shows no cross-resistance with cisplatin. Satraplatin in combination with prednisone has completed phase III clinical trials against hormone-refractory prostate cancer. The results were very encouraging, but the overall survival rate did not improve significantly enough. As a result, the fast-track approval of the FDA was not granted.
Structurally, satraplatin consists of a Pt(IV) centre, which is coordinated by six ligands forming a close to octahedral geometry. In general, octahedral Pt(IV) complexes (low-spin d6) are much more kinetically inert than square planar Pt(II) complexes. |
Company Profile Introduction
Established in 2014,Career Henan Chemical Co. is a manufacturerspecializing in the sale of fine chemicals.
Mainly deals in the sales of:
Pharmaceutical intermediates
OLED intermediates：
Pharmaceutical intermediates;
OLED intermediates;
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