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Postion:Product Catalog >6-THIO-2'-DEOXYGUANOSINE
6-THIO-2'-DEOXYGUANOSINE
  • 6-THIO-2'-DEOXYGUANOSINE

6-THIO-2'-DEOXYGUANOSINE

Price Get Latest Price
Package 25kg
Min. Order: 1kg
Supply Ability: 10000KGS
Update Time: 2025-05-12

Product Details

Product Name: 6-THIO-2'-DEOXYGUANOSINE CAS No.: 789-61-7
Min. Order: 1kg Purity: 99%
Supply Ability: 10000KGS Release date: 2025/05/12

Product Description:

Our Reference Specification, for more details, pls contact us for COA,MSDS and certification:

Email & Skype: 1023@dideu.com Telephone:+86-29-89586680

Mobile/Whatsapp/Wechat: +8618192503167

UsesGuanosine (G837900) derivative with cancer chemotherapeutic properties. It is involved in the inhibition of human RNase H-mediated RNA cleavage from DNA-RNA duplexes via incorporation into DNA.
Biological Activity6-thio-dg is a nucleoside analogue [1], is a telomerase-mediated telomere disrupting compound [2]. it is an anti-cancer inhibitor [1]. cancer cells were very sensitive to 6-thio-dg with observed ic50 values ranging from 0.7-2.9 μm, depending on cell types [3].telomeres are found at the end of eukaryotic linear chromosomes. they are essential for genomic stability and chromosome maintenance [3].in hct116 human colon cancer cell line, treatment with 6-thio-dg made progressive telomere shortening independent of telomerase activity inhibition and induced telomere dysfunction. grn163l is a telomerase inhibitor. in hct116 cells, treatment with grn163l and 6-thio-dg together increased telomere shortening. within 1 week, 6-thio-dg killed most of hct116 cells and altered cellular morphology. normal bj fibroblast cells are telomerase silent. after 1 week, treatment with 6-thio-dg showed no effect on cell morphology. after long-term treatment with 6-thio-dg, no effect on telomere shortening was found [1].in murine mode with xenograft derived from a549 lung cancer cell line, as compared to controls, intraperitoneal injection with 2 mg/kg of 6-thio-dg every other day completely prevented progressive tumor growth. ki67 is a biomarker correlating with proliferation levels. compared to controls, 6-thio-dg decreased ki67 staining. treatment with 6-thio-dg through local injection resulted in even more dramatic decrease in the tumor growth rate compared to untreated controls [3].

Packaging & Shipping:

Our normal packaging is 25kgs/Drum

The packaging can be customized. the shipping term can be by sea, by air, and sample or small quantity can be shipped by DHL, FEDEX, EMS and TNT.

Our Services:

a) Free sample can be supplied.

b) Guide our clients by professional knowledge and teach them how to use our product after sales.

c) Accept SGS,BV any other third-party inspection before loading.

d) High quality best price Guaranteed.

FAQ:

Why do you choose Dideu as your partner?

A) High quality can be guaranteed. Dideu Industries since 1975 are reputed chemical manufacturer and are Certified by ISO 9001; 2015 and have GMP certification. Free sample can be arranged before shipment and SGS, BV and other third party inspection company are accepted before loading. For regular customers, we accept L/C 180 Days, D/P, D/A payment term. If there is any quality problem after goods arrive. Dideu Industries will do fully payment refund.


B) Best price can be guaranteed. As Dideu Industries are integrated pharmaceuticals and chemicals producer, the production cost can be controlled and price will be definitely more competitive than China trading companies.


C) Professional enginners from Dideu Industries will give professional usage guide and services after sales.


D)Dideu Industries work 7×24 hours and your request will be processed by our professional staff in different shift period.






Company Profile Introduction

Dideu is a high-tech enterprise, which excels in the fields of R&D, production and sales, making it a pioneer in cutting-edge technologies. With a focus on pharmaceutical and small molecule drugs R&D, pharmaceutical intermediates, new bio-based molecules and materials, biopharmaceuticals, genetic engineering bacterial biosynthesis enzymes, CMO/CDMO custom chemicals and liquid crystal OLED materials. Dideu has witnessed rapid growth in recent years, with thriving businesses in original drug research, biopharmaceuticals, biodegradable materials and pharmaceutical intermediates. Dideu always takes on some of the human biggest healthcare challenges. It delivers a sustainable business and health benefits to patients through its high quality products. Dideu develops a broad range of products in pharmaceuticals, vaccines and consumer healthcare, and has leading products across various therapeutic areas including cardiovascular and respiratory disease,neurological disorders, asthma, cancer, infections, mental health, gastrointestinal infection,diabetes and digestive conditions. It is one of the best companies to have a good growth in emerging markets recent years; Dideu is improving people’s quality of life by preventing, alleviating and treating diseases. And we are also have subsidiary company helping to provide a reliable supply of high quality green agrucutural chemical, high-quality food, feed and plant-based raw materials.We develop new molecules for use in innovative products and solutions to improve health. Our research and development activities are based on a profound understanding of the biochemical processes in living organisms.Our goal is to achieve and sustain leadership positions in our markets, thus creating value for our customers, stockholders and employees. To this end, our strategy is designed to help solve some of the most pressing challenges facing humankind, and by doing this exceptionally well we aim to strengthen the company’s earning power. We

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  • Since: 2020-12-28
  • Address: No.99 Gangwu Avenue, International Port District, Xi'an City, Shaanxi Province, China
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