![[6]-Gingerol](/ProductImageEN1/2024-11/Large/b7d42100-9f96-4565-aea0-2742a854aee9.png)
![[6]-Gingerol](/ProductImageEN1/2024-11/Small/b7d42100-9f96-4565-aea0-2742a854aee9.png)
[6]-Gingerol NEW
| Price | $35 | $50 | $81 |
| Package | 5mg | 10mg | 25mg |
| Min. Order: | |
| Supply Ability: | 10g |
| Update Time: | 2024-11-19 |
Product Details
| Product Name: [6]-Gingerol | CAS No.: 23513-14-6 |
| Purity: 99.59% | Supply Ability: 10g |
| Release date: 2024/11/19 |
Product Introduction
Bioactivity
| Name | [6]-Gingerol |
| Description | [6]-Gingerol ((S)-(+)-[6]Gingerol), an antioxidant, protects HL-60 cells from oxidative stress. It has protective effects for Yous tumors in the pancreas, ovaries, breast tissue, the bowel, among other tissues. |
| Cell Research | [6]-gingerol stock (20 mg/mL) is prepared in ethanol and the working concentrations are prepared by diluting this stock in dimethyl sufoxide (DMSO). For MTT assay, 5×103 cells/well of human colon cancer cells and 104 cells/well of mouse IECs are seeded in 96-well plates. Cells are treated with [6]-gingerol for 48 h,72 h or 96 h before performing MTT assay and for 16 h before Annexin-V staining[1]. |
| In vitro | [6]-Gingerol selectively inhibits proliferation and induces apoptosis in colon cancer cells while sparing normal colon cells. It modulates cell signaling by down-regulating phorbol myristate acetate-induced phosphorylation of ERK1/2 and JNK MAP kinases and reducing AP-1 transcription factor activation, with minimal impact on p38 MAP kinase phosphorylation and NF-kappa B activation[1]. Moreover, [6]-gingerol enhances intestinal barrier function and diminishes proinflammatory responses in DSS-treated Caco-2 monolayers, partly by activating AMPK[2]. Additionally, it significantly reduces osteosarcoma cell viability in a dose-dependent manner, increases sub-G1 cell cycle arrest, and activates caspase cascades while adjusting Bcl2 and Bax protein levels[3]. |
| In vivo | In animal studies, [6]-gingerol effectively mitigates DSS-induced colitis symptoms by reversing body weight loss, decreasing intestinal bleeding, and preventing colon shortening. It also inhibits the DSS-induced increase in proinflammatory cytokines (IL-1β, TNFα, and IL-12)[2]. |
| Storage | store at low temperature,keep away from direct sunlight | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice. |
| Solubility Information | Chloroform, Dichloromethane, Ethyl Acetate, Acetone, etc. : Soluble DMSO : 50 mg/mL (169.84 mM), Sonication is recommended. |
| Keywords | AMP-activated protein kinase | Apoptosis | inhibit | [6] Gingerol | [6]-Gingerol | AMPK | [6]Gingerol | Inhibitor |
| Inhibitors Related | Stavudine | 5-Fluorouracil | Myricetin | Dextran sulfate sodium salt (MW 4500-5500) | Sodium 4-phenylbutyrate | L-Ascorbic acid | Metronidazole | Sorafenib | Tributyrin | Salicylic acid | Oleic acid | Chitosan oligosaccharide |
| Related Compound Libraries | Marine Natural Product Library | Selected Plant-Sourced Compound Library | Kinase Inhibitor Library | Natural Product Library | Anti-Inflammatory Traditional Chinese Medicine Compound Library | Natural Product Library for HTS | Anti-Aging Compound Library | Ancient Chinese Classical Formulas Compound Library | Food as Medicine Compound Library | Anti-Cancer Active Compound Library |
Company Profile Introduction
Target Molecule Corp. (TargetMol) is a global high-tech enterprise, headquartered in Boston, MA, specializing in chemical and biological research product and service to meet the research needs of global customers.
TargetMol has evolved into one of the biggest global compound library and small molecule suppliers and a customer based on 40+ countries. TargetMol offers over 80 types of compound libraries and a wide range of high-quality research chemicals including inhibitors, activator, natural compounds, peptides, inhibitory antibodies, and novel life-science kits, for laboratory and scientific use. Besides, virtual screening service is also available for customers who would like to conduct the computer-aided drug discovery.
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United States- Since: 2011-01-07
- Address: 36?Washington?Street, Wellesley?Hills
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