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Postion:Product Catalog >API>Inhibitors>Afatinib (BIBW 2992)
Afatinib (BIBW 2992)
  • Afatinib (BIBW 2992)

Afatinib (BIBW 2992)

Price $1
Package 1g
Min. Order: 1g
Supply Ability: 1000kgs
Update Time: 2019-07-31

Product Details

Product Name: Afatinib (BIBW 2992) CAS No.: 439081-18-2
Min. Order: 1g Purity: 99%
Supply Ability: 1000kgs Release date: 2019/07/31

Small-Molecule Targeted Anti Tumor Inhibitor API  Afatinib 
(CAS: 439081-18-2)

Chemical Information
Quick Details:

Product Name Afatinib
Molecular Formula C24H25ClFN5O3
Molecular Weight 485.94
Storage 3years in -20ºC
Targets Abl c-Src
Dosage 30 nM; intraperitoneal injection
Target EGFR (L858R) EGFR (wt) EGFR (L858R/T790M) HER2
IC50 0.4 nM 0.5 nM 10 nM 14 nM

Product Name: Afatinib
Other Names:Afatinib;(2E)-N-[4-[(3-Chloro-4-fluorophenyl)amino]-7-[[(3S)-tetrahydro-3-furanyl]oxy]-6-quinazolinyl]-4-(dimethylamino)-2-butenamide;4-[(3-chloro-4-fluorophenyl)aMino]-6-{[4-(N,N-diMethylaMino)-1-oxo-2-buten-1-yl]aMino}-7-((S)-tetrahydrofuran-3-yloxy)-quinazoline;2-ButenaMide, N-[4-[(3-chloro-4-fluorophenyl)aMino]-7-[[(3S)-tetrahydro-3-furanyl]oxy]-6-quinazolinyl]-4-(diMethylaMino)-, (2E)-;(S,E)-N-(4-((3-Chloro-4-fluorophenyl)amino)-7-((tetrahydrofuran-3-yl)oxy)quinazolin-6-yl)-4-(dime;Afatinib API;Afatinib(BIBW2992MA2);Afatinib (with 1 int.)
Model No.: ATC-136
CAS No.: 439081-18-2
Molecular Formula: C24H25ClFN5O3
Molecular Weight: 485.94
Appearance: White or Nearly White Crystalline Powder
Purity: 99%+
Product Specifications: Pharmaceutical Grade
        
Product Description
Afatinib (INN; trade name Gilotrif in the US and Giotrif in Europe, previously Tomtovok and Tovok) is a drug approved in United States, Europe, Taiwan, Mexico, Chile and Japan as well as other countries for the first-line treatment of patients with distinct types of metastatic (EGFR mutation positive) non-small cell lung carcinoma (NSCLC), developed by Boehringer Ingelheim. It acts as an irreversible covalent inhibitor of the receptor tyrosine kinases epidermal growth factor receptor (EGFR) and erbB-2 (HER2).

Applications/Usage
It has received regulatory approval for use as a treatment for non-small cell lung cancer, although there is emerging evidence to support its use in other cancers such as breast cancer.

COA Report:

Item

Requirements

Test Results

Description

Off-white powder

Off-white powder

Identification

HPLC ,NMR

Complies

Residue on Ignition

≤0.10%

0.05%

Loss on Drying

≤0.50%

0.15%

Heavy Metal

≤20ppm

<20ppm

Purity(HPLC)

≥99.0%

99.99%

Conclusion

It complies with EnterpriseStandard


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