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Postion:Product Catalog >Biochemical Engineering>Inhibitors>Metabolism>P450 (e.g. CYP17) inhibitor>Cobicistat
Cobicistat
  • Cobicistat
  • Cobicistat

Cobicistat

Price $2
Package 1kg
Min. Order: 1kg
Supply Ability: 100kg
Update Time: 2019-07-06

Product Details

Product Name: Cobicistat CAS No.: 1004316-88-4
Min. Order: 1kg Purity: 99%
Supply Ability: 100kg Release date: 2019/07/06
Product NUmber: : WM.562
 
Cobicistat Basic information
Description In vitro
Product Name: Cobicistat
Synonyms: Cobicistat;Cobicistat (GS-9350);thiazol-5-ylMethyl (2R,5R)-5-((S)-2-(3-((2-isopropylthiazol-4-yl)Methyl)-3-Methylureido)-4-MorpholinobutanaMido)-1,6-diphenylhexan-2-ylcarbaMate;GS 9350;GS9350;GS-9350;Cobicistat D8;(3R,6R,9S)-12-Methyl-13-[2-(1-methylethyl)-4-thiazolyl]-9-[2-(4-morpholinyl)ethyl]-8,11-dioxo-3,6-bis(phenylmethyl)-2,7,10,12-tetraazatridecanoic acid 5-thiazolylmethyl ester
CAS: 1004316-88-4
MF: C40H53N7O5S2
MW: 776.02272
EINECS:  
Product Categories: Inhibitor;Inhibitors
Mol File: 1004316-88-4.mol
Article illustration
 
Cobicistat Chemical Properties
density  1.228±0.06 g/cm3 (20 ºC 760 Torr)
 
Safety Information
MSDS Information
 
 
Cobicistat Usage And Synthesis
Description Cobicistat (GS-9350) is a potent and selective inhibitor of CYP3A with IC50 of 30-285 nM.
In vitro Cobicistat (GS-9350) is a potent, and selective inhibitor of human cytochrome P450 3A (CYP3A) enzymes as a pharmacoenhancer. GS-9350 inhibits CYP3A with IC50 spectrum from 30 nM to 285 nM. In contrast to ritonavir, GS-9350 is devoid of anti-HIV activity, with IC50 of > 30μM against HIV-1 protease and EC50 of > 30μM in MT-2 HIV infection assay, and is thus more suitable for use in boosting anti-HIV drugs without risking selection of potential drug-resistant HIV variants. GS-9350 shows reduced liability for drug interactions and may have potential improvements in tolerability over ritonavir.
Uses Cobicistat is a HIV protease inhibitor and have been coadministered with low-dose ritonavir (R535000) as a pharmacoenhancer, significantly increasing their plasma concentrations.
Uses Isotope labelled analogue of Cobicistat (C633150), a HIV protease inhibitor and have been coadministered with low-dose ritonavir (R535000) as a pharmacoenhancer, significantly increasing their plasma concentrations.
Uses Antiretroviral;Labeled Cobicistat, intended for use as an internal standard for the quantification of Cobicistat by GC- or LC-mass spectrometry.

Company Profile Introduction

Established in 2014,Career Henan Chemical Co. is a manufacturerspecializing in the sale of fine chemicals. Mainly deals in the sales of: Pharmaceutical intermediates OLED intermediates: Pharmaceutical intermediates; OLED intermediates;

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  • Since: 2014-12-17
  • Address: No.967,15th Floor,Unit 7, Building 1, No.70 of DianChang Road, High-tech Development Zone, Zhengzho
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