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Postion:Product Catalog >Biochemical Engineering>Inhibitors>Immunosuppressants>TACROLIMUS
TACROLIMUS
  • TACROLIMUS

TACROLIMUS

Price $1
Package 1kg
Min. Order: 1kg
Supply Ability: Customized
Update Time: 2019-07-06

Product Details

Product Name: TACROLIMUS CAS No.: 109581-93-3
Min. Order: 1kg Purity: 99.99%
Supply Ability: Customized Release date: 2019/07/06

SP320

 

TACROLIMUS Basic information
Product Name: TACROLIMUS
Synonyms: FK-506;,8s*,9e,12r*,14r*,15s*,16r*,18s*,19s*,26ar*))-;18-tetramethyl-8-(2-propenyl)-,monohydrate,(3s-(3r*(e(1s*,3s*,4s*)),4s*,5r*;3-(2-(4-hydroxy-3-methoxycyclohexyl)-1-methylethenyl)-14,16-dimethoxy-9,10,12,;tacrolimushydrate;tsukubaenolidehydrate;FK-506 MONOHYDRATE;Tacarolimus
CAS: 109581-93-3
MF: C44H69NO12
MW: 822.04
EINECS:  
Product Categories: Signalling
Mol File: 109581-93-3.mol
Article illustration
 
TACROLIMUS Chemical Properties
Melting point  127-129°
alpha  D23 -84.4° (c = 1.02 in chloroform)
storage temp.  −20°C
solubility  DMSO: soluble20mg/mL
Merck  14,9025
 
Safety Information
Hazard Codes  T
Risk Statements  25
Safety Statements  45
RIDADR  UN 2811 6.1/PG 3
RTECS  KD4201200
HazardClass  6.1
PackingGroup  III
Toxicity LD50 i.p. in mice: >200 mg/kg (Kino); LD50 in male, female rats (mg/kg): 57.0, 23.6 i.v.; 134, 194 orally (Ohara)
MSDS Information
 
 
TACROLIMUS Usage And Synthesis
Uses immune suppressant, antifungal
Definition ChEBI: A hydrate that is the monohydrate form of tacrolimus.
Biological Activity Potent calcineurin (protein phosphatase 2B) inhibitor that requires FK 506-binding protein 12 (FKBP12) for activity (IC 50 = 3 nM). Inhibits secretion of IL-1, IL-2 (IC 50 = 1 nM), IL-3, IL-4, IL-6 (IC 50 = 35 nM), GM-CSF, TNF α (IC 50 = 10 nM), IFN γ and Myc from activated T-cells in vitro . Exhibits potent immunosuppressive, neuroprotective and anticonvulsant activity in vivo .

Company Profile Introduction

Established in 2014,Career Henan Chemical Co. is a manufacturerspecializing in the sale of fine chemicals. Mainly deals in the sales of: Pharmaceutical intermediates OLED intermediates: Pharmaceutical intermediates; OLED intermediates;

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