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Postion:Product Catalog >API>Antineoplastic agents>Other antineoplastic Drugs> Mitotan
	Mitotan
  • 	Mitotan

Mitotan

Price $1
Package 1KG
Min. Order: 1G
Supply Ability: 100KG
Update Time: 2019-07-06

Product Details

Product Name: Mitotan CAS No.: 53-19-0
Min. Order: 1G Purity: 98%
Supply Ability: 100KG Release date: 2019/07/06

AD68

Product Name: Mitotan
Synonyms: LYSODREN;CB-313;'LGC' (1126);2-(2-CHLOROPHENYL)-2-(4-CHLOROPHENYL)-1,1-DICHLOROETHANE;2,2-(2-chlorophenyl)-2-(4-chlorophenyl)-1,1-dichloroethane;2,4'-TDE;2,4'-DDD;(2,4'-DICHLORODIPHENYL)DICHLOROETHANE
CAS: 53-19-0
MF: C14H10Cl4
MW: 320.04
EINECS: 200-166-6
Product Categories: Organics;Intermediates & Fine Chemicals;Pharmaceuticals;API;LYSODREN
Mol File: 53-19-0.mol
Article illustration
 
Mitotan Chemical Properties
Melting point  77-78 °C(lit.)
Boiling point  405.59°C (rough estimate)
density  1.3118 (rough estimate)
refractive index  1.6000 (estimate)
storage temp.  APPROX 4°C
solubility  DMSO: soluble20mg/mL, clear
color  white to beige
Water Solubility  <0.1 g/100 mL at 24 ºC
Merck  13,6237 / 13,6237
CAS DataBase Reference 53-19-0(CAS DataBase Reference)
NIST Chemistry Reference Mitotane(53-19-0)
EPA Substance Registry System Benzene, 1-chloro-2-[2,2-dichloro-1-( 4-chlorophenyl)ethyl]-(53-19-0)
 
Safety Information
Hazard Codes  Xn
Risk Statements  40
Safety Statements  36/37
RIDADR  3249
WGK Germany  3
RTECS  KH7880000
HazardClass  6.1(b)
PackingGroup  III
Hazardous Substances Data 53-19-0(Hazardous Substances Data)
Mitotan Usage And Synthesis
Pharmacological effects Mitotan is structurally similar with insecticide DDT and DDD and can selectively cause the atrophy and necrosis of adrenal cortex-zona fasciculata and reticularis cells but without affecting the zona, therefore the secretion of aldosterone will not affected. After the drug administration, the cortisol and its metabolites level in blood and urine decreased rapidly after treatment. At the same time, the in vivo adrenocorticotropic hormone and metabolite products level also decrease rapidly. It is suitable for the treatment of inoperable, functional and non-functional adrenal cortical carcinoma, adrenal tumor, adrenal hyperplasia-caused Klinefelter’s syndrome, adrenal hyperplasia, and the adjuvant therapy of postoperation cortical cancer and tumor-induced Cushing's syndrome. 
After oral administration, about 40% of Mitotan is absorbed through the gastrointestinal tract with the remaining 60% of the prototype excreted together with the feces. At a dose of 5~10 g daily, the plasma concentration can be up to 10~90μg/ml, the concentration of metabolites can be up to 30~50μg/ml. At 6-9 weeks after discontinuation, it can be still detected of o-alkyl chloride in the plasma. Mitotan has a high fat-solubility and is mainly stored in fat. The water soluble metabolites discharged from the urine can account for about 25% of the administered dose. 
The above information is edited by the chemicalbook of Dai Xiongfeng.
Chemical Properties It appears as white crystals with the melting point being 76-78 ℃. It is soluble in ethanol and carbon tetrachloride.
Uses It belongs to antineoplastic agents and can be used for the treatment of adrenal cortical carcinoma.
Production method It can be prepared from O-bromo-chlorobenzene (see 05820) by the following steps.
Category Toxic substances.
Toxicity grading Poisoning.
Acute toxicity Oral-rat; LD50> 5000 mg/kg; Oral-Mouse LD50> 4000 mg/kg.
Flammability and hazard properties Thermal decomposition can release toxic chloride fume.
Storage characteristics Low-temperature, dry and ventilated warehouse.
Extinguishing media Water, carbon dioxide, foam, powder.
Chemical Properties Crystalline Solid
Uses insecticide, antineoplastic
Uses aminobiphoshphanate for treatment of osteoporosis and Paget's bone disease
Uses An Antineoplastic. Used as an adrenolytic agent
Uses Mitotane is an inhibitor of steroidogenesis that suppresses the growth of adrenocortical cells. It blocks the expression of several genes that encode proteins involved in steroidogenesis and disrupts mitochondrial respiratory chain activity in human adrenocortical cells. Mitotane has anti-neoplastic actions, alone or in combination with other compounds, and suppresses cortisol synthesis, although it also has significant toxicity in the gastrointestinal tract and nervous system. It is effective against adrenocortical carcinoma and Cushing’s Syndrome in clinical trials.
General Description Colorless powder.
Air & Water Reactions Insoluble in water.
Reactivity Profile Mitotan dehydrohalogenates with strong alkalis. Simple aromatic halogenated organic compounds are very unreactive; halogenated aliphatic compounds are moderately or very reactive. For both subgroups, reactivity generally decreases with increased degree of substitution of halogen for hydrogen atoms. Materials in this group are incompatible with strong oxidizing and reducing agents. Also, they are incompatible with many amines, nitrides, azo/diazo compounds, alkali metals, and epoxides.
Fire Hazard Flash point data for Mitotan are not available. Mitotan is probably combustible.
 

Company Profile Introduction

Established in 2014,Career Henan Chemical Co. is a manufacturerspecializing in the sale of fine chemicals. Mainly deals in the sales of: Pharmaceutical intermediates OLED intermediates: Pharmaceutical intermediates; OLED intermediates;

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  • Since: 2014-12-17
  • Address: No.967,15th Floor,Unit 7, Building 1, No.70 of DianChang Road, High-tech Development Zone, Zhengzho
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