Fexofenadine hydrochloride
| Price | $1 |
| Package | 1KG |
| Min. Order: | 1G |
| Supply Ability: | 100KG |
| Update Time: | 2019-07-06 |
Product Details
| Product Name: Fexofenadine hydrochloride | CAS No.: 153439-40-8 |
| Min. Order: 1G | Purity: 98% |
| Supply Ability: 100KG | Release date: 2019/07/06 |
AD68
| Fexofenadine hydrochloride Basic information |
| Description References |
| Product Name: | Fexofenadine hydrochloride |
| Synonyms: | α,α-dimethyl-4-[1-hydroxy-4-[4-(hydroxydiphenylmethyl)-1-piperidinyl]butyl]benzeneacetic acid;Benzeneacetic acid, 4-[1-hydroxy-4-[4-(hydroxydiphenylmethyl)-1-piperidinyl]butyl]-α,α-dimethyl-, hydrochloride;MDL 16455A;Telfast;Telfast BD;2-[4-[1-Hydroxy-4-[4-(hydroxy-diphenyl-methyl)-1-piperidyl]-butyl]phenyl]-2-methyl-propanoic acid hydrochloride;Allegra;Fexofenadine hydrochloride |
| CAS: | 153439-40-8 |
| MF: | C32H40ClNO4 |
| MW: | 538.12 |
| EINECS: | 1308068-626-2 |
| Product Categories: | Intermediates & Fine Chemicals;Metabolites;Pharmaceuticals;Aromatics;Heterocycles;Metabolites & Impurities;API |
| Mol File: | 153439-40-8.mol |
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| Fexofenadine hydrochloride Chemical Properties |
| Melting point | 148-150oC |
| RTECS | CY1633377 |
| storage temp. | −20°C |
| solubility | Soluble in Dimethyl sulfoxide (50 mM), and methanol. |
| color | white to beige |
| Merck | 14,4068 |
| InChIKey | RRJFVPUCXDGFJB-UHFFFAOYSA-N |
| CAS DataBase Reference | 153439-40-8(CAS DataBase Reference) |
| Safety Information |
| Hazard Codes | Xi |
| Risk Statements | 36/37/38 |
| Safety Statements | 26-36 |
| MSDS Information |
| Fexofenadine hydrochloride Usage And Synthesis |
| Description | Fexofenadine hydrochloride (trade name: Allegra) belongs to a second-generation antihistamine pharmaceutical drug. It is mainly used for the treatment of allergy symptoms including watery eyes, hay fever, nasal congestion, urticaria, runny nose, itching eyes/nose, sneezing, hives, and itching. It is a kind of selectively peripheral H1 blocker. Its mechanism of action in vivo is through preventing the histamine-mediated activation of the H1 receptors, thus alleviating the symptoms related to allergy. Compared to the first-generation antihistamine drug, it is less prone to penetrate the blood-brain barrier, reducing the possibility to cause side effects such as drowsiness. |
| References | http://www.rxlist.com/allegra-drug/consumer-uses.htm https://en.wikipedia.org/wiki/Fexofenadine |
| Chemical Properties | Off-White Crystalline Solid |
| Uses | A metabolite of of terfenadine, a H1-Histamine receptor antagonist |
| Uses | The active metabolite of Terfenadine (T114500), a H1-histamine receptor antagonist. |
| Uses | Antihistaminic;histamine H1-receptor antagonist |
| Uses | Fexofenadine is a non-sedating antihistamine that selectively antagonizes the histamine H1 receptor with a Ki value of 10 nM and exhibits anti-inflammatory effects. It is devoid of central nervous system effects in part because it is a good substrate for the P-glycoprotein efflux pump situated within the blood-brain barrier.[Cayman Chemical] |
| Biological Activity | Selective histamine H 1 receptor antagonist (pK i = 8.1). Active metabolite of terfenadine that displays non-sedating antiallergic effects. |
Company Profile Introduction
Established in 2014,Career Henan Chemical Co. is a manufacturerspecializing in the sale of fine chemicals.
Mainly deals in the sales of:
Pharmaceutical intermediates
OLED intermediates：
Pharmaceutical intermediates;
OLED intermediates;
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China- Since: 2014-12-17
- Address: No.967,15th Floor,Unit 7, Building 1, No.70 of DianChang Road, High-tech Development Zone, Zhengzho
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楊俊青
sales@coreychem.com
sales@coreychem.com