Riluzole
| Price | $1 |
| Package | 1KG |
| Min. Order: | 1G |
| Supply Ability: | 100KG |
| Update Time: | 2019-07-06 |
Product Details
| Product Name: Riluzole | CAS No.: 1744-22-5 |
| EC-No.: 1592732-453-0 | Min. Order: 1G |
| Purity: 98% | Supply Ability: 100KG |
| Release date: 2019/07/06 |
AD68
| Riluzole Basic information |
| Description References |
| Product Name: | Riluzole |
| Synonyms: | 2-Amino-6-(trifluoromethoxy)-1,3-benzothiazole 97%;2-Amino-6-(trifluoromethoxy)-1,3-benzothiazole97%;Riluzole(GMPofSFDA);CBI-BB ZERO/001785;BUTTPARK 13\02-09;6-TRIFLUOROMETHOXYBENZOTHIAZOLE-2-YL-AMINE;6-(TRIFLUOROMETHOXY)-1,3-BENZOTHIAZOL-2-AMINE;6-TRIFLUOROMETHOXY-BENZOTHIAZOL-2-YLAMINE |
| CAS: | 1744-22-5 |
| MF: | C8H5F3N2OS |
| MW: | 234.2 |
| EINECS: | 1592732-453-0 |
| Product Categories: | Neuroprotective;Inhibitors;Intermediates & Fine Chemicals;Pharmaceuticals;GABA/Glycine receptor;Glutamate;Amines;Heterocycles;Sulfur & Selenium Compounds;RILUTEK |
| Mol File: | 1744-22-5.mol |
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| Riluzole Chemical Properties |
| Melting point | 116-118°C |
| storage temp. | Store at RT |
| solubility | DMSO: ≥25 mg/mL |
| form | solid |
| color | white |
| Merck | 14,8223 |
| InChIKey | FTALBRSUTCGOEG-UHFFFAOYSA-N |
| Safety Information |
| Hazard Codes | T,Xi |
| Risk Statements | 25 |
| Safety Statements | 45 |
| RIDADR | UN 2811 6.1/PG 3 |
| WGK Germany | 3 |
| RTECS | DL2830000 |
| Hazard Note | Irritant |
| HazardClass | IRRITANT |
| HazardClass | 6.1 |
| PackingGroup | II |
| HS Code | 29342000 |
| Toxicity | LD50 in mice (mg/kg): 46 i.p.; 67 orally (Mizoule) |
| Riluzole Usage And Synthesis |
| Description | Riluzole belongs to the derivative of benzothiazole with neuroprotective, potential anti-depressant and anxiolytic activities, which is used in the treatment of a certain type of nerve disease called amyotrophic lateral sclerosis (ALS, also known as Lou Gehrig's disease). It is effective to delay the onset of ventilator-dependence or tracheostomy in selected patients, slow down the deterioration of this disease and probably prolong survival by approximately two to three months. Besides, studies have proved that riluzole has anti-depressant activity for refractory depression and serves as an anxiolytic in the treatment of obsessive-compulsive disorder and generalized anxiety disorder. However, riluzole does not cure the ALS and reverse nerve damage or muscle weakness. It is believed to function as an inhibitor of a natural substance called glutamate. It helps protect the nerves in the brain and spinal cord from too much of glutamate which may contribute to the nerve damage. Riluzole is available in both tablet and liquid form. The liquid formulation may be more suitable for patients with swallowing difficulties. |
| References | https://en.wikipedia.org/wiki/Riluzole http://www.medicinenet.com/riluzole_oral_tablets/article.htm https://pubchem.ncbi.nlm.nih.gov/compound/5070#section=Top |
| Chemical Properties | White Crystalline Solid |
| Uses | A neuroprotective agent. Modulates glutamatergic transmission. A glutamate release inhibitor. An anticonvulsant. |
| Uses | anticonvulsant, glutamate release inhibitor, anti-ALS |
| Uses | Labeled Riluzole, intended for use as an internal standard for the quantification of Riluzole by GC- or LC-mass spectrometry. |
| Uses | A neuroprotective agent. A glutamate release inhibitor. An anticonvulsant |
| Biological Activity | Novel psychotropic agent with anticonvulsant, hypnotic, anxiolytic, anti-ischemic and anesthetic properties. Riluzole is able to act as a glutamate release inhibitor, blocks voltage-dependent Na + channels and inhibits GABA uptake by striatal synaptosomes. |
Company Profile Introduction
Established in 2014,Career Henan Chemical Co. is a manufacturerspecializing in the sale of fine chemicals.
Mainly deals in the sales of:
Pharmaceutical intermediates
OLED intermediates：
Pharmaceutical intermediates;
OLED intermediates;
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China- Since: 2014-12-17
- Address: No.967,15th Floor,Unit 7, Building 1, No.70 of DianChang Road, High-tech Development Zone, Zhengzho
INQUIRY
楊俊青
sales@coreychem.com
sales@coreychem.com