4-Hydroxynonenal NEW
| Price | $48 | $98 | $171 |
| Package | 1mg | 5mg | 10mg |
| Min. Order: | |
| Supply Ability: | 10g |
| Update Time: | 2024-11-18 |
Product Details
| Product Name: 4-Hydroxynonenal | CAS No.: 75899-68-2 |
| Purity: 95.12% | Supply Ability: 10g |
| Release date: 2024/11/18 |
Product Introduction
Bioactivity
| 名稱(chēng) | 4-Hydroxynonenal |
| 描述 | 4-Hydroxynonenal (4-HNE) (4-HNE) is an oxidative/nitrosative stress biomarker. It is a substrate and an inhibitor of acetaldehyde dehydrogenase 2 (ALDH2). |
| 體外活性 | 4-Hydroxynonenal (4-HNE) is both a substrate and an inhibitor of ALDH2, with inhibition reversible at low concentrations and becoming irreversible at 10 μM. It induces antioxidant defense mechanisms to limit its own production and enhance cellular protection against oxidative stress. As a product of lipid peroxidation, 4-HNE is mutagenic and genotoxic in viruses, bacteria, and mammalian cells, reacting with all four DNA bases with varying efficiency (G > C > A > T). 4-Hydroxynonenal-dG serves as the best biomarker of its genotoxic effects, primarily found in nuclear DNA [1]. |
| 體內(nèi)活性 | Twenty-four hours after fluid percussion injury (FPI), mouse brain tissue is analyzed for the expression levels of NADPH oxidase 1 (NOX1), inducible nitric oxide synthase (iNOS), and 4-Hydroxynonenal (4-HNE). Both wild-type (Nrf2+/+) and Nrf2-deficient (Nrf2-/-) mice show increased 4-HNE expression following a moderate 15 psi injury compared to uninjured controls. In Nrf2-/-knockout mice, 4-HNE expression is significantly higher than in corresponding injured and uninjured Nrf2-/-wild-type animals [2]. |
| 存儲(chǔ)條件 | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice. |
| 溶解度 | DMSO : 249 mg/mL (1593.91 mM) |
| 關(guān)鍵字 | biomarker | genotoxic | oxidative | Inhibitor | stress | Cancer | Aldehyde Dehydrogenase (ALDH) | Endogenous Metabolite | 4Hydroxynonenal | 4-Hydroxynonenal | nitrosative | mitochondria | 4 Hydroxynonenal | inhibit |
| 相關(guān)產(chǎn)品 | Sucrose | Daidzein | Guanidine hydrochloride | Fumaric acid | Ferulic Acid | Vanillin | Formamide | Glycerol | Thymidine | Naringin | 3-Indoleacetic acid | Oleic acid |
| 相關(guān)庫(kù) | 抗癌天然產(chǎn)物庫(kù) | 經(jīng)典已知活性庫(kù) | 抗癌細(xì)胞代謝庫(kù) | 天然產(chǎn)物庫(kù) | 抑制劑庫(kù) | 高通量篩選天然產(chǎn)物庫(kù) | 已知活性化合物庫(kù) | 腸道微生物代謝化合物庫(kù) | 抗癌化合物庫(kù) | 抗癌活性化合物庫(kù) |
Company Profile Introduction
TargetMol Chemicals Inc. is headquartered in Boston, MA, and specializes in products and services that serve the research needs of chemical and biological scientists worldwide. With a client base in 40+ countries, TargetMol has evolved into one of the biggest global research suppliers for compound libraries and small molecule compounds.
170+ Compound Libraries， 10000+ Noval Small Molecucles，16000+ Nature Compounds
TargetMol diligently updates and offers over 170 types of compound libraries and a wide range of high-quality research chemicals, including inhibitors, activators, natural products, peptides, antibodies , and novel life-science kits for laboratory and scientific use. In addition, our lab allows us to conduct CADD (computer-aided drug design) and chemical synthesis to meet the customization needs of our clients.
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