4'-bromo-Resveratrol NEW
| Price | $68 | $109 | $228 |
| Package | 5mg | 10mg | 25mg |
| Min. Order: | |
| Supply Ability: | 10g |
| Update Time: | 2025-05-26 |
Product Details
| Product Name: 4'-bromo-Resveratrol | CAS No.: 1224713-90-9 |
| Purity: 99.4% | Supply Ability: 10g |
| Release date: 2025/05/26 |
Product Introduction
Bioactivity
| Name | 4'-bromo-Resveratrol |
| Description | 4'-bromo-Resveratrolis a potent inhibitor of the deacetylases sirtuin 1 (SIRT1) and 3 (SIRT3) |
| In vitro | 4'-BR treatment of melanoma cells resulted in (a) decrease in proliferation and clonogenic survival;?(b) induction of apoptosis accompanied by a decrease in procaspase-3, procaspase-8, and increase in the cleavage of caspase-3 and poly (ADP-ribose) polymerase (PARP);?(c) marked downregulation of proliferating cell nuclear antigen (PCNA);?and (d) inhibition of melanoma cell migration.?Further, 4'-BR caused a G0/G1 phase arrest of melanoma cells that was accompanied by an increase in WAF-1/P21 and decrease in Cyclin D1/Cyclin-dependent kinase 6 protein levels.?4'-BR causes a decrease in lactate production, glucose uptake, and NAD+ /NADH ratio.?These responses were accompanied by downregulation in lactate dehydrogenase A and glucose transporter 1 in melanoma cells.[1] |
| Storage | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice. |
| Solubility Information | DMSO : 30 mg/mL (103.04 mM), Sonication is recommended. |
| Keywords | Sirtuin-3 | Sirtuin-1 | Sirtuin | SIRT3 | SIRT1 | mitochondrial metabolic reprogramming | melanoma cell growth | Inhibitor | inhibit | cell cycle | Apoptosis | antiproliferative | 4'-bromo-Resveratrol | 4'bromoResveratrol | 4′‐BR | 4' bromo Resveratrol |
| Inhibitors Related | JGB1741 | Sirtinol | Selisistat | Dihydrocoumarin | Nicotinamide riboside chloride | Resveratrol | SRT 2104 | Nicotinamide riboside | MC3482 | Fisetin | 3-TYP | Nicotinamide |
| Related Compound Libraries | Apoptosis Compound Library | DNA Damage & Repair Compound Library | Histone Modification Compound Library | Bioactive Compound Library | Epigenetics Compound Library | Glutamine Metabolism Compound Library | Inhibitor Library | NO PAINS Compound Library | Mitochondria-Targeted Compound Library | Anti-Aging Compound Library | Bioactive Compounds Library Max | Anti-Cancer Compound Library |
Company Profile Introduction
Target Molecule Corp. (TargetMol) is a global high-tech enterprise, headquartered in Boston, MA, specializing in chemical and biological research product and service to meet the research needs of global customers.
TargetMol has evolved into one of the biggest global compound library and small molecule suppliers and a customer based on 40+ countries. TargetMol offers over 80 types of compound libraries and a wide range of high-quality research chemicals including inhibitors, activator, natural compounds, peptides, inhibitory antibodies, and novel life-science kits, for laboratory and scientific use. Besides, virtual screening service is also available for customers who would like to conduct the computer-aided drug discovery.
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United States- Since: 2011-01-07
- Address: 36 Washington Street, Wellesley Hill, MA
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