4-Aminohippuric Acid NEW
| Price | $35 | $47 |
| Package | 50mg | 100mg |
| Min. Order: | |
| Supply Ability: | 10g |
| Update Time: | 2024-11-19 |
Product Details
| Product Name: 4-Aminohippuric Acid | CAS No.: 61-78-9 |
| Purity: 98.23% | Supply Ability: 10g |
| Release date: 2024/11/19 |
Product Introduction
Bioactivity
| Name | 4-Aminohippuric Acid |
| Description | 4-Aminohippuric Acid is the glycine amide of 4-aminobenzoic acid. Its sodium salt is used as a diagnostic aid to measure effective renal plasma flow (ERPF) and excretory capacity. |
| In vitro | In normal individuals, the renal extraction ratio of 4-Aminohippuric acid is approximately 0.92. After extraction, the majority of 4-Aminohippuric acid is actively secreted by the proximal tubules and completely excreted by the kidneys. The clearance of 4-Aminohippuric acid is utilized to measure renal plasma flow and to assess the secretory mechanisms or transport limits of renal tubules. The kinetics of 4-Aminohippuric acid uptake by cortical tubular cells have been measured using the stopped-flow microperfusion technique in rat kidneys. In a rat model of renal failure, intravenous injection of 3.0 mg/kg Uranyl nitrate significantly reduced the CLPAH to 0.89 mL/min/kg, compared to 29.30 mL/min/kg in normal rats. Rats with chronic kidney failure exhibited altered pharmacokinetics, showing decreased renal excretion of 4-Aminohippuric acid. Compared to Sham rats, those with chronic kidney failure demonstrated a weakened load of excretion, filtration, and secretion of 4-Aminohippuric acid, with about a 40% reduction in the expression of OAT1 in the homogenate and membrane. Hence, measuring the renal clearance of 4-Aminohippuric acid typically reflects the kidney's capacity for organic anion transport. |
| In vivo | At a concentration of 10 mmol/L, 4-Aminohippuric acid was transported across membranes of HEK293 cells expressing MRP2 with a rate of 21.9 pmol/mg protein/min. The kinetic parameters for 4-Aminohippuric acid transport included a Km value of 880 mM and a Vmax value of 2.3 nmol/mg protein/min, indicating facilitated transport through organic anion transporters expressed in epithelial cells. Additionally, 4-Aminohippuric acid uptake by HEK293 cells, mediated by overexpressed and transfected NPT1, exhibited saturable kinetics in line with Michaelis-Menten dynamics, having a Km close to 2.66 mM and a Vmax of 940 pmol/mg protein/30s. This compound is also transported by transporters other than OAT, including NPT1 and MRP2. |
| Storage | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice. |
| Solubility Information | DMSO : 50 mg/mL (257.48 mM), Sonication is recommended. Ethanol : 2 mg/mL (10.29 mM) H2O : 3 mg/mL (15.44 mM) |
| Keywords | Inhibitor | Endogenous Metabolite | inhibit | 4Aminohippuric Acid | 4 Aminohippuric Acid | 4-Aminohippuric Acid | 4-Aminohippuric acid |
| Related Compound Libraries | Bioactive Compound Library | Natural Product Library | Natural Product Library for HTS | Human Endogenous Metabolite Library | Bioactive Compounds Library Max | Gut Microbial Metabolite Library |
Company Profile Introduction
Target Molecule Corp. (TargetMol) is a global high-tech enterprise, headquartered in Boston, MA, specializing in chemical and biological research product and service to meet the research needs of global customers.
TargetMol has evolved into one of the biggest global compound library and small molecule suppliers and a customer based on 40+ countries. TargetMol offers over 80 types of compound libraries and a wide range of high-quality research chemicals including inhibitors, activator, natural compounds, peptides, inhibitory antibodies, and novel life-science kits, for laboratory and scientific use. Besides, virtual screening service is also available for customers who would like to conduct the computer-aided drug discovery.
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