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Postion:Product Catalog >Chemical Reagents>Organic reagents>Aromatic ketones>4-Amino-3,5-dichloroacetophenone
4-Amino-3,5-dichloroacetophenone
  • 4-Amino-3,5-dichloroacetophenone
  • 4-Amino-3,5-dichloroacetophenone
  • 4-Amino-3,5-dichloroacetophenone
  • 4-Amino-3,5-dichloroacetophenone
  • 4-Amino-3,5-dichloroacetophenone

4-Amino-3,5-dichloroacetophenone NEW

Price Get Latest Price
Package 1KG 5KG 25KG
Min. Order: 1KG
Supply Ability: 20 T each week
Update Time: 2023-08-13

Product Details

Product Name: 4-Amino-3,5-dichloroacetophenone CAS No.: 37148-48-4
EC-No.: 253-368-1 Min. Order: 1KG
Purity: 98%~99% Supply Ability: 20 T each week
Release date: 2023/08/13

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Product Name:4-Amino-3,5-dichloroacetophenone
Synonyms:1-(4-Amino-3,5-dichlorophenyl)-ethanone, 3,5-Dichloro-4-aminoacetophenone;1-(4-Amino-3,5-dichloro-phenyl)-2-ethanone;5-AMINO-3,5-DICHLORO ACETOPHENONE;4''-AMINO-3'',5''-DICHLOROACETOPHENONECLENBUTEROL;4-Amino-3,5-dichloroacetophenone,98%;4′-Amino-3′,5′-dichloroacetophenone,1-(4-Amino-3,5-dichlorophenyl)-ethanone, 3,5-Dichloro-4-aminoacetophenone;3,5-dichloro-p-aMino acetophenone;4-AMino-3,5-dichloroacetophenone, 98% 5GR
CAS:37148-48-4
MF:C8H7Cl2NO
MW:204.05
EINECS:253-368-1
Product Categories:Chemical Amines;Amines;Aromatic Acetophenones & Derivatives (substituted);(intermediate of leflunomide);Aromatics;37148-48-4
Mol File:37148-48-4.mol
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4-Amino-3,5-dichloroacetophenone Chemical Properties
Melting point 162-166 °C(lit.)
Boiling point 351.5±42.0 °C(Predicted)
density 1.2748 (rough estimate)
refractive index 1.5500 (estimate)
storage temp. Keep in dark place,Inert atmosphere,Room temperature
solubility DMSO (Slightly), Methanol (Slightly)
form Solid
pka-1.72±0.10(Predicted)
color Light Tan to Brown
InChIInChI=1S/C8H7Cl2NO/c1-4(12)5-2-6(9)8(11)7(10)3-5/h2-3H,11H2,1H3
InChIKeyJLPKZJDZXIKSCP-UHFFFAOYSA-N
SMILESC(=O)(C1=CC(Cl)=C(N)C(Cl)=C1)C
CAS DataBase Reference37148-48-4(CAS DataBase Reference)

Safety Information
Hazard Codes Xi
Risk Statements 36/37/38
Safety Statements 26-36-37/39
WGK Germany 3
HS Code 29223990

4-Amino-3,5-dichloroacetophenone Usage And Synthesis
Description 4-Amino-3,5-dichloroacetophenone is an intermediate in the synthesis of the antitussive and antiasthmatic drug gramtin.
Storage4-Amino-3,5-dichloroacetophenone should be stored in a cool, dry place in a small, well filled, well-closed container, protected from light. When a partially filled container is used, the air should be replaced by nitrogen or another inert gas.
4-Amino-3,5-dichloroacetophenone oxidizes on exposure to air, resulting in an increase in the peroxide value.
Chemical Properties4-Amino-3,5-dichloroacetophenone is a white to light yellow crystal powder. Insoluble in cold water, slightly soluble in hot water.
Uses4-Amino-3,5-dichloroacetophenone is used to synthesize the drug Clenbuterol. Clenbuterol is a steroid-like chemical that was initially developed to treat asthma in horses, working by relaxing the airways in the animals'lungs.
Preparation4-Amino-3,5-dichloroacetophenone was synthesized by chlorination of 4-aminoacetophenone. Add 4-aminoacetophenone and acetic acid (80%) into the reaction pot, stir and dissolve, quickly add chlorine-containing glacial acetic acid solution, the temperature of the addition is 5°C. After the addition is completed, immediately put into ice water to precipitate, filter, and wash with water to obtain the crude product. Recrystallize with ethanol to obtain the finished product of 4-Amino-3,5-dichloroacetophenone.
Application4-Amino-3,5-dichloroacetophenone is a compound useful in organic synthesis.

4-Amino-3,5-dichloroacetophenone Preparation Products And Raw materials
Raw materialsAcetic acid-->4-Aminoacetophenone-->Acetic anhydride-->Chlorine-->Acetyl chloride-->2,6-Dichloroaniline-->2,4,6-Trichloroaniline
Preparation Products4-AMINO-ALPHA-TERT-BUTYLAMINE-3,5-DICHLOROACETOPHENONE-->4-Amino-3,5-dichloro-alpha-bromoacetophenone-->1-(4-AMINO-3-CHLORO-PHENYL)-ETHANONE-->Clenbuterol hydrochloride-->3,4,5-TRICHLORO-BENZOICACID-->3',5'-Dichloroacetophenone


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