4-(2-Aminoethyl)benzenesulfonylfluoride hydrochloride NEW
Price | Get Latest Price | ||
Package | 1KG | 5KG | 25KG |
Min. Order: | 1KG |
Supply Ability: | 20 T each week |
Update Time: | 2023-08-13 |
Product Details
Product Name: 4-(2-Aminoethyl)benzenesulfonylfluoride hydrochloride | CAS No.: 30827-99-7 |
EC-No.: 608-547-2 | Min. Order: 1KG |
Purity: 98%~99% | Supply Ability: 20 T each week |
Release date: 2023/08/13 |
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Product Name: | 4-(2-Aminoethyl)benzenesulfonylfluoride hydrochloride |
Synonyms: | 4-(Fluorosulphonyl)phenethylamine hydrochloride, 2-[4-(Fluorosulphonyl)phenyl]ethylamine hydrochloride, AEBSF;Benzenesulfonyl fluoride, 4-(2-aMinoethyl)-, hydrochloride (1:1);4-(2-AMinoethyl)benzenesulfonyl fluoride hydrochlorid;4-(2-Aminoethyl)-benzenesulfonyl fluoride hydrochloride (1:1);BROMOPHENOL BLUE NA SALT PROTEOMICS GR;AEBSF HCI;AEBSF;AEBSF HCL |
CAS: | 30827-99-7 |
MF: | C8H11ClFNO2S |
MW: | 239.69 |
EINECS: | 608-547-2 |
Product Categories: | ProteaseInhibitors;inhibitor;Inhibitors |
Mol File: | 30827-99-7.mol |
4-(2-Aminoethyl)benzenesulfonylfluoride hydrochloride Chemical Properties |
Melting point | 175-177 °C |
storage temp. | 2-8°C |
solubility | H2O: soluble50mg/mL (stable for up to six months if stored refrigerated at a pH of less than 7. If a pH of greater than 7 is required, pH adjustment should be made just prior to use.) |
form | Powder |
color | White |
PH | pH3.0~5.0 (10g/L, 25℃) |
Water Solubility | 10 g/L (20 oC) |
Sensitive | Moisture Sensitive |
BRN | 7604627 |
Stability: | Stable for 1 year from date of purchase as supplied. Solutions at pH <7 are stable for up to 6 months if stored in the refrigerator |
InChIKey | WRDABNWSWOHGMS-UHFFFAOYSA-N |
CAS DataBase Reference | 30827-99-7(CAS DataBase Reference) |
Safety Information |
Hazard Codes | C,Xi |
Risk Statements | 34-36/37/38 |
Safety Statements | 45-36/37/39-26-36 |
RIDADR | UN 3261 |
WGK Germany | 3 |
Hazard Note | Corrosive |
HazardClass | 8 |
PackingGroup | II |
HS Code | 29214990 |
4-(2-Aminoethyl)benzenesulfonylfluoride hydrochloride Usage And Synthesis |
Description | AEBSF is a water soluble, irreversible, broad spectrum inhibitor of serine proteases, including trypsin, chymotrypsin, plasmin, thrombin, and kallikreins. AEBSF can also prevent the activation of the ROS generator, NADPH oxidase. At 10-50 μg, AEBSF can attenuate airway inflammation in a mouse model of airway allergy. AEBSF maintains stability in slightly acidic aqueous solutions and serves as a nontoxic alternative to the organophosphate inhibitors, PMSF and DFP. |
Chemical Properties | white powder |
Uses | AEBSF is extensively used in studies aiming to describe cholesterol regulatory genes due to its potent ability to inhibit Site-1-protease (S1P). This serine protease, located in the Golgi apparatus, is responsible for activating the sterol regulatory element-binding proteins. By selectively inhibiting S1P, AEBSF can be used to characterize the downstream result of SREBP inhibition and its influence on cholesterol regulation. |
Uses | Recommended concentrations for use are 0.1-1 mM. |
General Description | Pefabloc? SC is a trypsin inhibitor, which can be used in the synthesis of its arginine-like analogue, 4-(2-guanidinoethyl)benzenesulfonyl fluoride. |
Biochem/physiol Actions | Irreversible serine protease inhibitor. Inhibition constants are similar to those of PMSF and DFP. AEBSF has been shown to inhibit trypsin, chymotrypsin, plasmin kallikrein and thrombin. As an alternative to PMSF and DFP, AEBSF offers lower toxicity, improved solubility in water and improved stability in aqueous solutions. AEBSF has been used in cell culture in concentrations of up to 0.25?mM. |
storage | Store at -20°C |
References | 1) Powers?et al. (2002),?Irreversible inhibitors of serine, cysteine and threonine proteases; Chem. Rev.,?102?4639 2) Diatchuk?et al.?(1997),?Inhibition of NADPH oxidase activation by 4-(2-aminoethyl)-benzenesulfonyl fluoride and related compounds; J. Biol. Chem.,?272?13292 |
Company Profile Introduction
Shandong Huisheng Import & Export Co., Ltd. is located in Jinan city, Shandong Province, is a collection of domestic trade, international trade in one of the diversified services company. Our goal is to provide customers with high quality solutions and one-stop purchasing experience. At present, the company business scope involves five areas: Organic chemical raw materials, inorganic chemical raw materials, fine chemical raw materials, dangerous chemicals and green environmental protection chemical technology project promotion, and we has also established good relations of cooperation with several well-known enterprises and won the strong support of extensive trust from the new and old customers.
Products are widely used in automobile, household appliances, office supplies, mobile phone accessories, routers, food, medical and other fields. At present, our business covers 30 countries, and our customers mainly come from Australia, New Zealand, Canada, Germany, France, Poland, South Korea, Russia, Bangladesh, Vietnam, Kazakhstan, India, Ghana, Nigeria, South Africa, Egypt and other more than 30 countries.
The company has a sound quality management system and advanced professional equipment, with a positive attitude to meet the changing needs of customers. We take "quality products, quality service, competitive price, timely delivery" as the purpose, looking forward to greater cooperation with overseas customers on the basis of mutual benefit.
Our company provides a wide range of products to meet your various needs. Since its inception, the company has always adhered to the "quality first, customer first, reputation first" business policy, wholeheartedly meet the potential needs of our customers. Under the irresistible situation of economic globalization, our company is willing to cooperate sincerely with enterprises around the world to achieve a win-win situation.
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