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Postion:Product Catalog >API>Synthetic Anti-infective Drugs>Antifungal Drugs>Ketoconazole
Ketoconazole
  • Ketoconazole

Ketoconazole

Price $10
Package 1KG
Min. Order: 10G
Supply Ability: 10MT
Update Time: 2019-01-15

Product Details

Product Name: Ketoconazole CAS No.: 65277-42-1
EC-No.: 265-667-4 Min. Order: 10G
Purity: 99% Supply Ability: 10MT
Release date: 2019/01/15
MF: C26H28Cl2N4O4 Character: White crystalline powder
Usage: Imidazole antifungal agents

Quick Detail:

Synonyms: ketoderm; nizoral

CAS: 65277-42-1

EINECS: 265-667-4

MF: C26H28Cl2N4O4

MW: 531.43

Assay: 99% min.

Standard: EP/BP/USP

Packing: 25Kg/cardboard drum

 

Character: White crystalline powder. Melting point 146 ºC, insoluble in water.

Usage: Imidazole antifungal agents. For the treatment of conditions such as athlete's foot and excessive dandruff.

 

Ketoconazole is an imidazole fungicidal agent with a very broad spectrum of activity against many fungal species that is used for treatment of superficial and systemic fungal infections. Ketoconazole is a well documented cause of clinically apparent acute drug induced liver injury and is no longer recommended as a first line antifungal agent.

 

Inhibits cytochrome P-450 dependent steps in the biosynthesis of steroid hormones in vivo. Antimetastatic and antineoplastic activity. Orally active 5-lipoxygenase and thromboxane synthase inhibitor

 

Clinical application for treatment of hand eczema, athlete's foot, skin, ringworm, tinea, jock itch, thrush, tinea versicolor and cutaneous candidiasis.

 

COA:

Items

Standard

Results

Characters

White or almost white powder

Qualified

Identification

Meets the requirements

Qualified

Melting range

148°C ~ 152°C

148.0~ 150.0°C

Appearance of solution

Meets the requirements

Qualified

Organic volatile impurities

Meets USP30

Qualified

Specific rotation

-1° ~ +1°

 

-0.10° ~ +0.10°

 

Chromatographic purity

Meets the requirements

Qualified

Heavy metals

≤0.002%

Qualified

Loss on drying

≤0.5%

0.1%

Residue on ignition

≤0.1%

0.05%

Assay

98.0% ~ 102.0%

99.69%

 

99.0%~101.0%

 

CONCLUSION:

USP30

 

Description:

Ketoconazole is a broad-spectrum antifungal imidazole with commercially available product being under the trade name of Jindakening, Meikangling and keNing. It interferes with the activity of fungal cytochrome P-450 with a high selectivity, thus inhibiting the biosynthesis of ergosterol in fungal cell membrane.

 

Ketoconazole is effective in treating both shallow, deep fungal infections and can inhibit both fungal growth and the transition from spores to mycelium to prevent the further infection. It has antifungal effect on Candida genus, Fonsecaea, Coccidioides, Histoplasma, Sporothrix spp and Trichophyton. Clinically, it is suitable for the treatment of ringworm, athlete's foot, and skin ringworm, tinea, jock itch, and thrush, tinea versicolor as well as cutaneous candidiasis.

 

Application:

Ketoconazole lotion, as a skin external use, is mainly used for clinical treatment and prevention of various kinds of infections caused by Malassezia such as tinea versicolor, seborrheic dermatitis and scalp pityriasis (dandruff), and can quickly alleviate the desquamation and itching caused by seborrheic dermatitis and scalp pityriasis.

Advantages:
 
Hubei XinRunde Chemical Co., Ltd is a renowned pharmaceutical manufacturer. We can offer high quality products at competitive price in quick delivery with 100% custom pass guaranteed. Never stop striving to offer our best service is our philosophy. We have Flexible and Untraceable payment terms. As a leading manufacture, our products have been exported to Germany, Norway, Poland, Finland, Spain, UK, France, Russia, USA, Brazil, Mexico, Australia, Japan, Korea, Thailand, Indonesia, Uruguay and many other countries.


1. Quality.Every batch of steroid powders have tobetested by our QC(quality control) before they are allowed to sell.


2. Delivery We have stock, so we can delivery quickly at the very day when receive the payment. Within 24 hours after receiving the payment Lead time 4 or 7 days.


3. Discreet package Safelyand Professionally Disguised Package Guaranteed. For your safety and to insure delivery all products will be packed in a discreet way to prevent any suspicions, no steroids related name will appear on the parcels. high successful delivery rate.


4. Warm after-sale service Any of your question would be solved for the first as soon as possible.

 

Company Profile Introduction

Hubei XinRunde Chemical Co., Ltd covers an area of 95 acres, the proposed construction of the plant will be GMP standards, the factory environment clean and tidy, rational layout, with large and medium-sized production workshop and repocessed shop. It is equipped with advanced equipment quality inspection and research center. Those products of both quality and technical content have reached the domestic advanced level. Products sell well all over the country and exported to Europe and the United States and Southeast Asia,and so on.

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