3-CHLORO-5-HYDROXY-BENZOIC ACID NEW

Price	$3	$0.2
Package	1KG	1000KG

Min. Order:	1KG
Supply Ability:	g-kg-tons, free sample is available
Update Time:	2024-03-26

Product Details

Product Name: 3-CHLORO-5-HYDROXY-BENZOIC ACID	CAS No.: 53984-36-4
Min. Order: 1KG	Purity: 98%
Supply Ability: g-kg-tons, free sample is available	Release date: 2024/03/26
Lead time: In stock, ready for shipment	Packaging: bag/bottle/drum/IBC
Delivery: By express, by air, by sea	Origin: Manufacturer, advantage product
COA, MSDS: Available, contact us for details	Name: Tina

1. Materials information

Names

Name	3-Chloro-5-hydroxybenzoic acid
Synonym	More Synonyms

Description	3-Chloro-5-hydroxybenzoic acid is a potent, orally active and selective lactate receptor GPR81 agonist, with an EC50 of 16 μM for human GPR81. 3-Chloro-5-hydroxybenzoic acid exhibits favorable in vivo effects on lipolysis in a mouse model of obesity[1].
Related Catalog	Signaling Pathways >> Others >> Others Research Areas >> Metabolic Disease
In Vitro	3-Chloro-5-hydroxybenzoic acid shows potency against human (EC50=16 μM), monkey (EC50=17 μM), dog (EC50=67 μM), rat (EC50=7 μM), mouse (EC50=22 μM), and hamster GPR81 (EC50=27 μM)[1].
In Vivo	3-Chloro-5-hydroxybenzoic acid (30, 100, and 300 mg/kg; PO in overnight fasted C57Bl6/J mice fed high fat chow for 10 weeks) shows significant reductions in free fatty acids at all doses tested, resulting in a minimum efficacious dose of 30 mg/kg[1]. Pharmacokinetic Parameters of 3-Chloro-5-hydroxybenzoic acid in Mice[1]. dose (mg/kg) tmax (h) AUCinf (h ng/mL) Cmax (ng/mL) Cmax (μM) t1/2 (h) 30 0.5 9356 11689.50 67.2 1.47 100 0.5 51312 55252.80 341.9 1.10 Animal Model: C57Bl6/J mice (DIO mice)[1] Dosage: 30, 100, and 300 mg/kg Administration: PO in overnight fasted C57Bl6/J mice fed high fat chow for 10 weeks Result: Significant reductions in nonesterified free fatty acid cholesterol (NEFAc) at all doses tested.
References	[1]. Dvorak CA, et al. Identification of Hydroxybenzoic Acids as Selective Lactate Receptor (GPR81) Agonists with Antilipolytic Effects. ACS Med Chem Lett. 2012;3(8):637-639. Published 2012 Jun 11.

Density	1.5±0.1 g/cm3
Boiling Point	364.8±27.0 °C at 760 mmHg
Molecular Formula	C₇H₅ClO₃
Molecular Weight	172.566
Flash Point	174.4±23.7 °C
Exact Mass	171.992722
PSA	57.53000
LogP	2.83
Vapour Pressure	0.0±0.9 mmHg at 25°C
Index of Refraction	1.630

3-Chloro-5-hydroxybenzoic acid MSDS(Chinese)

Symbol	GHS05, GHS07
Signal Word	Danger
Hazard Statements	H302-H315-H318-H335
Precautionary Statements	P261-P280-P305 + P351 + P338
RIDADR	NONH for all modes of transport
HS Code	2918290000

3-Chloro-5-meth...

CAS#:82477-67-6

~80%

3-Chloro-5-hydr...

CAS#:53984-36-4

Literature: ASTRAZENECA AB Patent: WO2003/101956 A1, 2003 ; Location in patent: Page 55; 56 ; WO 03/101956 A1

Precursor 1
CAS#:82477-67-6 3-Chloro-5-meth...
DownStream 1
CAS#:98406-04-3 Methyl 3-chloro...

HS Code	2918290000
Summary	HS: 2918290000 other carboxylic acids with phenol function but without other oxygen function, their anhydrides, halides, peroxides, peroxyacids and their derivatives Tax rebate rate:9.0% Supervision conditions:AB(certificate of inspection for goods inward,certificate of inspection for goods outward) VAT:17.0% MFN tariff:6.5% General tariff:30.0%

2. Packaging of materials

For powders: normal is 25kgs/Drum or bag, or larger/smaller package as request.
For liquids: normal 25kgs/drum, 180-300kgs/bucket, or IBC, determined by the nature of the product.

Or smaller package 1kg/bottle, 10kgs/bottle as request.

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3. Shipping & Delivery

By Express

Provide door to door service

Suitable for goods under 50kg

Delivery: 3-7 days

Cost: low cost

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By Air

Provide airport to airport service

Suitable for goods over 50kg

Delivery: 3-14 days

Cost: high cost

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By Sea

Provide seaport to seaport service

Suitable for goods over 100kg

Delivery: 2-45 days

Cost: low cost

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4. Contact information

For more details, pls contact us freely.

Email address: Tina@fdachem.com

Mob: 86 15225627621

WhatsApp/Skype/Wechat/LINE: 86 15225627621

Company Profile Introduction

Henan Fengda Chemical Co., Ltd. is located in the High-tech Development Zone of Henan Province. Specializing in the production and sales of various fine chemical products required for industrial production, including chemical raw materials, organic raw materials, petrochemicals, chemical reagents, solvents, catalysts, and additives, etc.

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