3-Bromo-7-nitroindazole NEW
| Price | $44 | $77 | $127 |
| Package | 25mg | 50mg | 100mg |
| Min. Order: | |
| Supply Ability: | 10g |
| Update Time: | 2024-11-11 |
Product Details
| Product Name: 3-Bromo-7-nitroindazole | CAS No.: 74209-34-0 |
| Purity: 97.44% | Supply Ability: 10g |
| Release date: 2024/11/11 |
Product Introduction
Bioactivity
| 名稱 | 3-Bromo-7-nitroindazole |
| 描述 | 3-Bromo-7-nitroindazole is a specific neuronal nitric oxide synthase (nNOS) inhibitor that affects the synthesis of the intercellular messenger NO throughout the brain and body. |
| 體內(nèi)活性 | Male rats received either 3-Bromo-7-nitroindazole (20mg/kg/day) or saline via intraperitoneal injection for 5days. Daily administration of the specific neuronal nitric oxide synthase (nNOS) inhibitor, 3-Bromo-7-nitroindazole impaired the acquisition of the Morris water maze (MWM) paradigm task. 3-Bromo-7-nitroindazole also impaired the probe trial. The MWM training was associated with a significant increase in the brain-derived neurotrophic factor (BDNF) mRNA expression in the hippocampus. BDNF mRNA expression in the hippocampus did not change after 3-Bromo-7-nitroindazole treatment. L-arginine significantly reversed behavioural parameters, and the effect of 3-Bromo-7-nitroindazole was found to be NO-dependent. There were no differences in locomotor activity and blood pressure in 3-Bromo-7-nitroindazole treated rats[1]. |
| 存儲(chǔ)條件 | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice. |
| 溶解度 | DMSO : 100 mg/mL (413.17 mM) |
| 關(guān)鍵字 | 3Bromo7nitroindazole | inhibit | NO Synthase | 3-Bromo-7-nitroindazole | Nitric oxide synthases | Inhibitor | NOS | 3 Bromo 7 nitroindazole |
| 相關(guān)產(chǎn)品 | L-NAME hydrochloride | Dexamethasone acetate | Diallyl disulfide |
| 相關(guān)庫 | 經(jīng)典已知活性庫 | 抑制劑庫 | 神經(jīng)保護(hù)化合物庫 | 已知活性化合物庫 |
Company Profile Introduction
Target Molecule Corp. (TargetMol) is a global high-tech enterprise, headquartered in Boston, MA, specializing in chemical and biological research product and service to meet the research needs of global customers.
TargetMol has evolved into one of the biggest global compound library and small molecule suppliers and a customer based on 40+ countries. TargetMol offers over 80 types of compound libraries and a wide range of high-quality research chemicals including inhibitors, activator, natural compounds, peptides, inhibitory antibodies, and novel life-science kits, for laboratory and scientific use. Besides, virtual screening service is also available for customers who would like to conduct the computer-aided drug discovery.
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United States- Since: 2011-01-07
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