3α-Aminocholestane NEW
| Price | $49 |
| Package | 1mg |
| Min. Order: | |
| Supply Ability: | 10g |
| Update Time: | 2024-11-19 |
Product Details
| Product Name: 3α-Aminocholestane | CAS No.: 2206-20-4 |
| Purity: ≥98.0% | Supply Ability: 10g |
| Release date: 2024/11/19 |
Product Introduction
Bioactivity
| Name | 3α-Aminocholestane |
| Description | 3α-Aminocholestane (5α-Cholestan-3α-amine) is a potent inhibitor of inositol-5'-phosphatase 1 (SHIP1) containing the SH2 structural domain (IC50 : 2.5 μM) for research and immune-related diseases. |
| In vitro | MM cells were treated with increasing concentrations of 3α-Aminocholestane (3AC) for 48 hours. After cell lysis, proteins were separated by SDS-PAGE and probed with antibodies against SHIP1, SHIP2, and PTEN. The results indicate that treatment with3α-Aminocholestane (3AC)leads to proteasomal degradation of the SHIP1 protein[1]. |
| In vivo | NOD/SCID/γcIL2R (NSG) mutant mice were inoculated with 1 × 10^7 MM cells (OPM2) via intraperitoneal injection. Six hours later, the mice received the first injection of 3α-Aminocholestane (3AC), followed by daily injections for the next 7 days, and subsequently, injections every two weeks for the following 15 weeks. The results indicate that treatment with 3α-Aminocholestane (3AC) inhibits the growth of MM cells in vivo.[1]. |
| Storage | store at low temperature | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice. |
| Solubility Information | DMSO : <0.1 mg/mL Ethanol : 30 mg/mL (77.38 mM), Sonication is recommended. |
| Keywords | 3alpha-Aminocholestane | 3α Aminocholestane | 3-A-Aminocholestane | 3AC | 3αAminocholestane | 3α-Aminocholestane | 3a-Aminocholestane |
| Inhibitors Related | PTP1B-IN-22 | Disodium monofluorophosphate | β-Glycerophosphate disodium salt pentahydrate | Tartaric acid disodium dihydrate | Cyclosporine | Stearic acid | Cis-5-Norbornene-exo-2,3-dicarboxylic Anhydride | L-Ascorbic acid 2-phosphate magnesium | Cyclosporin A | Trimyristin |
Company Profile Introduction
Target Molecule Corp. (TargetMol) is a global high-tech enterprise, headquartered in Boston, MA, specializing in chemical and biological research product and service to meet the research needs of global customers.
TargetMol has evolved into one of the biggest global compound library and small molecule suppliers and a customer based on 40+ countries. TargetMol offers over 80 types of compound libraries and a wide range of high-quality research chemicals including inhibitors, activator, natural compounds, peptides, inhibitory antibodies, and novel life-science kits, for laboratory and scientific use. Besides, virtual screening service is also available for customers who would like to conduct the computer-aided drug discovery.
You may like
Recommended supplier
| Product name | Price | Suppliers | Update time | |
|---|---|---|---|---|
| $0.00/1g |
VIP4Y
|
WUHAN FORTUNA CHEMICAL CO., LTD
|
2021-08-25 | |
| $372.00/10mg |
VIP5Y
|
TargetMol Chemicals Inc.
|
2024-10-23 | |
| $6480.00/1KG |
VIP4Y
|
Baoji Guokang Bio-Technology Co., Ltd.
|
2021-06-07 |
United States- Since: 2011-01-07
- Address: 36?Washington?Street, Wellesley?Hills
INQUIRY