2-Ketoglutaric acid Sodium NEW
| Price | $29 |
| Package | 1mL |
| Min. Order: | |
| Supply Ability: | 10g |
| Update Time: | 2025-06-18 |
Product Details
| Product Name: 2-Ketoglutaric acid Sodium | CAS No.: 22202-68-2 |
| Purity: 100% | Supply Ability: 10g |
| Release date: 2025/06/18 |
Product Introduction
Bioactivity
| Name | 2-Ketoglutaric acid Sodium |
| Description | 2-Ketoglutaric acid Sodium (AKG) is a key molecule in the TCA cycle. It can be produced from glutamate by oxidative deamination via glutamate dehydrogenase and as a product of pyridoxal phosphate-dependent transamination reactions (mediated by branched-chain amino acid transaminases) in which glutamate is a common amino donor. |
| In vitro | 2-Ketoglutaric acid Sodium is a nitrogen scavenger and a source of glutamate and glutamine that stimulates protein synthesis and inhibits protein degradation in muscles. In particular, 2-Ketoglutaric acid Sodium can decrease protein catabolism and increase protein synthesis to enhance bone tissue formation in skeletal muscles. It has recently been shown that 2-Ketoglutaric acid Sodium can extend the lifespan of adult C. elegans by inhibiting ATP synthase and TOR. In combination with molecular oxygen, alpha-ketoglutarate is required for the hydroxylation of proline to hydroxyproline in the production of type I collagen. A recent study has shown that alpha-ketoglutarate promotes TH1 differentiation along with the depletion of glutamine thereby favouring Treg (regulatory T-cell) differentiation. |
| Storage | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice. |
| Solubility Information | DMSO : 50 mg/mL (297.48 mM), Sonication is recommended. |
| Keywords | α-Ketoglutaric acid sodium | Tyrosinase | TCA | skeleton | precursor | intermediate | Inhibitor | inhibit | EndogenousMetabolite | Endogenous Metabolite | carbon | alpha-Ketoglutaric acid sodium | Alpha-Ketoglutaric acid | a-Ketoglutaric acid sodium | 2-Ketoglutaric acid Sodium | 2Ketoglutaric acid Sodium | 2-Ketoglutaric acid | 2 Ketoglutaric acid Sodium |
| Inhibitors Related | Sucrose | Acetaminophen | Daidzein | Guanidine hydrochloride | Fumaric acid | Ferulic Acid | L-Methionine | Formamide | Glycerol | Thymidine | Naringin | 3-Indoleacetic acid |
| Related Compound Libraries | Glutamine Metabolism Compound Library | Natural Product Library | RO5 Drug-like Natural Product Library | Human Endogenous Metabolite Library | Gut Microbial Metabolite Library | Human Metabolite Library |
Company Profile Introduction
Target Molecule Corp. (TargetMol) is a global high-tech enterprise, headquartered in Boston, MA, specializing in chemical and biological research product and service to meet the research needs of global customers.
TargetMol has evolved into one of the biggest global compound library and small molecule suppliers and a customer based on 40+ countries. TargetMol offers over 80 types of compound libraries and a wide range of high-quality research chemicals including inhibitors, activator, natural compounds, peptides, inhibitory antibodies, and novel life-science kits, for laboratory and scientific use. Besides, virtual screening service is also available for customers who would like to conduct the computer-aided drug discovery.
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United States- Since: 2011-01-07
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