2-Furoyl-LIGRLO-amide TFA NEW
| Price | Get Latest Price | |
| Package | 5mg | 50mg |
| Min. Order: | |
| Supply Ability: | 10g |
| Update Time: | 2024-11-19 |
Product Details
| Product Name: 2-Furoyl-LIGRLO-amide TFA | CAS No.: 2468029-34-5 |
| Supply Ability: 10g | Release date: 2024/11/19 |
Product Introduction
Bioactivity
| Name | 2-Furoyl-LIGRLO-amide TFA |
| Description | 2-Furoyl-LIGRLO-amide TFA is a potent, selective agonist of the proteinase-activated receptor 2 (PAR2), with a pD2 value of 7.0 [1] [2]. |
| In vitro | 2-Furoyl-LIGRLO-amide (2-Furoyl-LIGRLO-NH2) demonstrates equivalent efficacy and exhibits 10 to 25-fold greater potency than SLIGRLNH2 in elevating intracellular calcium levels in human and rat cells expressing PAR2, respectively [1]. In tissue, it surpasses SLIGRL-NH2 by 10 to 300 times in causing arterial vasodilation and hyperpolarization. Unlike trans-cinnamoyl-LIGRLO-NH2, it does not induce significant non-PAR2-mediated contraction in mouse femoral arteries [1]. |
| In vivo | When administered intradermally at the nape of the neck as a pre-injection at a dose of 10 μg, Furoyl-LIGRLO-amide TFA reduces scratching responses to 2-Furoyl-LIGRLO-amide in Trpv3 -/- mice, but not to histamine. In wild-type (WT) mice, however, the compound significantly decreases scratch behavior [3]. |
| Storage | Shipping with blue ice. |
Company Profile Introduction
TargetMol Chemicals Inc. is headquartered in Boston, MA, and specializes in products and services that serve the research needs of chemical and biological scientists worldwide. With a client base in 40+ countries, TargetMol has evolved into one of the biggest global research suppliers for compound libraries and small molecule compounds.
170+ Compound Libraries， 10000+ Noval Small Molecucles，16000+ Nature Compounds
TargetMol diligently updates and offers over 170 types of compound libraries and a wide range of high-quality research chemicals, including inhibitors, activators, natural products, peptides, antibodies , and novel life-science kits for laboratory and scientific use. In addition, our lab allows us to conduct CADD (computer-aided drug design) and chemical synthesis to meet the customization needs of our clients.
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