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Postion:Product Catalog >API>Hormones and the Endocrine System>Contraceptives>17α-Hydroxyprogesterone
17α-Hydroxyprogesterone
  • 17α-Hydroxyprogesterone
  • 17α-Hydroxyprogesterone

17α-Hydroxyprogesterone NEW

Price Get Latest Price
Package 1kg 25kg
Min. Order: 1kg
Supply Ability: 1000kg
Update Time: 2024-12-24

Product Details

Product Name: 17α-Hydroxyprogesterone CAS No.: 68-96-2
EC-No.: 200-699-4 Min. Order: 1kg
Purity: 99% Supply Ability: 1000kg
Release date: 2024/12/24

What is 17α-Hydroxyprogesterone?

17α-Hydroxyprogesterone (17-OHP) is a naturally occurring steroid hormone that is an intermediate in the biosynthesis of glucocorticoids, androgens, and estrogens. It is produced primarily in the adrenal glands and, to a lesser extent, in the ovaries and testes. 17α-Hydroxyprogesterone is a precursor to hormones like cortisol and testosterone.

Chemical Structure and Properties

  • Chemical Formula: C21H30O3

  • Molecular Weight: Approximately 330.46 g/mol

  • Structure: 17α-Hydroxyprogesterone has a steroid backbone with hydroxyl (-OH) group attached at the 17th carbon position and a keto group (=O) at the 3rd position. The 21-carbon structure is typical of many steroid hormones.

  • Appearance: Typically a white to off-white crystalline powder.

  • Solubility: Soluble in organic solvents like ethanol, methanol, and chloroform; sparingly soluble in water.

  • Stability: Stable under normal conditions, but it should be stored in a cool, dry place away from light to prevent degradation.

Biological Function

  • Glucocorticoid Synthesis: 17α-Hydroxyprogesterone is a key intermediate in the biosynthesis of cortisol, a major glucocorticoid produced by the adrenal glands. Cortisol plays a crucial role in regulating metabolism, immune response, and stress.

  • Androgen and Estrogen Synthesis: It also serves as a precursor in the production of androgens like testosterone and estrogens like estradiol, both of which are important for sexual development and reproductive function.

Clinical Relevance

1. Congenital Adrenal Hyperplasia (CAH)

  • Application: Elevated levels of 17α-Hydroxyprogesterone are used as a biomarker for diagnosing congenital adrenal hyperplasia (CAH), a genetic disorder affecting adrenal steroidogenesis.

  • Benefits: Measuring 17-OHP levels in newborn screening can help detect CAH early, allowing for timely treatment to manage symptoms and prevent complications such as salt-wasting crises.

2. Fertility and Reproductive Health

  • Application: 17α-Hydroxyprogesterone levels may be monitored in women undergoing fertility treatment, as abnormal levels can indicate issues with ovulation or adrenal function.

  • Benefits: Understanding 17-OHP levels can help guide treatment plans for conditions like polycystic ovary syndrome (PCOS) and other reproductive disorders.

3. Hormone Replacement Therapy

  • Application: It is sometimes used in hormone replacement therapy to help balance hormone levels in conditions where natural production is insufficient or disrupted.

  • Benefits: Helps restore normal physiological function by supplementing the body’s hormone levels.

Synthetic Derivatives

  • Pharmaceutical Use: Synthetic derivatives of 17α-Hydroxyprogesterone, such as 17α-Hydroxyprogesterone caproate, are used in clinical settings. For instance, 17α-Hydroxyprogesterone caproate is used to reduce the risk of preterm birth in pregnant women who have a history of spontaneous preterm delivery.

Safety and Handling

  • Toxicity: Generally, 17α-Hydroxyprogesterone is considered safe when used in clinical settings under medical supervision. However, it should not be handled without proper precautions, such as using gloves and avoiding inhalation or ingestion.

  • Environmental Impact: Disposal should be conducted in accordance with local regulations to prevent environmental contamination.

Summary

17α-Hydroxyprogesterone is a vital steroid hormone involved in the biosynthesis of glucocorticoids, androgens, and estrogens. It plays a crucial role in physiological processes such as stress response, metabolism, and reproductive function. Clinically, it is an important biomarker for diagnosing conditions like congenital adrenal hyperplasia and is also used in hormone replacement therapy.


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Company Profile Introduction

Wuhan Fortuna Chemical Co.,Ltd established in 2006, is a big integrative chemical enterprise being engaged in Pharmaceutical & its intermediates, Food/Feed additives, Fine chemicals in distributing the products of our own company and affiliated enterprises, are the members of Hubei E-commerce Chamber.

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