87530-30-1
中文名稱
4,7-二羥基-2-甲氧基-9,10-二氫菲
英文名稱
7-Methoxy-9,10-dihydrophenanthrene-2,5-diol
CAS
87530-30-1
分子式
C15H14O3
分子量
242.27
MOL 文件
87530-30-1.mol
更新日期
2024/12/15 17:53:37
87530-30-1 結(jié)構(gòu)式
基本信息
中文別名
4,7-二羥基-2-甲氧基-9,10-二氫菲 英文別名
Lusianthridin9,10-Dihydro-2-methoxyphenanthrene-4,7-diol
7-Methoxy-9,10-dihydrophenanthrene-2,5-diol
2,5-Phenanthrenediol, 9,10-dihydro-7-methoxy-
4,7-dihydroxy-2-methoxy-9,10-dihydrophenanthrene
所屬類別
化學(xué)試劑：多環(huán)化合物物理化學(xué)性質(zhì)
沸點507.3±50.0 °C(Predicted)
密度1.296±0.06 g/cm3(Predicted)
儲存條件-20°C儲存
溶解度Soluble in Chloroform,Dichloromethane,Ethyl Acetate,DMSO,Acetone,etc.
酸度系數(shù)(pKa)9.23±0.20(Predicted)
形態(tài)粉末
顏色White to off-white
常見問題列表
生物活性
Lusianthridin 是來自 Dendrobium venustum 的天然化合物，具有抗遷移作用。Lusianthridin 通過抑制Src-STAT3 信號，促進c-Myc 的降解。體外研究
Lusianthridin (0-100 μM) inhibits cell viability at concentrations greater than 50 μM in both H460 and H292 cells.
Lusianthridin significantly reduces the CSC populations in both H460 and H292 cells of the CSC spheres, with a significant decrease in the size of the H460 CSC spheres by approximately 10%, 63%, and 77% at day 3 at concentration 5, 10, and 20 μM Lusianthridin, respectively.
Cell Viability Assay
| Cell Line: | The human non-small cell lung cancer cell lines, NCI-H460, and NCI-H292 cells [1] . 0-100 μM. |
| Concentration: | 0-100 μM. |
| Incubation Time: | 24 h. |
| Result: | Caused a significant reduction in terms of cell viability at concentrations greater than 50 μM in both H460 and H292 cells. |