Properties, use and production process of Noron phenylpropionate

Commonly used hormone

Noron phenylpropionate is a hormone commonly used to promote protein anabolism, known as Nandrolone benpropionate, nortestosterone phenylpropionate, doreboron, and Doreborin. It was prepared by esterification of 19- demethyltestosterone and phenylpropionyl chloride. It is an oily injection and is administered by intramuscular injection. Can promote protein synthesis and calcium, phosphorus, potassium accumulation, for severe osteoporosis, premature infants, growth retardation, dwarfism, severe malnutrition, etc. Also can be used for unfavorable operation of breast cancer, functional uterine bleeding, uterine fibroids, etc. But this product may have a slight masculine effect; Not suitable for long-term use; Prostatic cancer, hypertension, pregnant women contraindicated; Use with caution if heart, liver and kidney are not good. This information was compiled by Xiang Yun of ChemicalBook. Physical and chemical properties white or milky white crystalline powder, with special odor. Melting point 95 ~ 99℃, relative density 1.14g/cm3, [α]D20+48 ~ +51℃(dioxane). Soluble in ethanol, camellia oil, slightly soluble in vegetable oil; Almost insoluble in water. Pharmacological effects This product protein assimilation of testosterone propionate 12 times, androgen activity is smaller, 1.5 times of the latter, can promote protein synthesis and inhibit protein heterogenesis, and make calcium phosphorus deposition and promote bone tissue growth and other effects. The effect of intramuscular injection can last 1 ~ 2 weeks. Pharmacokinetic metabolism: Hormones are excreted through urine, mostly in conjugated form, whereas hormones are excreted mainly in free form in faeces, while the main metabolite of norone and norandrostenediol in urine is 19-norandrostenediol (19-NA). Indications dermatology for adjunctive treatment with the application of high doses of corticosteroids to cause negative nitrogen balance while increasing protein in food; Also used for peeling dermatitis, pemphigus, dermatomyositis, scleroderma, senile pruritus. In addition, severe burns, malignant tumors before and after surgery, non-healing after fractures and severe osteoporosis, early Chemicalbook births, significant growth retardation, dwarfism, severe malnutrition, loss of appetite, chronic diarrhea and other serious wasting diseases may be given in conjunction with other treatments. Unfavorable operation of breast cancer can reduce symptoms, functional uterine bleeding, uterine fibroids can be applied. Function and use for assimilation hormone, the main role is to promote protein synthesis, inhibit protein decomposition, muscle growth, weight increase, but also can make water, sodium, calcium, phosphorus retention. It is mainly used for the cases of insufficient protein synthesis and increased decomposition, such as malnutrition, stunting in children, severe burns, recovery period after surgery, fracture not easy to heal, osteoporosis in the elderly and chronic wasting diseases (such as chronic liver and kidney diseases, advanced malignant tumors, hyperthyroidism and anemia); It is also used for negative nitrogen balance caused by long-term heavy use of glucocorticoids, but the protein content of food should be increased at the same time. This product has different odor, almost insoluble in water, soluble in ethanol, fat oil. Adverse reactions have a slight masculine effect, women may appear hairy, acne, coarse voice, clitoral hypertrophy, amenorrhea or menstrual disorders. If this occurs, stop taking the medicine immediately. Long-term use can cause jaundice and liver dysfunction. Edema can also occur because of water and sodium retention. Drug interaction 1. When used with oral anticoagulant, the curative effect of the latter can be improved and bleeding tendency can be increased. 2. Anabolic hormones can reduce glucose tolerance. Diabetic patients should pay attention to adjusting the dosage of insulin or oral hypoglycemic drugs when using them. 3. Other homotestosterone. Precautions (1) Liver disease, kidney disease, hypertension, prostate cancer, breast cancer and pregnant women should not use. (2) It should not be used by healthy children. (3) Patients with benign prostatic hypertrophy, myocardial infarction or a history of coronary atherosclerosis should be used with caution. (4) This product is strictly prohibited to be used as a nutritional product for a long time for normal people. (5) Nutrition, especially protein, should be increased during medication. (6) Deep intramuscular injection is required. It is used for the treatment of stunting, malnourishment and wasting diseases.