
Clofarabine NEW
Price | Get Latest Price |
Package | 1g |
Min. Order: | 1g |
Supply Ability: | 1000G |
Update Time: | 2025-04-24 |
Product Details
Product Name: Clofarabine | CAS No.: 123318-82-1 |
EC-No.: 631-422-9 | Min. Order: 1g |
Purity: 99%min HPLC | Supply Ability: 1000G |
Release date: 2025/04/24 | |
Type: SZ01 |
Clofarabine is a purine nucleoside analog chemotherapy drug approved for treating relapsed or refractory acute lymphoblastic leukemia (ALL) in pediatric patients (1–21 years old).
Key Features:
Mechanism: Mimics nucleosides, inhibiting DNA synthesis by terminating chain elongation and blocking ribonucleotide reductase, disrupting DNA repair/replication. Also induces apoptosis.
Administration: Intravenous infusion.
Clinical Use: Second-line therapy for ALL unresponsive to prior treatments. Investigated for acute myeloid leukemia (AML) and other malignancies.
Side Effects: Myelosuppression, infections, nausea, hepatotoxicity, capillary leak syndrome, and renal toxicity. Requires close monitoring.
FDA Approval: Approved in 2004, offering an option for aggressive/resistant pediatric ALL.
A potent but high-risk therapy, it balances efficacy with stringent safety protocols due to its toxicities.
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- Since: 2006-04-03
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