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Postion:Product Catalog >Chemical Reagents>Organic reagents>Cyclodextrin> β-Cyclodextrin, sulfobutyl ethers, sodium salts
	β-Cyclodextrin, sulfobutyl ethers, sodium salts
  • 	β-Cyclodextrin, sulfobutyl ethers, sodium salts

β-Cyclodextrin, sulfobutyl ethers, sodium salts

Price $547
Package 1KG
Min. Order: 100g
Supply Ability: 25kg
Update Time: 2024-11-14

Product Details

Product Name: β-Cyclodextrin, sulfobutyl ethers, sodium salts CAS No.: 182410-00-0
EC-No.: 1308068-626-2 Min. Order: 100g
Purity: 99% Supply Ability: 25kg
Release date: 2024/11/14

Solubleinwater. Insolubleinacetone, methanol, chloroform. Form Solidpowder Color Whitetooffwhite Sulfobutyl-beta-cyclodextrin Purpose and synthesis method Purpose Sulfobutyl ether-beta-cyclodextrin sodium is a new type of pharmaceutical excipients, belonging to anionic type A sulfonic acid derivative of highly water-soluble cyclodextrin. It can be well included with drug molecules to form non-covalent complexes, improve the stability, water solubility, safety of the drug, and effectively improve the biological activity of the drug molecule. It has low nephrotoxicity and can alleviate the hemolysis of the drug. , Control the drug release rate. The preparation uses β-cyclodextrin and 1,4-sulfobutyrolactone as raw materials. By introducing an appropriate amount of organic solvent into the alkaline aqueous solution, the solubility of 1,4-sulfobutyrolactone is increased, and the sulfobutyl ether- Synthesis yield of β-cyclodextrin; the obtained product solution is subjected to ultrasonic dialysis, activated carbon decolorization, freeze-drying and other operations to obtain sulfobutyl ether-β-cyclodextrin powder product. Biologically active Captisol (SBE-β-CD, Sulfobutylether-β-Cyclodextrin) is a new type of chemically modified cyclodextrin with relatively good stability and solubility. In vitro studies SBE-β-CDisachemicallymodifiedβ-CDthatisacyclichydrophilicoligosaccharidewhichisnegativelychargedinaqueousmedia.β-CDfunctionedisasolubilizeronlyatlowconceChemicalbookntrations, whereasSBE7-β-CDexhibitsstrongsolubilizingeffectsoverawideconcentrationrange vivo studies 20% SBE-β-CDinsaline: Guidelines (Followingisourrecommendedprotocol.Thisprotocolonlyprovidesaguideline, andshouldbemodifiedaccordingtoyourspecificneeds) .1.Dissolve0.9gofNaClin100mLdistilledwatertomakeaclear0.9% salinesolution.2 .Measure2gofdrySBE-β-CD.3.Dissolve2gofSBE-β-CDin0.9%salinetomake10mLwitha20%(w/v)concentration.Thesemay requireultrasonic(20-40kHz,30seconds,repeat3times)orheating(37°Cforabout30minutes)orheating(37°Cforabout30minutes).

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