Product Details
| Product Name:
2-(1-(4-Chlorophenylmethyl)-1H-indol-3-yl)-2-oxo-N-(pyridin-4-yl)acetamide |
CAS No.:
204205-90-3 |
| Min. Order:
1KG |
Purity:
95%~99.99% |
| Supply Ability:
10 MT/ Month |
Release date:
2024/10/22 |
| Delivery Time::
Fast |
Transportation::
By sea， express， air，railway |
| Port::
Shanghai，Tianjin or Qingdao |
Package::
Drum/ Bottle/ Bag/ IBC TANK |
| Name:
Heidi 18 |
Heidi 18
| 2-(1-(4-Chlorophenylmethyl)-1H-indol-3-yl)-2-oxo-N-(pyridin-4-yl)acetamide Basic information |
| Product Name: |
2-(1-(4-Chlorophenylmethyl)-1H-indol-3-yl)-2-oxo-N-(pyridin-4-yl)acetamide |
| Synonyms: |
2-[1-[(4-chlorophenyl)methyl]indol-3-yl]-2-oxo-N-pyridin-4-ylacetamide;Nascapine;ZIO 301;2-(1-(4-Chlorophenylmethyl)-1H-indol-3-yl)-2-oxo-N-(pyridin-4-yl)acetamide;Indibulin;2-[1-(4-Chlorobenzyl)-1H-indol-3-yl]-2-oxo-N-pyridin-4-ylacetamide;lindiblin |
| CAS: |
204205-90-3 |
| MF: |
C22H16ClN3O2 |
| MW: |
389.83 |
| EINECS: |
|
| Product Categories: |
Anticancer. |
| Mol File: |
204205-90-3.mol |
 |
| |
| 2-(1-(4-Chlorophenylmethyl)-1H-indol-3-yl)-2-oxo-N-(pyridin-4-yl)acetamide Chemical Properties |
| density |
1.31±0.1 g/cm3(Predicted) |
| storage temp. |
Desiccate at -20°C |
| pka |
9.38±0.70(Predicted) |
| |
| 2-(1-(4-Chlorophenylmethyl)-1H-indol-3-yl)-2-oxo-N-(pyridin-4-yl)acetamide Usage And Synthesis |
| Biological Activity |
Microtubule destabilizer that blocks tubulin polymerization (IC 50 = 0.3 μ M). Blocks cell cycle progression at metaphase and displays antitumor activity against a variety of malignancies in vitro (IC 50 values ranging from 0.036-0.285 μ M). Induces complete tumor remission in the Yoshida AH13 rat sarcoma model in vivo . Lacks neurotoxicity due to an ability to discriminate between posttranslationally modified tubulin in mature neuronal microtubules and less-modified tubulin present in immature neuronal or nonneuronal microtubules. Displays oral availability and efficacy towards MDR tumor cells. |
Company Profile Introduction
Technology research and transfer of pilot screening, pilot scale-up and mass production solutions , for pharmaceutical intermediates, biologicals and fine chemicals (Not including inflammable , explosive , hazardous goods ) ; Market : Nano material , metal catalyst , raw material of cosmetics , pharmaceutical intermediates , chemicals , photoelectric material , import and export of technology and goods (For projects subject to approval according to law, business activities can be carried out only after approval by relevant departments ).
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