11-Beta-hydroxyandrostenedione NEW
| Price | $39 | $64 | $128 |
| Package | 5mg | 10mg | 25mg |
| Min. Order: | |
| Supply Ability: | 10g |
| Update Time: | 2024-11-14 |
Product Details
| Product Name: 11-Beta-hydroxyandrostenedione | CAS No.: 382-44-5 |
| Purity: 98.96% | Supply Ability: 10g |
| Release date: 2024/11/14 |
Product Introduction
Bioactivity
| 名稱 | 11-Beta-hydroxyandrostenedione |
| 描述 | 11-Beta-hydroxyandrostenedione (NSC-17102) is a steroid mainly found in the adrenal origin (11β-hydroxylase is present in adrenal tissue, but absent in ovarian tissue), which is a 11β-hydroxysteroid dehydrogenase isozymes inhibitor. Measuring plasma 11-Beta-hydroxyandrostenedione can distinguish the adrenal or ovarian origin of hyperandrogenism with 4-androstenedione increases. |
| 體外活性 | 21-deoxycortisol (21dF) and 21-deoxycortisone (21dE) are assayed within the LNCaP cell line to establish that this conversion is catalyzed by the lyase activity of CYP17A1. After the transfection of CYP17A1, 11-Beta-hydroxyandrostenedione (11OHA4)-pathway metabolites increase, 21dF, and 21dE are in fact metabolized to 11-Beta-hydroxyandrostenedione and 11-ketoprogesterone (11KP4) by CYP17A1, respectively [2]. |
| 體內(nèi)活性 | In 21-hydroxylase deficiency, Cushing's syndrome, and hyperandrogenism of adrenal origin, the plasma concentration of 11-Beta-hydroxyandrostenedione (11beta-hydroxy-4-androstene-3,17-dione) is very high. In congenital 11-hydroxylase deficiency and adrenal insufficiency, the plasma concentration of 11-Beta-hydroxyandrostenedione (11beta-hydroxy-4-androstene-3,17-dione) is very low. Thus, when plasma 4-androstenedione is elevated, it is useful to measure the plasma 11-Beta-hydroxyandrostenedione level in order to determine the adrenal or ovarian origin of the hyperandrogenism [1]. |
| 存儲條件 | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice. |
| 溶解度 | DMSO : 45 mg/mL (148.8 mM), Sonication is recommended. |
| 關(guān)鍵字 | 11Betahydroxyandrostenedione | inhibit | 4-androstenedione | Cushing's | hyperandrogenism | adrenal | syndrome | Inhibitor | NSC17102 | 4-Androsten-11b-ol-3,17-dione | Endogenous Metabolite | 4-Androsten-11beta-ol-3,17-dione | NSC 17102 | steroid | 11-Beta-hydroxyandrostenedione | 11-β-hydroxyandrostenedione | 11 Beta hydroxyandrostenedione | 11-b-hydroxyandrostenedione | 11β-hydroxylase | ovarian |
| 相關(guān)產(chǎn)品 | Sucrose | Daidzein | Guanidine hydrochloride | Fumaric acid | Ferulic Acid | Vanillin | Formamide | Glycerol | Thymidine | Naringin | 3-Indoleacetic acid | Oleic acid |
| 相關(guān)庫 | 經(jīng)典已知活性庫 | ReFRAME 相關(guān)化合物庫 | 天然產(chǎn)物庫 | 抑制劑庫 | NO PAINS 化合物庫 | 高通量篩選天然產(chǎn)物庫 | Ro5類藥天然產(chǎn)物庫 | 人內(nèi)源代謝化合物庫 | 已知活性化合物庫 | 小鼠代謝化合物庫 |
Company Profile Introduction
Target Molecule Corp. (TargetMol) is a global high-tech enterprise, headquartered in Boston, MA, specializing in chemical and biological research product and service to meet the research needs of global customers.
TargetMol has evolved into one of the biggest global compound library and small molecule suppliers and a customer based on 40+ countries. TargetMol offers over 80 types of compound libraries and a wide range of high-quality research chemicals including inhibitors, activator, natural compounds, peptides, inhibitory antibodies, and novel life-science kits, for laboratory and scientific use. Besides, virtual screening service is also available for customers who would like to conduct the computer-aided drug discovery.
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