IGF DES
Price | $1 |
Package | 1kg |
Min. Order: | 0.1KG |
Supply Ability: | 20 tons |
Update Time: | 2023-02-22 |
Product Details
Product Name: IGF DES | CAS No.: 67763-96-6 |
Min. Order: 0.1KG | Purity: 99% |
Supply Ability: 20 tons | Release date: 2023/02/22 |
IGF-1 LR3, also known as Long-Arginine-3-IGF-1, is an analogue of human IGF-1 that has been modified to include a 13 amino acid N-terminus extension and the substitution of Arginine for Glutamic Acid at position 3. As a result of these modifications, IGF-1 LR3 is approximately three times more potent than IGF-1 and possesses an increased half-life due to lowered affinity for binding to the Insulin-Like Growth Factor-Binding Proteins (IGFBPs). IGF-1 LR3 retains the ability to bind agonistically to the IGF-1 receptor with improved metabolic stability, relative to IGF-1.
The supplementation of mammalian cell cultures with Long R3 IGF-1 at a much lower concentration results in more highly elevated productivity than with standard concentrations of insulin and/or standard IGF-1. IGF-1 LR3 is more able to stimulate the type 1 IGF receptor and thus induce a higher level of activation of intracellular signaling, which is responsible for promoting cell proliferation and the inhibition of apoptosis.
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- Since: 2016-06-27
- Address: Guanggu avenue, East Lake High-tech district , Wuhan, Hubei, China