天堂网亚洲,天天操天天搞,91视频高清,菠萝蜜视频在线观看入口,美女视频性感美女视频,95丝袜美女视频国产,超高清美女视频图片

Welcome to chemicalbook!
+1 (818) 612-2111
Inquriy
Try our best to find the right business for you.
Do not miss inquiry messages Please log in to view all inquiry messages.

Welcome back!

RFQ
skype
MY Account
Top
Postion:Product Catalog >Biochemical Engineering>Chinese Herbs>(-)-Epicatechin
(-)-Epicatechin
  • (-)-Epicatechin

(-)-Epicatechin NEW

Price $53 $67 $86
Package 10mg 25mg 50mg
Min. Order:
Supply Ability: 10g
Update Time: 2024-11-19

Product Details

Product Name: (-)-Epicatechin CAS No.: 490-46-0
Purity: ≥95% Supply Ability: 10g
Release date: 2024/11/19

Product Introduction

Bioactivity

Name(-)-Epicatechin
Description(-)-Epicatechin (Epicatechin) is an inhibitor of cyclooxygenase-1 (COX-1), inhibiting the IL-1β-induced expression of iNOS by blocking the nuclear localization of the p65 subunit of NF-κB.
Cell ResearchPanc-1 cells are seeded into T-150 flasks and on the next day, cells are treated with different concentrations of (-)-epicatechin for 1 h, then harvested and solubilized in 10 mM HEPES (pH 7.4), 40 mM KCl, 1%Tween-20, 1 μM oligomycin, 1 mM PMSF,10 mM KF, 2 mM EGTA, and 1 mM Na3VO4. COX activity is measured in the presence of 20 mM ascorbate and 200 μM substrate cytochrome c from cow heart.(Only for Reference)
In vitro(-)-Epicatechin stimulates mitochondrial respiration and oxygen consumption in Panc-1 cells. Human normal fibroblasts are not affected. (-)-Epicatechin sensitizes Panc-1, U87, and MIA PaCa-2 cells with an average radiation enhancement factor (REF) of 1.7, 1.5, and 1.2, respectively. (-)-Epicatechin does not sensitize normal fibroblast cells to ionizing radiation with a REF of 0.9, suggesting cancer cell selectivity. (-)-Epicatechin enhances Chk2 phosphorylation and p21 induction when combined with radiation in cancer, but not normal cells[2].
In vivoAging has deleterious effects on modulators of muscle growth/differentiation, the consumption of modest amounts of the flavanol (-)-Epicatechin can partially reverse these changes. In mice, myostatin and senescence-associated β-galactosidase levels increase with aging, while those of follistatin and Myf5 decrease. (-)-Epicatechin decreases myostatin and β-galactosidase and increases levels of markers of muscle growth. In humans, myostatin and β-galactosidase increase with aging while follistatin, MyoD and myogenin decrease. Treatment for 7 days with (-)-Epicatechin increases hand grip strength and the ratio of plasma follistatin/myostatin[1]. Low-dose (-)-Epicatechin treatment resulted in significant increases in skeletal muscle capillarity, mitochondrial biogenesis, and oxidative enzyme activity, which corresponded to lower muscle fatigue and higher endurance capacity when compared to the placebo group. (-)-Epicatechin may potentially regulate the protein expression between angiogenic and antiangiogenic factors, such as VEGF-A and TSP-1, respectively[3].
StoragePowder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice.
Solubility InformationEthanol : < 1 mg/mL (insoluble or slightly soluble)
H2O : 2.25 mg/mL (7.75 mM), Sonication is recommended.
DMSO : 45 mg/mL (155.02 mM)
KeywordsEpicatechol | epi-Catechin | Endogenous Metabolite | Inhibitor | Ferroptosis | COX | inhibit | ( ) Epicatechin | Cyclooxygenase | ()Epicatechin
Inhibitors RelatedSucrose | Daidzein | Guanidine hydrochloride | Fumaric acid | Ferulic Acid | Formamide | Oleamide | Glycerol | Thymidine | Naringin
Related Compound LibrariesPain-Related Compound Library | Bioactive Compound Library | Traditional Chinese Medicine Monomer Library | Selected Plant-Sourced Compound Library | Miao medicine Compound Library | Natural Product Library | Bioactive Compounds Library Max | Ancient Chinese Classical Formulas Compound Library | Anti-Cancer Drug Library | Food as Medicine Compound Library

Company Profile Introduction

Target Molecule Corp. (TargetMol) is a global high-tech enterprise, headquartered in Boston, MA, specializing in chemical and biological research product and service to meet the research needs of global customers. TargetMol has evolved into one of the biggest global compound library and small molecule suppliers and a customer based on 40+ countries. TargetMol offers over 80 types of compound libraries and a wide range of high-quality research chemicals including inhibitors, activator, natural compounds, peptides, inhibitory antibodies, and novel life-science kits, for laboratory and scientific use. Besides, virtual screening service is also available for customers who would like to conduct the computer-aided drug discovery.

You may like

Recommended supplier

Product name Price   Suppliers Update time
$10.00/1KG
VIP6Y
Hebei Weibang Biotechnology Co., Ltd
2024-11-29
$10.50/1KG
VIP4Y
Hebei Chuanghai Biotechnology Co,.LTD
2024-08-09
$62.00/1kg
VIP1Y
Hebei Zhuanglai Chemical Trading Co.,Ltd
2024-05-24
$0.00/25kg
Shaanxi Haibo Biotechnology Co., Ltd
2023-09-07
$100.00/1bag
Hebei Fengqiang Trading Co., LTD
2023-09-01
$10.00/1KG
VIP5Y
Hebei Mojin Biotechnology Co., Ltd
2023-08-17
$0.00/1kg
VIP2Y
Wuhan Haorong Biotechnology Co.,Ltd
2023-08-11
$0.00/25kg
VIP2Y
Chengdu ChenLv Herb Co.,Ltd
2023-08-03
$800.00/1Kg/Bag
VIP4Y
XI'AN TIANGUANGYUAN BIOTECH CO., LTD.
2023-06-01
$0.00/25kg
PNP Biotech Co. Ltd
2022-10-25
  • Since: 2011-01-07
  • Address: 36?Washington?Street, Wellesley?Hills
INQUIRY