β-Elemene NEW
| Price | $68 | $166 |
| Package | 20mg | 100mg |
| Min. Order: | |
| Supply Ability: | 10g |
| Update Time: | 2024-11-19 |
Product Details
| Product Name: β-Elemene | CAS No.: 515-13-9 |
| Purity: 99.35% | Supply Ability: 10g |
| Release date: 2024/11/19 |
Product Introduction
Bioactivity
| Name | β-Elemene |
| Description | β-Elemene (Levo-β-elemene) is a natural product isolated from Curcuma wenyujin, with an antitumor activity and induce cell apoptosis. |
| Cell Research | Cell viability assay was used to assess the resistance of SGC7901/ADR cells and the cytotoxic effects of β-Elemene.?Wound healing, transwell assay and lung metastatic mice model were used to the anti-metastasis effects of β-Elemene.?MicroRNA microarray analysis was used to explore potential regulated miRNAs.?Luciferase reporter assay was used to identify the direct target.?Human MMP antibody array, western blot, immunoprecipitation, qRT-PCR analyses and immunohistochemistry were conducted to investigate the underlying anti-metastasis mechanism of β-Elemene[3]. |
| In vitro | β-Elemene significantly inhibited the metastatic capacity of MDR gastric cells in vivo and in vitro.?Mechanistically, β-Elemene regulated MMP-2/9 expression and reversed epithelial-mesenchymal transition.?β-Elemene upregulated Cbl-b expression, resulting in inhibition of the EGFR-ERK/AKT pathways, which regulate MMP-2/9.?β-Elemene upregulated Cbl-b by inhibiting miR-1323 expression.?Numbers of metastatic tumor nodules were significantly decreased in the lungs of nude mice after β-Elemene treatment.?β-Elemene inhibits the metastasis of MDR gastric cancer cells by modulating the miR-1323/Cbl-b/EGFR signaling axis[3]. |
| Storage | store under nitrogen | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice. |
| Solubility Information | DMSO : 55 mg/mL (269.15 mM), Sonication is recommended. |
| Keywords | Levo-b-elemene | Apoptosis | Inhibitor | beta-Elemene | inhibit | Levo-beta-elemene | β Elemene | βElemene | β-Elemene | b-Elemene |
| Inhibitors Related | Stavudine | 5-Fluorouracil | Myricetin | Meclizine dihydrochloride | Dextran sulfate sodium salt (MW 4500-5500) | Sodium 4-phenylbutyrate | L-Ascorbic acid | Metronidazole | Sorafenib | Tributyrin | Salicylic acid | Oleic acid |
| Related Compound Libraries | Bioactive Compound Library | Drug Repurposing Compound Library | Natural Product Library | Tobacco Monomer Library | Ancient Chinese Classical Formulas Compound Library | Food as Medicine Compound Library | Anti-Cancer Active Compound Library |
Company Profile Introduction
Target Molecule Corp. (TargetMol) is a global high-tech enterprise, headquartered in Boston, MA, specializing in chemical and biological research product and service to meet the research needs of global customers.
TargetMol has evolved into one of the biggest global compound library and small molecule suppliers and a customer based on 40+ countries. TargetMol offers over 80 types of compound libraries and a wide range of high-quality research chemicals including inhibitors, activator, natural compounds, peptides, inhibitory antibodies, and novel life-science kits, for laboratory and scientific use. Besides, virtual screening service is also available for customers who would like to conduct the computer-aided drug discovery.
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