β-catenin-IN-6 NEW
| Price | Get Latest Price | |
| Package | 5mg | 50mg |
| Min. Order: | |
| Supply Ability: | 10g |
| Update Time: | 2024-11-19 |
Product Details
| Product Name: β-catenin-IN-6 | CAS No.: 1039731-99-1 |
| Supply Ability: 10g | Release date: 2024/11/19 |
Product Introduction
Bioactivity
| Name | β-catenin-IN-6 |
| Description | β-Catenin-IN-6 is an inhibitor of the canonical Wnt/β-catenin signaling pathway, effectively impeding the proliferation of human colorectal cancer cells and demonstrating efficacy in a β-catenin/RK3E mouse model [1] [2]. |
| In vitro | β-Catenin-IN-6 (compound 9) demonstrates inhibitory effects on LoVo and HT29 cells after a 24-hour exposure, with IC50 values of 1.4 μM and 1.37 μM, respectively. This compound exhibits growth inhibition in several human colorectal cancer cell lines [1]. |
| In vivo | β-catenin-IN-6 (compound 9) exhibits poor bioavailability [1]. Administered intraperitoneally at a dosage of 18.75 mg/kg daily for seven days, it reduces tumor volume in mice without affecting body weight [1]. At 150 mg/kg once weekly, β-catenin-IN-6 (compound 13) inhibits ectopic tumor growth in the β-catenin/RK3E mouse model [2]. |
| Storage | Shipping with blue ice. |
Company Profile Introduction
TargetMol Chemicals Inc. is headquartered in Boston, MA, and specializes in products and services that serve the research needs of chemical and biological scientists worldwide. With a client base in 40+ countries, TargetMol has evolved into one of the biggest global research suppliers for compound libraries and small molecule compounds.
170+ Compound Libraries， 10000+ Noval Small Molecucles，16000+ Nature Compounds
TargetMol diligently updates and offers over 170 types of compound libraries and a wide range of high-quality research chemicals, including inhibitors, activators, natural products, peptides, antibodies , and novel life-science kits for laboratory and scientific use. In addition, our lab allows us to conduct CADD (computer-aided drug design) and chemical synthesis to meet the customization needs of our clients.
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United States- Since: 2011-01-07
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