天堂网亚洲,天天操天天搞,91视频高清,菠萝蜜视频在线观看入口,美女视频性感美女视频,95丝袜美女视频国产,超高清美女视频图片

Welcome to chemicalbook!
+1 (818) 612-2111
Inquriy
Try our best to find the right business for you.
Do not miss inquiry messages Please log in to view all inquiry messages.

Welcome back!

RFQ
skype
MY Account
Top
Postion:Product Catalog >Biochemical Engineering>Natural Products> Astragaloside A
	Astragaloside A
  • 	Astragaloside A
  • 	Astragaloside A

Astragaloside A NEW

Price $8 $6 $1
Package 1KG 25KG 100KG
Min. Order: 1KG
Supply Ability: g-kg-tons, free sample is available
Update Time: 2024-03-29

Product Details

Product Name: Astragaloside A CAS No.: 83207-58-3
Min. Order: 1KG Purity: 99%
Supply Ability: g-kg-tons, free sample is available Release date: 2024/03/29
Lead time: In stock, ready for shipment Packaging: bag/bottle/drum/IBC
Delivery: By express, by air, by sea Origin: Manufacturer, advantage product
CCOA, MSD: Available, contact us for details Name: Sun

 1. Materials information

Names

Nameastragaloside IV
SynonymMore Synonyms

 Astragaloside A Biological Activity

DescriptionAstragaloside A is one of the major active constituents of Astragalus membranaceus in Traditional Chinese Medicine; has been widely used to treat ischemic diseases.IC50 value: Target: in vitro: AS-IV treatment promotes umbilical vein endothelial cells (HUVEC) proliferation, migration, and tube formation. AS-IV treatment also activates JAK2/STAT3 and ERK1/2 signaling pathways, and up-regulates endothelial nitric oxide synthase (eNOS) expression and nitric oxide (NO) production [1]. Administration of astragaloside IV (16, 32, and 64 μM) 1 h prior to lipopolysaccharide stimulation dose-dependently attenuated cardiac hypertrophy induced by lipopolysaccharide. Further studies demonstrated that astragaloside IV inhibited the increment of the resting intracellular free Ca2+, and its effect was similar to verapamil [2]. ASI could inhibit cells apoptosis induced by high glucose (25mmol/L) in dose-dependent and time-dependent manners. ASI also inhibited high glucose-induced expression of TGF-β1 and activation of p38 MAPK pathway at the protein level. Furthermore, ASI increased HGF production in human tubular epithelial cells [3].in vivo: the growth of tumor was suppressed by AS-IV treatment in vivo. AS-IV also could down-regulate regulatory T cells (Tregs) and up-regulate cytotoxic T lymphocytes (CTLs) in vivo and in vitro[4]. As an in vivo model, mice subjected to unilateral ureteral obstruction (UUO) were administered AS-IV (20 mg/kg) by intraperitoneal injection for 7 days. AS-IV significantly alleviated renal mass loss and reduced the expression of α-smooth muscle actin, fibronectin, and collagen IV both in vitro and in vivo [5].
Related Catalog
Signaling Pathways >> Others >> Others
Natural Products >> Terpenoids and Glycosides
Research Areas >> Cancer
References

[1]. Wang SG, et al. Astragaloside IV stimulates angiogenesis and increases nitric oxide accumulation via JAK2/STAT3 and ERK1/2 pathway. Molecules. 2013 Oct 16;18(10):12809-19.

[2]. Lu M, et al. Astragaloside IV protects against cardiac hypertrophy via inhibiting the Ca2+/CaN signaling pathway. Planta Med. 2014 Jan;80(1):63-9.

[3]. Wang Q, et al. Astragalosides IV inhibits high glucose-induced cell apoptosis through HGF activation in cultured human tubular epithelial cells. Ren Fail. 2014 Apr;36(3):400-6.

[4]. Zhang A, et al. Astragaloside IV inhibits progression of lung cancer by mediating immune function of Tregs and CTLs by interfering with IDO. J Cancer Res Clin Oncol. 2014 Nov;140(11):1883-90.

[5]. Xu W, et al. Astragaloside IV ameliorates renal fibrosis via the inhibition of mitogen-activated protein kinases and antiapoptosis in vivo and in vitro. J Pharmacol Exp Ther. 2014 Sep;350(3):552-62.

 Chemical & Physical Properties

Density1.4±0.1 g/cm3
Boiling Point895.7±65.0 °C at 760 mmHg
Melting Point284-286oC
Molecular FormulaC41H68O14
Molecular Weight784.970
Flash Point495.5±34.3 °C
Exact Mass784.460938
PSA228.22000
LogP1.96
Vapour Pressure0.0±0.6 mmHg at 25°C
Index of Refraction1.621
Storage condition2~8℃

 Safety Information

Hazard CodesXi
HS Code2932999099

 Synthetic Route

Previous 1/3 Next
Article illustration

astragaloside VII

CAS#:84687-46-7

~%

Article illustration

Astragaloside A

CAS#:83207-58-3

Article illustration

Cycloastragenol...

CAS#:86764-12-7

Literature: Chemical and Pharmaceutical Bulletin, , vol. 31, # 2 p. 716 - 722
Article illustration

Astragaloside VI

CAS#:84687-45-6

~%

Article illustration

Astragaloside A

CAS#:83207-58-3

Literature: Chemical and Pharmaceutical Bulletin, , vol. 31, # 2 p. 709 - 715
Article illustration

Astrasieversian...

CAS#:86764-11-6

~%

Article illustration

Astragaloside A

CAS#:83207-58-3

Literature: Chemical and Pharmaceutical Bulletin, , vol. 31, # 2 p. 698 - 708

 Precursor & DownStream

Precursor  7

Previous 1/2 Next

  • Article illustration CAS#:84687-46-7
    astragaloside VII

  • Article illustration CAS#:84687-45-6
    Astragaloside VI

  • Article illustration CAS#:86764-11-6
    Astrasieversian...

  • Article illustration CAS#:84676-88-0
    Isoastragaloside I

DownStream  2



  • Article illustration CAS#:84605-18-5
    Cycloastragenol

  • Article illustration CAS#:86764-12-7
    Cycloastragenol...

 Customs

HS Code2932999099
Summary2932999099. other heterocyclic compounds with oxygen hetero-atom(s) only. VAT:17.0%. Tax rebate rate:13.0%. . MFN tariff:6.5%. General tariff:20.0%

 Synonyms

Astragalus Polysaccharides
(3β,6α,9β,16β,20R,24S)-16,25-Dihydroxy-3-(β-D-xylopyranosyloxy)-20,24-epoxy-9,19-cyclolanostan-6-yl β-D-glucopyranoside
ASTRAGALOSIDE
ASTRAGALOSIDE IV(RG)
Astrasieversianin XIV
Astragaloside IV
Astragaloside A
β-D-Glucopyranoside, (3β,6α,9β,16β,20R,24S)-20,24-epoxy-16,25-dihydroxy-3-(β-D-xylopyranosyloxy)-9,19-cyclolanostan-6-yl
cyclosiversioside F
cyclosieversioside F

2. Packaging of materials

  • For powders: normal is 25kgs/Drum or bag, or larger/smaller package as request.

  • For liquids: normal 25kgs/drum, 180-300kgs/bucket, or IBC, determined by the nature of the product. 

                             Or smaller package 1kg/bottle, 10kgs/bottle as request. 


Article illustrationArticle illustration


3. Shipping & Delivery

  • By Express

Provide door to door service

Suitable for goods under 50kg

Delivery: 3-7 days

Cost: low cost

Article illustration


  • By Air

Provide airport to airport service

Suitable for goods over 50kg

Delivery: 3-14 days

Cost: high cost

Article illustration


  • By Sea

Provide seaport to seaport service

Suitable for goods over 100kg

Delivery: 2-45 days

Cost: low cost

Article illustration


4. Contact information

For more details, pls contact us freely.

Email address: Sun@fdachem.com

Mob: 86 13526505137

WhatsApp/Skype/Wechat/LINE: 86 13526505137











Company Profile Introduction

Henan Fengda Chemical Co., Ltd. is located in the High-tech Development Zone of Henan Province. Specializing in the production and sales of various fine chemical products required for industrial production, including chemical raw materials, organic raw materials, petrochemicals, chemical reagents, solvents, catalysts, and additives, etc.

You may like

Recommended supplier

Product name Price   Suppliers Update time
$0.00/1kg
VIP1Y
BINBO BIOLOGICAL CO.,LTD
2024-12-02
$34.00/1mg
VIP5Y
TargetMol Chemicals Inc.
2024-11-19
$7.00/1g
VIP6Y
Chengdu King-tiger Pharm-chem. Tech. Co., Ltd.
2024-07-04
$0.00/1kg
VIP2Y
Hebei Kingfiner Technology Development Co.Ltd
2024-06-24
$0.00/1kg
VIP1Y
Shaanxi TNJONE Pharmaceutical Co., Ltd
2024-05-10
$0.00/25kg
Shaanxi Haibo Biotechnology Co., Ltd
2023-08-22
$0.00/1kg
VIP3Y
Changsha Staherb Natural Ingredients Co., Ltd.
2022-08-26
$1.00/10g
Guangzhou Biocar Biotechnology Co.,Ltd.
2022-01-14
$35.00/1g
Hebei Runbin Biotechnology Co. LTD
2020-08-24
$357.00/1KG
NanJing Spring & Autumn Biological Engineering CO., LTD.
2020-08-17
  • Since: 2023-02-10
  • Address: Room 01, 2288 E05, Building 14, East Henan University, Science and Technology Park, 279 Xisanhuan Ro
INQUIRY