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Postion:Product Catalog >API>Synthetic Anti-infective Drugs>Antiviral drugs> Acyclovir
Acyclovir
  • Acyclovir
  • Acyclovir

Acyclovir NEW

Price $8 $5 $1
Package 1KG 25KG 100KG
Min. Order: 1KG
Supply Ability: g-kg-tons, free sample is available
Update Time: 2024-04-09

Product Details

Product Name: Acyclovir CAS No.: 59277-89-3
Min. Order: 1KG Purity: 99%
Supply Ability: g-kg-tons, free sample is available Release date: 2024/04/09
Lead time: In stock, ready for shipment In stock: bag/bottle/drum/IBC
COA, MSDS: Available, contact us for details Origin: Manufacturer, advantage product
Origin: By express, by air, by sea NAME: Sun

1. Materials information

Names

Nameacyclovir
SynonymMore Synonyms

 Acyclovir Biological Activity

DescriptionAcyclovir, a molecule tailored to inactivate the thymidine kinase of the herpesvirus, is a guanosine analogue antiviral drug. It is a drug for HSV infection by GlaxoSmithKline.IC50 Value: 0.53-0.75 uM [3]Target: HSVin vitro: Acyclovir sensitivity was determined in a plaque-reduction assay in Vero cells. IC50 Values were consistently 2-3 fold lower in B2 compared with the H strain of Vero cells. HSV Type 2 strains were 2-10-fold less sensitive than Type 1 strains [2]. in vivo: two patients experienced a recurrence during treatment with oral acyclovir (200 mg 4 times daily) for up to 12 weeks, compared with nine during placebo treatment (P = 0.016). There was no difference between acyclovir and placebo in the time to the next recurrence following completion of treatment [3]. low-dose oral acyclovirmay be effective in the prevention of HSV infection during OKT3 treatment of seropositive patients. Continuation of acyclovir prophylaxis for two to four weeks following the conclusion of OKT3 therapy may prevent occurrence of delayed infections [4].Clinical trial: Acyclovir to Treat Patients Co-infected With HIV and Herpes Viruses in Uganda. Phage2
Related Catalog
Signaling Pathways >> Anti-infection >> HSV
Research Areas >> Infection
References

[1]. Li Z, et al. Acyclovir treatment of skin lesions results in immune deviation in mice infected cutaneously with herpes simplex virus. Antivir Chem Chemother. 1999 Sep;10(5):251-7.

[2]. Shelley WB, Hashim M, Shelley ED. Acyclovir in the treatment of hand-foot-and-mouth disease. Cutis. 1996 Apr;57(4):232-4.

[3]. Collins P, Oliver NM. Sensitivity monitoring of herpes simplex virus isolates from patients receiving acyclovir. J Antimicrob Chemother. 1986 Oct;18 Suppl B:103-12.

[4]. Meyrick Thomas RH, Dodd HJ, Yeo JM, Oral acyclovir in the suppression of recurrent non-genital herpes simplex virus infection. Br J Dermatol. 1985 Dec;113(6):731-5.

[5]. Tang IY, Maddux MS, Veremis SA, Low-dose oral acyclovir for prevention of herpes simplex virus infection during OKT3 therapy. Transplant Proc. 1989 Feb;21(1 Pt 2):1758-60.

 Chemical & Physical Properties

Density1.8±0.1 g/cm3
Boiling Point576.5±58.0 °C at 760 mmHg
Melting Point256-257°C
Molecular FormulaC8H11N5O3
Molecular Weight225.205
Flash Point302.4±32.3 °C
Exact Mass225.086182
PSA119.05000
LogP-3.31
Vapour Pressure0.0±1.7 mmHg at 25°C
Index of Refraction1.762
StabilityStable. Incompatible with strong oxidizing agents.
Water SolubilityH2O: 0.7 mg/mL

 MSDS

Acyclovir MSDS(Chinese)

 Toxicological Information

CHEMICAL IDENTIFICATION

  • RTECS NUMBER :

  • UP0791400

  • CHEMICAL NAME :

  • 6H-Purin-6-one, 1,9-dihydro-2-amino-9-((2-hydroxyethoxy)methyl)-

  • CAS REGISTRY NUMBER :

  • 59277-89-3

  • LAST UPDATED :

  • 199712

  • DATA ITEMS CITED :

  • 30

  • MOLECULAR FORMULA :

  • C8-H11-N5-O3

  • MOLECULAR WEIGHT :

  • 225.24

  • WISWESSER LINE NOTATION :

  • T56 BN DN FN HNJ D1O2Q GZ IQ &T56 BN DN FVM INJ B1O2Q HZ

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

  • TYPE OF TEST :

  • TDLo - Lowest published toxic dose

  • ROUTE OF EXPOSURE :

  • Oral

  • SPECIES OBSERVED :

  • Human - woman

  • DOSE/DURATION :

  • 28 mg/kg/2D-I

  • TOXIC EFFECTS :

  • Brain and Coverings - changes in surface EEG Behavioral - hallucinations, distorted perceptions Lungs, Thorax, or Respiration - sputum

  • TYPE OF TEST :

  • TDLo - Lowest published toxic dose

  • ROUTE OF EXPOSURE :

  • Oral

  • SPECIES OBSERVED :

  • Human - woman

  • DOSE/DURATION :

  • 12 mg/kg/1D-I

  • TOXIC EFFECTS :

  • Brain and Coverings - meningeal changes Behavioral - somnolence (general depressed activity) Behavioral - antipsychotic

  • TYPE OF TEST :

  • TDLo - Lowest published toxic dose

  • ROUTE OF EXPOSURE :

  • Oral

  • SPECIES OBSERVED :

  • Human - woman

  • DOSE/DURATION :

  • 100 mg/kg/5D-I

  • TOXIC EFFECTS :

  • Skin and Appendages - dermatitis, allergic (after systemic exposure)

  • TYPE OF TEST :

  • TDLo - Lowest published toxic dose

  • ROUTE OF EXPOSURE :

  • Oral

  • SPECIES OBSERVED :

  • Human - woman

  • DOSE/DURATION :

  • 80 mg/kg/4D-I

  • TOXIC EFFECTS :

  • Behavioral - somnolence (general depressed activity) Behavioral - hallucinations, distorted perceptions Behavioral - convulsions or effect on seizure threshold

  • TYPE OF TEST :

  • TDLo - Lowest published toxic dose

  • ROUTE OF EXPOSURE :

  • Oral

  • SPECIES OBSERVED :

  • Human - man

  • DOSE/DURATION :

  • 486 mg/kg/17D-I

  • TOXIC EFFECTS :

  • Gastrointestinal - decreased motility or constipation Gastrointestinal - other changes

  • TYPE OF TEST :

  • TDLo - Lowest published toxic dose

  • ROUTE OF EXPOSURE :

  • Intravenous

  • SPECIES OBSERVED :

  • Human - man

  • DOSE/DURATION :

  • 134 ug/kg/1D-I

  • TOXIC EFFECTS :

  • Behavioral - hallucinations, distorted perceptions

  • TYPE OF TEST :

  • TDLo - Lowest published toxic dose

  • ROUTE OF EXPOSURE :

  • Intravenous

  • SPECIES OBSERVED :

  • Human - woman

  • DOSE/DURATION :

  • 101 mg/kg/2D-I

  • TOXIC EFFECTS :

  • Behavioral - hallucinations, distorted perceptions Behavioral - muscle contraction or spasticity

  • TYPE OF TEST :

  • TDLo - Lowest published toxic dose

  • ROUTE OF EXPOSURE :

  • Intravenous

  • SPECIES OBSERVED :

  • Human - man

  • DOSE/DURATION :

  • 107 mg/kg/4D-I

  • TOXIC EFFECTS :

  • Behavioral - hallucinations, distorted perceptions Kidney, Ureter, Bladder - changes in tubules (including acute renal failure, acute tubular necrosis)

  • TYPE OF TEST :

  • LDLo - Lowest published lethal dose

  • ROUTE OF EXPOSURE :

  • Multiple routes

  • SPECIES OBSERVED :

  • Human - woman

  • DOSE/DURATION :

  • 36 mg/kg/2D-I

  • TOXIC EFFECTS :

  • Brain and Coverings - other degenerative changes Behavioral - coma Lungs, Thorax, or Respiration - other changes

  • TYPE OF TEST :

  • LD50 - Lethal dose, 50 percent kill

  • ROUTE OF EXPOSURE :

  • Oral

  • SPECIES OBSERVED :

  • Rodent - rat

  • DOSE/DURATION :

  • >20 gm/kg

  • TOXIC EFFECTS :

  • Details of toxic effects not reported other than lethal dose value

  • TYPE OF TEST :

  • LD50 - Lethal dose, 50 percent kill

  • ROUTE OF EXPOSURE :

  • Intraperitoneal

  • SPECIES OBSERVED :

  • Rodent - rat

  • DOSE/DURATION :

  • 860 mg/kg

  • TOXIC EFFECTS :

  • Details of toxic effects not reported other than lethal dose value

  • TYPE OF TEST :

  • LD50 - Lethal dose, 50 percent kill

  • ROUTE OF EXPOSURE :

  • Subcutaneous

  • SPECIES OBSERVED :

  • Rodent - rat

  • DOSE/DURATION :

  • 620 mg/kg

  • TOXIC EFFECTS :

  • Details of toxic effects not reported other than lethal dose value

  • TYPE OF TEST :

  • LD50 - Lethal dose, 50 percent kill

  • ROUTE OF EXPOSURE :

  • Intravenous

  • SPECIES OBSERVED :

  • Rodent - rat

  • DOSE/DURATION :

  • 750 mg/kg

  • TOXIC EFFECTS :

  • Details of toxic effects not reported other than lethal dose value

  • TYPE OF TEST :

  • LD50 - Lethal dose, 50 percent kill

  • ROUTE OF EXPOSURE :

  • Oral

  • SPECIES OBSERVED :

  • Rodent - mouse

  • DOSE/DURATION :

  • >10 gm/kg

  • TOXIC EFFECTS :

  • Details of toxic effects not reported other than lethal dose value

  • TYPE OF TEST :

  • LD50 - Lethal dose, 50 percent kill

  • ROUTE OF EXPOSURE :

  • Intraperitoneal

  • SPECIES OBSERVED :

  • Rodent - mouse

  • DOSE/DURATION :

  • 724 mg/kg

  • TOXIC EFFECTS :

  • Details of toxic effects not reported other than lethal dose value

  • TYPE OF TEST :

  • LD50 - Lethal dose, 50 percent kill

  • ROUTE OF EXPOSURE :

  • Subcutaneous

  • SPECIES OBSERVED :

  • Rodent - mouse

  • DOSE/DURATION :

  • 1118 mg/kg

  • TOXIC EFFECTS :

  • Details of toxic effects not reported other than lethal dose value

  • TYPE OF TEST :

  • LD50 - Lethal dose, 50 percent kill

  • ROUTE OF EXPOSURE :

  • Intravenous

  • SPECIES OBSERVED :

  • Rodent - mouse

  • DOSE/DURATION :

  • 1118 mg/kg

  • TOXIC EFFECTS :

  • Details of toxic effects not reported other than lethal dose value

  • TYPE OF TEST :

  • LD50 - Lethal dose, 50 percent kill

  • ROUTE OF EXPOSURE :

  • Intravenous

  • SPECIES OBSERVED :

  • Mammal - species unspecified

  • DOSE/DURATION :

  • 400 mg/kg

  • TOXIC EFFECTS :

  • Details of toxic effects not reported other than lethal dose value

  • TYPE OF TEST :

  • TDLo - Lowest published toxic dose

  • ROUTE OF EXPOSURE :

  • Intraperitoneal

  • SPECIES OBSERVED :

  • Rodent - rat

  • DOSE/DURATION :

  • 250 mg/kg/5D-I

  • TOXIC EFFECTS :

  • Kidney, Ureter, Bladder - changes primarily in glomeruli Kidney, Ureter, Bladder - urine volume increased Nutritional and Gross Metabolic - weight loss or decreased weight gain

  • TYPE OF TEST :

  • TDLo - Lowest published toxic dose

  • ROUTE OF EXPOSURE :

  • Oral

  • DOSE :

  • 60 mg/kg

  • SEX/DURATION :

  • female 5-6 week(s) after conception

  • TOXIC EFFECTS :

  • Reproductive - Specific Developmental Abnormalities - Central Nervous System

  • TYPE OF TEST :

  • TDLo - Lowest published toxic dose

  • ROUTE OF EXPOSURE :

  • Subcutaneous

  • DOSE :

  • 100 mg/kg

  • SEX/DURATION :

  • female 10 day(s) after conception

  • TOXIC EFFECTS :

  • Reproductive - Specific Developmental Abnormalities - musculoskeletal system Reproductive - Effects on Newborn - weaning or lactation index (e.g., # alive at weaning per # alive at day 4)

  • TYPE OF TEST :

  • TDLo - Lowest published toxic dose

  • ROUTE OF EXPOSURE :

  • Subcutaneous

  • DOSE :

  • 200 mg/kg

  • SEX/DURATION :

  • female 10 day(s) after conception

  • TOXIC EFFECTS :

  • Reproductive - Specific Developmental Abnormalities - craniofacial (including nose and tongue)

  • TYPE OF TEST :

  • TDLo - Lowest published toxic dose

  • ROUTE OF EXPOSURE :

  • Subcutaneous

  • DOSE :

  • 400 mg/kg

  • SEX/DURATION :

  • female 9-11 day(s) after conception

  • TOXIC EFFECTS :

  • Reproductive - Effects on Embryo or Fetus - fetotoxicity (except death, e.g., stunted fetus)

  • TYPE OF TEST :

  • TDLo - Lowest published toxic dose

  • ROUTE OF EXPOSURE :

  • Subcutaneous

  • DOSE :

  • 1200 mg/kg

  • SEX/DURATION :

  • female 1-20 day(s) after conception

  • TOXIC EFFECTS :

  • Reproductive - Maternal Effects - other effects Reproductive - Fertility - post-implantation mortality (e.g. dead and/or resorbed implants per total number of implants) Reproductive - Effects on Embryo or Fetus - fetotoxicity (except death, e.g., stunted fetus)

  • TYPE OF TEST :

  • TDLo - Lowest published toxic dose

  • ROUTE OF EXPOSURE :

  • Unreported

  • DOSE :

  • 300 mg/kg

  • SEX/DURATION :

  • female 10 day(s) after conception

  • TOXIC EFFECTS :

  • Reproductive - Effects on Embryo or Fetus - fetotoxicity (except death, e.g., stunted fetus)

MUTATION DATA

  • TYPE OF TEST :

  • DNA inhibition

  • TEST SYSTEM :

  • Rodent - rabbit Kidney

  • DOSE/DURATION :

  • 6800 ug/L

  • REFERENCE :

  • BCPCA6 Biochemical Pharmacology. (Pergamon Press Inc., Maxwell House, Fairview Park, Elmsford, NY 10523) V.1- 1958- Volume(issue)/page/year: 38,1771,1989

 Safety Information

Personal Protective EquipmentEyeshields;Gloves;type N95 (US);type P1 (EN143) respirator filter
Hazard CodesXi
Risk Phrases36/37/38
Safety PhrasesS22-S24/25
RIDADRNONH for all modes of transport
WGK Germany2
RTECSUP0791400
HS Code2933790090

 Synthetic Route

Previous 1/17 Next
Article illustration

9-[(2-Acetoxyet...

75128-73-3

~99%

Article illustration

Acyclovir

59277-89-3

Literature: Singh, Dharmendra; Wani, Mukesh J.; Kumar, Ashok Journal of Organic Chemistry, 1999 , vol. 64, # 13 p. 4665 - 4668
Article illustration

1,3-Dioxolane

646-06-0

Article illustration

Guanine

73-40-5

Article illustration

Carbon

7440-44-0

~78%

Article illustration

Acyclovir

59277-89-3

Literature: Syntex (U.S.A.) Inc. Patent: US5567816 A1, 1996 ;
Article illustration

9-[(2-acetoxyet...

112233-78-0

~91%

Article illustration

Acyclovir

59277-89-3

Literature: Robins, Morris J.; Zou, Ruiming; Guo, Zhiqiang; Wnuk, Stanislaw F. Journal of Organic Chemistry, 1996 , vol. 61, # 26 p. 9207 - 9212

 Precursor & DownStream

Precursor  6

Previous 1/2 Next

  • Article illustration CAS#:75128-73-3
    9-[(2-Acetoxyet...

  • Article illustration CAS#:646-06-0
    1,3-Dioxolane

  • Article illustration CAS#:73-40-5
    Guanine

  • Article illustration CAS#:7440-44-0
    Carbon

DownStream  10

Previous 1/3 Next

  • Article illustration CAS#:502421-44-5
    L-VALINE,N-[(1,...

  • Article illustration CAS#:73-40-5
    Guanine

  • Article illustration CAS#:102728-64-3
    9-(2'-ACETOXYET...

  • Article illustration CAS#:75128-73-3
    9-[(2-Acetoxyet...

 Customs

HS Code2933990090
Summary2933990090. heterocyclic compounds with nitrogen hetero-atom(s) only. VAT:17.0%. Tax rebate rate:13.0%. . MFN tariff:6.5%. General tariff:20.0%

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 Synonyms

Zovir
9-((2-Hydroxyethoxy)methyl)guanine
EINECS 261-685-1
Poviral
aclovir
bw248u
Acyclo-V
Maynar
9-(2-Hydroxyethoxy)methylguanine
Vimrax
Zoviax
Aciclovir
Zyclir
Cycloviran
2-Amino-9-((2-hydroxyethoxy)methyl)-1H-purin-6(9H)-one
Viroraxl
Azone
w-248-u
BW 248U
2-Amino-9-[(2-hydroxyethoxy)methyl]-1,9-dihydro-6H-purin-6-one
2-amino-9-{[(2-hydroxyethyl)oxy]methyl}-1,9-dihydro-6H-purin-6-one
6H-Purin-6-one, 2-amino-1,9-dihydro-9-[(2-hydroxyethoxy)methyl]-
9-[(2-Hydroxyethoxy)methyl]guanine
Wellcome 248U
Cargosil
Zovirax
Acyclovir
9-(2-Hydroxyethyloxymethyl)guanine
6H-Purin-6-one, 2-amino-1,9-dihydro-9-((2-hydroxyethoxy)methyl)-
ACV
MFCD00057880
Acycloguanosine
vipral
Herpevir
Gerpevir
virorax
Top Suppliers:I want be here

  • GL Biochem (Shanghai) Ltd.

  • China

  • Product Name: ACV

  • Price:$Inquiry/1g

  • Purity: 98.0%

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  • Shanghai Jizhi Biochemical Technology Co., Ltd

  • China

  • Product Name: Acyclovir

  • Price:￥358.0/25g￥128.0/5g

  • Purity: 98.0%

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  • Contact: Liu jia Article illustration Article illustration

  • DC Chemicals Limited

  • China

  • Product Name: Acyclovir (Aciclovir)

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  • Henan Tianfu Chemical Co., Ltd.

  • China

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  • Purity: 99.0%

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Get all suppliers and price by the below link:

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Price: ￥273/10mg

Reference only. check more Acyclovir price

Related Compounds:More...
Acyclovir
59877-89-3
Acyclovir-d4
1185179-33-2
acyclovir hydrate
93845-62-6
Acyclovir Acetate
102728-64-3
acyclovir butyrate
64843-83-0
acyclovir pivarate
64844-18-4
Acyclovir alaninate
84499-64-9
acyclovir phosphite
157722-20-8
N2-Acetyl Acyclovir
110104-37-5


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Henan Fengda Chemical Co., Ltd. is located in the High-tech Development Zone of Henan Province. Specializing in the production and sales of various fine chemical products required for industrial production, including chemical raw materials, organic raw materials, petrochemicals, chemical reagents, solvents, catalysts, and additives, etc.

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