N-(5-bromo-2-methoxybenzyl)tricyclo[3.3.1.1~3,7~]decan-1-amine
| 中文名稱 | N-(5-bromo-2-methoxybenzyl)tricyclo[3.3.1.1~3,7~]decan-1-amine |
|---|---|
| 中文同義詞 | 化合物 T10222;化合物ABMA;N-(5-溴-2-甲氧基芐基)金剛烷-1-胺 |
| 英文名稱 | N-(5-bromo-2-methoxybenzyl)tricyclo[3.3.1.1~3,7~]decan-1-amine |
| 英文同義詞 | N-(5-bromo-2-methoxybenzyl)tricyclo[3.3.1.1~3,7~]decan-1-amine;ABMA;Tricyclo[3.3.1.13,7]decan-1-amine, N-[(5-bromo-2-methoxyphenyl)methyl]-;N-(5-Bromo-2-methoxybenzyl)adamantan-1-amine |
| CAS號 | 332108-65-3 |
| 分子式 | C18H24BrNO |
| 分子量 | 350.29 |
| EINECS號 | |
| 相關(guān)類別 | |
| Mol文件 | 332108-65-3.mol |
| 結(jié)構(gòu)式 | ![N-(5-bromo-2-methoxybenzyl)tricyclo[3.3.1.1~3,7~]decan-1-amine 結(jié)構(gòu)式](CAS/20180601/GIF/332108-65-3.gif) |
N-(5-bromo-2-methoxybenzyl)tricyclo[3.3.1.1~3,7~]decan-1-amine 性質(zhì)
| 沸點(diǎn) | 428.2±30.0 °C(Predicted) |
|---|---|
| 密度 | 1.35±0.1 g/cm3(Predicted) |
| 儲存條件 | Store at -20°C |
| 溶解度 | 二甲基亞砜：125 mg/mL（356.85 mM） |
| 酸度系數(shù)(pKa) | 9.86±0.20(Predicted) |
| 形態(tài) | 固體 |
| 顏色 | 白色至米白色 |
Intracellular bacteria
Viruses
Parasite
ABMA protects cells against four bacterial toxins (
Corynebacterium diphtheriae
(DT; EC
50
of 62.9 μM),
Bacillus anthracis
(LT),
Clostridium difficile
toxin B (TcdB; EC
50
of 73.3?μM),
Clostridium sordellii
lethal toxin (TcsL; EC
50
of 86.7 μM)), three viruses (Ebola (EC
50
of 3.3?μM), rabies (EC
50
of 19.4?μM), dengue-4 virus ( EC
50
of 8.2?μM)), two species of Chlamydiales intracellular bacteria (
Simkania negevensis
and
Chlamydia trachomatis
), and the parasite
Leishmania infantum
(EC
50
of 7.1?μM) at micromolar level.
In A549 cells, ABMA treatment induces a decrease in ricin cytotoxicity with an EC
50
of 3.8?μM, and a protection factor (R) at 30?μM ranging from 5 to 10. ABMA retained almost 100% of its biological activity against ricin-induced cytotoxicity up to six days.
ABMA (2-200 mg/kg; intraperitoneal injection; female BALB/c mice) treatment protects mice from nasal instillation of an LD 90 of ricin.
| Animal Model: | Pathogen-free female BALB/c mice (6 week-old) with ricin |
| Dosage: | 2 mg/kg, 20 mg/kg, 200 mg/kg |
| Administration: | Intraperitoneal injection |
| Result: | A statistically significant protection according to survival curves was observed with a single ip dose of 2?mg/kg. The 20?mg/kg dose fully protected animals through to day 21. The 200?mg/kg dose resulted in 80% of protection of mice against ricin challenge with a single animal succumbing on day 15. |
安全信息
| 更新日期 | 產(chǎn)品編號 | 產(chǎn)品名稱 | CAS號 | 包裝 | 價格 |
|---|---|---|---|---|---|
| 2024/11/08 | HY-124801 | ABMA | 5 mg | 937元 | |
| 2024/11/08 | HY-124801 | N-(5-bromo-2-methoxybenzyl)tricyclo[3.3.1.1~3,7~]decan-1-amine ABMA | 332108-65-3 | 10mg | 1500元 |