ethyl 4-((4-(diethylamino)phenyl)imino)-6-methyl-1,4-dihydroquinoline-3-carboxylate manufacturers
- MCU-i4
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- $37.00 / 5mg
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2024-11-19
- CAS:371924-24-2
- Min. Order:
- Purity: 99.79%
- Supply Ability: 10g
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| | ethyl 4-((4-(diethylamino)phenyl)imino)-6-methyl-1,4-dihydroquinoline-3-carboxylate Basic information |
| Product Name: | ethyl 4-((4-(diethylamino)phenyl)imino)-6-methyl-1,4-dihydroquinoline-3-carboxylate | | Synonyms: | ethyl 4-((4-(diethylamino)phenyl)imino)-6-methyl-1,4-dihydroquinoline-3-carboxylate;Ethyl 4-((4-(diethylamino)phenyl)amino)-6-methylquinoline-3-carboxylate;C2C12,Inhibitor,mitochondrial,MCU-i-4,Mitochondrial Metabolism,MCU-i4,MCUi4,Ca2+,uptake,inhibit,MCU i4,myoblast;3-Quinolinecarboxylic acid, 4-[[4-(diethylamino)phenyl]amino]-6-methyl-, ethyl ester | | CAS: | 371924-24-2 | | MF: | C23H27N3O2 | | MW: | 377.48 | | EINECS: | | | Product Categories: | | | Mol File: | 371924-24-2.mol |  |
| | ethyl 4-((4-(diethylamino)phenyl)imino)-6-methyl-1,4-dihydroquinoline-3-carboxylate Chemical Properties |
| Boiling point | 513.1±50.0 °C(Predicted) | | density | 1.163±0.06 g/cm3(Predicted) | | storage temp. | 4°C, protect from light | | solubility | DMSO:18.87(Max Conc. mg/mL);50.0(Max Conc. mM)
Ethanol:37.75(Max Conc. mg/mL);100.0(Max Conc. mM) | | form | Solid | | pka | 7.21±0.44(Predicted) | | color | White to yellow |
| | ethyl 4-((4-(diethylamino)phenyl)imino)-6-methyl-1,4-dihydroquinoline-3-carboxylate Usage And Synthesis |
| Biological Activity | MCU-i4 blocks the IP3-dependent mitochondrial Ca2+-uptake, maintaining the gatekeeping role of their target[1][2].
MCU-i4 modulates mitochondrial Ca2+ uptake to 1 min of incubation, i.e., exerting a negative modulation, indicating that the primary effect of these compounds is a sudden and direct modulation of MCU complex activity[1].MCU-i4 exerted a negative effect on δψ. MCU-i4 has no effect on cell viability[1]. Cell Differentiation Assay[1] Cell Line: Growing medium of 90% confluent C2C12 myoblasts. | | storage | Store at -20°C | | References | [1]. Giulia Di Marco, et al. A High-Throughput Screening Identifies MICU1 Targeting Compounds. Cell Rep. 2020 Feb 18;30(7):2321-2331.e6.
[2]. Alessandro Rimessi, et al. Update on Calcium Signaling in Cystic Fibrosis Lung Disease. Front Pharmacol. 2021 Mar 11;12:581645. |
| | ethyl 4-((4-(diethylamino)phenyl)imino)-6-methyl-1,4-dihydroquinoline-3-carboxylate Preparation Products And Raw materials |
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